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CAS No.: 18642-23-4

psoralidin/补骨脂定 Catalog No. CSN16251

Synonyms: 补骨脂定

Psoralidin, a natural furanocoumarin, is isolated from Psoralea corylifolia L. with anticancer and chemopreventive properties, inhibits Akt phosphorylation and phosphatidylinositol 3-kinase activation.

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400-920-2911

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生物活性

描述Psoralidin is a dual inhibitor of COX-2 and 5-LOX, regulates ionizing radiation (IR)-induced pulmonary inflammation, with anti-cancer, anti-bacterial, and anti-inflammatory properties^[3]. Three breast cancer cell populations (ALDH- cells, ALDH+ cells, and commercial BSCSs) are sensitive to Psoralidin treatment (10, 15, 20, and 25 μM; 24 hours) with IC50s ranging from 18 to 21 μM; however, the MCF-12A cells were resistant to Psoralidin. Psoralidin (30 μM; 24 hours) results in a significant induction of apoptosis for ALDH- cells, ALDH+ cells, and commercial BCSCs^[4]. Psoralidin decreased the viability of the liver cancer HepG2 cells and exhibited an IC50 of 9 µM. Also, Psoralidin exerted very low toxic effects on the normal AML12 hepatocytes exhibiting an IC50 of 100 µM^[5]. Psoralidin treatment could reverse the caffeine-induced dysfunctions and aberrant differentiation of BMSCs (bone marrow mesenchymal stem cells) via the ER pathway^[6].
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.9732 mL
- 14.8660 mL
- 29.7320 mL
- 5 mM
- 0.5946 mL
- 2.9732 mL
- 5.9464 mL
- 10 mM
- 0.2973 mL
- 1.4866 mL
- 2.9732 mL

技术信息

CAS号

18642-23-4

储存条件

粉末: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C20H16O5

运输

蓝冰

分子量

336.34

别名

补骨脂定

溶解度

DMSO	66.0 mg/mL (196.2 mM)
Water	Insoluble
Ethanol	1.0 mg/mL (3.0 mM)

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