CAS No.: 1370261-96-3
PRT062607 Catalog No. CSN15717
Synonyms: P505-15;PRT-2607;BIIB-057
PRT062607 is a highly specific and potent inhibitor of Syk with IC50 of 1-2 nM with > 80-fold selectivity for Syk than Fgr, Lyn, FAK, Pyk2 and Zap70.
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纯度 & 质量文件
批次:
靶点选择性
生物活性
靶点 Syk
IC50:1-2nM- 描述
- 参考文献
- [1] Spurgeon SE, Coffey G, et al. The selective SYK inhibitor P505-15 (PRT062607) inhibits B cell signaling and function in vitro and in vivo and augments the activity of fludarabine in chronic lymphocytic leukemia. J Pharmacol Exp Ther. 2013 Feb;344(2):378-87.
- [2] Coffey G, DeGuzman F, et al. Specific inhibition of spleen tyrosine kinase suppresses leukocyte immune function and inflammation in animal models of rheumatoid arthritis. J Pharmacol Exp Ther. 2012 Feb;340(2):350-9.
实验方案
- 计算器
- 储存液制备
技术信息
| CAS号 | 1370261-96-3 | 储存条件 |
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| 分子式 | C19H23N9O | 运输 | 蓝冰 | |
| 分子量 | 393.45 | 别名 | P505-15;PRT-2607;BIIB-057 |
