|γ-谷维素|CsnPharm

CAS No.: 11042-64-1

γ-Oryzanol/γ-谷维素 Catalog No. CSN20797

Synonyms: Gamma-oryzanol;γ-谷维素

γ-Oryzanol is a phytochemical with membrane antioxidant, naturally occurring in crude rice bran oil, can be used to treat hyperlipidemia, disorders of menopause and to increase the muscle mass.

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生物活性

实验方案

技术信息

生物活性

描述γ-Oryzanol is a potent DNA methyltransferases (DNMTs) inhibitor in the striatum of mice. γ-Oryzanol significantly inhibits the activities of DNMT1 (IC50=3.2 μM), DNMT3a (IC50=22.3 μM). γ-oryzanol ameliorates HFD (high-fat diet)-induced DNA hypermethylation of the promoter region of D2R in the striatum of mice^[1]. In pancreatic islets from both high-fat diet-induced and streptozotocin-induced diabetic mice, γ-oryzanol ameliorates endoplasmic reticulum stress and protects β-cells against apoptosis. γ-oryzanol also acts as a potent inhibitor against deoxyribonucleic acid methyltransferases in the brain reward system (striatum) in mice, thereby attenuating, at least partly, the preference for a high-fat diet through the epigenetic modulation of striatal dopamine D2 receptor^[2]. γ-oryzanol modulates quantitative changes of proteins involved in synaptic plasticity and neuronal trafficking, neuroprotection and antioxidant activity, and mitochondria and energy metabolism^[3]. Chronic consumption of γ-oryzanol can revert the LPS-induced cognitive and memory impairments by promoting hippocampal antioxidant and anti-inflammatory molecular responses^[4].
参考文献

[1] Kozuka C, Kaname T, Shimizu-Okabe C, Takayama C, Tsutsui M, Matsushita M, Abe K, Masuzaki H. Impact of brown rice-specific γ-oryzanol on epigenetic modulation of dopamine D2 receptors in brain striatum in high-fat-diet-induced obesity in mice. Diabetologia. 2017 Aug;60(8):1502-1511
[2] Masuzaki H, Kozuka C, Okamoto S, Yonamine M, Tanaka H, Shimabukuro M. Brown rice-specific γ-oryzanol as a promising prophylactic avenue to protect against diabetes mellitus and obesity in humans. J Diabetes Investig. 2019 Jan;10(1):18-25
[3] Rungratanawanich W, Cenini G, Mastinu A, Sylvester M, Wilkening A, Abate G, Bonini SA, Aria F, Marziano M, Maccarinelli G, Memo M, Voos W, Uberti D. γ-Oryzanol Improves Cognitive Function and Modulates Hippocampal Proteome in Mice. Nutrients. 2019 Mar 31;11(4):753
[4] Mastinu A, Bonini SA, Rungratanawanich W, Aria F, Marziano M, Maccarinelli G, Abate G, Premoli M, Memo M, Uberti D. Gamma-oryzanol Prevents LPS-induced Brain Inflammation and Cognitive Impairment in Adult Mice. Nutrients. 2019 Mar 29;11(4):728

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 1.6587 mL
- 8.2934 mL
- 16.5868 mL
- 5 mM
- 0.3317 mL
- 1.6587 mL
- 3.3174 mL
- 10 mM
- 0.1659 mL
- 0.8293 mL
- 1.6587 mL

技术信息

CAS号

11042-64-1

储存条件

粉末: Sealed in dry,Room Temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C40H58O4

运输

蓝冰

分子量

602.89

别名

Gamma-oryzanol;γ-谷维素

溶解度

DMSO	100.0 mg/mL (165.9 mM)

动物实验配方

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γ-Oryzanol/γ-谷维素 Catalog No. CSN20797

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