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CAS No.: 483367-10-8
Synonyms: Shh Signaling Antagonist VI
Purmorphamine is an activator of Smoothened, and blocks BODIPY-cyclopamine binding to Smo with IC50 of appr 1.5 μM and also is an inducer of osteoblast differentiation with EC50 of 1 μM.
生物活性
靶点 | Smo IC50:~1.5μM |
动物研究 | |
剂量 | Rat: 0.5 mg/kg - 5 mg/kg[3] (i.p.) |
给药途径 | i.p. |
实验方案
技术信息
CAS号 | 483367-10-8 | 储存条件 |
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分子式 | C31H32N6O2 | 运输 | 蓝冰 | |||||||||||||
分子量 | 520.62 | 别名 | Shh Signaling Antagonist VI | |||||||||||||
溶解度 |
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动物实验配方 |
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Cell Lines | Concentration | Assay Type | Time | Activity Description | Data Sources |
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HEK293T cells | 5 μM | Function assay | 4 h | Inhibition of BODIPY-cyclopamine binding to Smo C-terminal cytoplasmic domain expressed in HEK293T cells at 5 uM after 4 hrs by fluorescence microscopy | 16408088 |
mouse C3H10T1/2 cells | - | Function assay | - | Induction of osteogenesis in mouse C3H10T1/2 cells assessed as induction of osteoblast specific marker alkaline phosphatase by immunofluorescence method, EC50=1 μM | 16408003 |
mouse Shh Light2 cells | - | Function assay | 30 h | Activation of Shh in mouse Shh Light2 cells after 30 hrs by luciferase reporter gene assay, EC50=1 μM | 16408088 |
靶点 | Description | IC50 |
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Smo | IC50:~1.5μM |
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