|伪原薯蓣皂苷|CsnPharm

CAS No.: 102115-79-7

Pseudoprotodioscin/伪原薯蓣皂苷 Catalog No. CSN14080

Synonyms: OP31761;伪原薯蓣皂苷

Pseudoprotodioscin shows a weaker suppressing effect on the production of inflammatory cytokines and can suppress melanogenesis in B16F1 cells. It's a natural product isolated and purified from the rhizomes of Dioscorea nipponica Makino. with moderate cytotoxicity.Pseudoprotodioscin inhibits SREBP1/2 and microRNA 33a/b levels and reduces the gene expression regarding the synthesis of cholesterol and triglycerides.

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技术信息

生物活性

描述Pseudoprotodioscin (PPD), a phytoestrogen isolated from Dioscorea nipponica Makino, is recognized to possess anti-inflammatory and antiadipogenic capacities. PPD administration alleviated atherosclerotic lesions by lowering total cholesterol in ovariectomized apoE-/- mice fed a high-cholesterol diet. In Hep G2 cells, Pseudoprotodioscin increases ABCA1 protein and mRNA levels, and promotes the effluxion of ApoA-1-mediated cholesterol. Pseudoprotodioscin inhibits SREBP1c and SREBP2 transcription by decreasing microRNA 33a/b levels^[3]. Pseudoprotodioscin, a furostanoside, inhibits SREBP1/2 and microRNA 33a/b levels and reduces the gene expression regarding the synthesis of cholesterol and triglycerides. Upon PPD treatment, ERα and endothelial nitric oxide synthase (eNOS) protein levels were increased, whereas cell adhesion molecule and monocyte chemoattractant protein-1 (MCP-1) mRNA levels were suppressed in human umbilical vein endothelial cells (HUVECs) after injury caused by oxidized low-density lipoprotein (ox-LDL)^[4].
参考文献

[1] Liao M, Chen X, et al. Determination of pseudoprotodioscin in rat plasma by UPLC-MS/MS: Assay development and application to pharmacokinetic study. J Chromatogr B Analyt Technol Biomed Life Sci. 2016 Jul 15;1026:97-104.
[2] Kawabata T, Cui MY, et al. Anti-inflammatory and anti-melanogenic steroidal saponin glycosides from Fenugreek (Trigonella foenum-graecum L.) seeds. Planta Med. 2011 May;77(7):705-10.
[3] Sun B, Yang D, Yin YZ, Xiao J. Estrogenic and anti-inflammatory effects of pseudoprotodioscin in atherosclerosis-prone mice: Insights into endothelial cells and perivascular adipose tissues. Eur J Pharmacol. 2020 Feb 15;869:172887
[4] Gai Y, Li Y, Xu Z, Chen J. Pseudoprotodioscin inhibits SREBPs and microRNA 33a/b levels and reduces the gene expression regarding the synthesis of cholesterol and triglycerides. Fitoterapia. 2019 Nov;139:104393

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 0.9698 mL
- 4.8488 mL
- 9.6976 mL
- 5 mM
- 0.1940 mL
- 0.9698 mL
- 1.9395 mL
- 10 mM
- 0.0970 mL
- 0.4849 mL
- 0.9698 mL

技术信息

CAS号

102115-79-7

储存条件

粉末: Sealed in dry,Room Temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C51H82O21

运输

蓝冰

分子量

1031.18

别名

OP31761;伪原薯蓣皂苷

溶解度

DMSO	100.0 mg/mL (97.0 mM)

动物实验配方

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Pseudoprotodioscin/伪原薯蓣皂苷 Catalog No. CSN14080

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