CAS No.: 545380-34-5
QNZ Catalog No. CSN12289
Synonyms: EVP4593;CAY-10470
QNZ can inhibit the activation of NF-κB and the production of TNF-α with IC50 of 11 nM and 7 nM, respectively.
| 规格 | 价格 | 促销价格 | 库存 | 数量 |
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纯度 & 质量文件
批次:
靶点选择性
生物活性
- 描述
- 作用机制
- 细胞研究
- Cell Data
- 更多
动物研究 剂量 Mice: 1 mg/kg[7] (i.p.)
给药途径 i.p.
- 参考文献
- [1] Tobe M, Isobe Y, et al. Discovery of quinazolines as a novel structural class of potent inhibitors of NF-kappa B activation. Bioorg Med Chem. 2003;11(3):383-91.
- [2] Tobe M, Isobe Y, et al. A novel structural class of potent inhibitors of NF-kappa B activation: structure-activity relationships and biological effects of 6-aminoquinazoline derivatives. Bioorg Med Chem. 2003;11(18):3869-78.
- [3] Tsai JJ, Pan PJ, et al. Regorafenib induces extrinsic and intrinsic apoptosis through inhibition of ERK/NF-κB activation in hepatocellular carcinoma cells. Oncol Rep. 2017;37(2):1036-1044.
- [4] Macedo SR, de Figueiredo Nicolete LD, et al. The pentavalent antimonial therapy against experimental Leishmania amazonensis infection is more effective under the inhibition of the NF-κB pathway. Int Immunopharmacol. 2015;28(1):554-9.
- [5] Zhu X, Huang L, et al. NF-κB pathway link with ER stress-induced autophagy and apoptosis in cervical tumor cells. Cell Death Discov. 2017.
- [6] Gupta SC, Sundaram C, et al. Inhibiting NF-κB activation by small molecules as a therapeutic strategy. Biochim Biophys Acta. 2010;1799(10-12):775-87.
实验方案
- 计算器
- 储存液制备
技术信息
| CAS号 | 545380-34-5 | 储存条件 |
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| 分子式 | C22H20N4O | 运输 | 蓝冰 | |||||
| 分子量 | 356.42 | 别名 | EVP4593;CAY-10470 | |||||
| 溶解度 |
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动物实验配方 |
