CAS No.: 195055-03-9
R121919 Catalog No. CSN11823
Synonyms: NBI30775;R-121,919
R121919 is a potent small-molecule CRF1 receptor antagonist with a Ki of 2 to 5 nM for the CRF1 receptor and over 1000-fold weaker activity at the CRF2 receptor, CRF-binding protein, or 70 other receptor types.
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纯度 & 质量文件
批次:
靶点选择性
生物活性
- 描述
- 参考文献
- [1] Gutman DA, Coyer MJ, et al. Behavioral effects of the CRF1 receptor antagonist R121919 in rats selectively bred for high and low activity in the swim test. Psychoneuroendocrinology. 2008 Sep;33(8):1093-101.
- [2] Gutman DA, Owens MJ, et al. The corticotropin-releasing factor1 receptor antagonist R121919 attenuates the behavioral and endocrine responses to stress. J Pharmacol Exp Ther. 2003 Feb;304(2):874-80.
实验方案
- 计算器
- 储存液制备
技术信息
| CAS号 | 195055-03-9 | 储存条件 |
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| 分子式 | C22H32N6 | 运输 | 蓝冰 | |
| 分子量 | 380.53 | 别名 | NBI30775;R-121,919 |
