CAS No.: 1617495-03-0
RA190 Catalog No. CSN26934
RA190 is a potent Rpn13 inhibitor and ADRM1 Inhibitor, Suppressing Intrahepatic Cholangiocarcinoma by Inducing NF-kappaB-Mediated Cell Apoptosis. RA190 represents a novel class of proteasome inhibitor that covalently binds to cysteine 88 of RPN13, an ubiquitin receptor subunit of the proteasome's 19S regulatory particle. RA190 treatment inhibits proteasome function, causing rapid accumulation of polyubiquitinated proteins. RA190 has therapeutic activity in a xenograft model, and with sorafenib exhibited synergetic killing of HCC cells in vitro, suggesting further exploration of such a combination treatment of HCC is warranted.
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纯度 & 质量文件
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技术信息
| CAS号 | 1617495-03-0 | 储存条件 |
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| 分子式 | C28H23Cl5N2O2 | 运输 | 蓝冰 | |||||||
| 分子量 | 596.76 | 别名 | ||||||||
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动物实验配方 |
