CAS No.: 1093100-40-3
Raf inhibitor 1 Catalog No. CSN16200
Synonyms: B-Raf Inhibitor 1;MDK-0403
B-Raf inhibitor 1 is an inhibitor of B-Raf with IC50s ranging from 0.31 μM to 2 nM in cells assay.
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纯度 & 质量文件
批次:
靶点选择性
生物活性
- 描述
- 临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点 NCT01682083 Melanoma Phase 3 Active, not recruiting November 30, 2030 - NCT02837263 Colorectal Cancer ... more >> Colorectal Adenocarcinoma Stage IVA Colorectal Cancer Stage IVB Colorectal Cancer Metastatic Carcinoma in the Liver Collapse << Phase 1 Recruiting June 2021 United States, Wisconsin ... more >> University of Wisconsin Carbone Cancer Center Recruiting Madison, Wisconsin, United States, 53792 Contact: Cancer Connect 800-622-8922 cancerconnect@uwcarbone.wisc.edu Principal Investigator: Dustin Deming Collapse << NCT02308553 Cutaneous Malignant Melanoma Phase 1 Phase 2 Recruiting June 2018 Germany ... more >> University Hospital Essen Recruiting Essen, NRW, Germany, 45147 Contact: Dirk Schadendorf, Prof. Dr. +49-201- 723 ext 4342 dirk.schadendorf@uk-essen.de Principal Investigator: Dirk Schadendorf, Prof. Dr. Elbeklinikum Buxtehude Recruiting Buxtehude, Germany, 21614 Contact: Peter Mohr, Dr. med. peter.mohr@elbekliniken.de Principal Investigator: Peter Mohr, Dr. med. SRH Wald-Klinikum Gera Not yet recruiting Gera, Germany, 07548 Contact: Martin Kaatz, PD Dr. martin.kaatz@wkg.srh.de Principal Investigator: Martin Kaatz, PD Dr. National Centre for Tumour Diseases (NCT) Recruiting Heidelberg, Germany, 69120 Contact: Jessica Hassel, Dr. med. jessica.hassel@med.uni-heidelberg.de Principal Investigator: Jessica Hassel, Dr. med. Universitätsklinikum des Saarlandes Not yet recruiting Homburg, Germany, 66421 Contact: Claudia Pföhler, PD Dr. claudia.pfoehler@uks.eu Principal Investigator: Claudia Pföhler, PD Dr. Klinikum der Stadt Ludwigshafen am Rhein gGmbH Recruiting Ludwigshafen, Germany, 67063 Contact: Edgar Dippel, Prof. Dr. dippele@klilu.de Principal Investigator: Edgar Dippel, Prof. Dr. Universitätsklinikum Schleswig-Holstein, Campus Lübeck Not yet recruiting Lübeck, Germany, 23538 Contact: Patrick Terheyden, PD Dr. patrick.terheyden@uksh.de Principal Investigator: Patrick Terheyden, PD Dr. University Hospital München Recruiting München, Germany, 80337 Contact: Carola Berking, Prof. Dr. carola.berking@med.uni-muenchen.de Principal Investigator: Carola Berking, Prof. Dr. Fachklinik Hornheide Recruiting Münster, Germany, 48157 Contact: Michael Fluck, Dr. med. michael.fluck@fachklinik-hornheide.de Principal Investigator: Michael Fluck, Dr. med. Collapse << - 更多
实验方案
- 计算器
- 储存液制备
技术信息
| CAS号 | 1093100-40-3 | 储存条件 |
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| 分子式 | C26H19ClN8 | 运输 | 蓝冰 | |||||
| 分子量 | 478.94 | 别名 | B-Raf Inhibitor 1;MDK-0403 | |||||
| 溶解度 |
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动物实验配方 |
| NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
|---|
| NCT01682083 | Melanoma | Phase 3 | Active, not recruiting | November 30, 2030 | - |
| NCT02837263 | Colorectal Cancer ... more >> Colorectal Adenocarcinoma Stage IVA Colorectal Cancer Stage IVB Colorectal Cancer Metastatic Carcinoma in the Liver Collapse << | Phase 1 | Recruiting | June 2021 | United States, Wisconsin ... more >> University of Wisconsin Carbone Cancer Center Recruiting Madison, Wisconsin, United States, 53792 Contact: Cancer Connect 800-622-8922 cancerconnect@uwcarbone.wisc.edu Principal Investigator: Dustin Deming Collapse << |
| NCT02308553 | Cutaneous Malignant Melanoma | Phase 1 Phase 2 | Recruiting | June 2018 | Germany ... more >> University Hospital Essen Recruiting Essen, NRW, Germany, 45147 Contact: Dirk Schadendorf, Prof. Dr. +49-201- 723 ext 4342 dirk.schadendorf@uk-essen.de Principal Investigator: Dirk Schadendorf, Prof. Dr. Elbeklinikum Buxtehude Recruiting Buxtehude, Germany, 21614 Contact: Peter Mohr, Dr. med. peter.mohr@elbekliniken.de Principal Investigator: Peter Mohr, Dr. med. SRH Wald-Klinikum Gera Not yet recruiting Gera, Germany, 07548 Contact: Martin Kaatz, PD Dr. martin.kaatz@wkg.srh.de Principal Investigator: Martin Kaatz, PD Dr. National Centre for Tumour Diseases (NCT) Recruiting Heidelberg, Germany, 69120 Contact: Jessica Hassel, Dr. med. jessica.hassel@med.uni-heidelberg.de Principal Investigator: Jessica Hassel, Dr. med. Universitätsklinikum des Saarlandes Not yet recruiting Homburg, Germany, 66421 Contact: Claudia Pföhler, PD Dr. claudia.pfoehler@uks.eu Principal Investigator: Claudia Pföhler, PD Dr. Klinikum der Stadt Ludwigshafen am Rhein gGmbH Recruiting Ludwigshafen, Germany, 67063 Contact: Edgar Dippel, Prof. Dr. dippele@klilu.de Principal Investigator: Edgar Dippel, Prof. Dr. Universitätsklinikum Schleswig-Holstein, Campus Lübeck Not yet recruiting Lübeck, Germany, 23538 Contact: Patrick Terheyden, PD Dr. patrick.terheyden@uksh.de Principal Investigator: Patrick Terheyden, PD Dr. University Hospital München Recruiting München, Germany, 80337 Contact: Carola Berking, Prof. Dr. carola.berking@med.uni-muenchen.de Principal Investigator: Carola Berking, Prof. Dr. Fachklinik Hornheide Recruiting Münster, Germany, 48157 Contact: Michael Fluck, Dr. med. michael.fluck@fachklinik-hornheide.de Principal Investigator: Michael Fluck, Dr. med. Collapse << |
| NCT01682083 | - | - | Active, not recruiting | - | - |
| NCT02313012 | Neoplasm Metastasis | Phase 1 | Terminated(The MTD did not off... more >>er a sufficiently encouraging profile to proceed with the additional dosing schedule or to the cohort expansion phase.) Collapse << | - | United States, California ... more >> Cedars Sinai Medical Center, Inflammatory Bowel Disease Center Los Angeles, California, United States, 90048 United States, Connecticut Smilow Cancer Center New Haven, Connecticut, United States, 06510 United States, North Carolina Levine Cancer Institute Charlotte, North Carolina, United States, 28204 United States, Tennessee Sarah Cannon Cancer Center Nashville, Tennessee, United States, 37203 Australia Peter MacCallum Cancer Centre East Melbourne, Australia, 3002 Collapse << |
| NCT01271803 | Malignant Melanoma | Phase 1 | Completed | - | United States, California ... more >> UCLA Department of Medicine Los Angeles, California, United States, 90024 University of California at San Francisco San Francisco, California, United States, 94115 The Angeles Clinic and Research Institute, Santa Monica Office Santa Monica, California, United States, 90025 United States, Colorado University of Colorado; Anschutz Cancer Pavilion Aurora, Colorado, United States, 80045 United States, Illinois University of Chicago Chicago, Illinois, United States, 60637 United States, Indiana Indiana University - Department of Medicine, Division of Gastroenterology/Hepatology Indianapolis, Indiana, United States, 46202 United States, Michigan Karmanos Cancer Inst. ; Hudson Webber; Cancer Research Building Detroit, Michigan, United States, 48201 United States, New York New York University Medical Center New York, New York, United States, 10036 United States, Tennessee Vanderbilt University Medical Center Nashville, Tennessee, United States, 37232 Australia, Victoria Peter Maccallum Cancer Institute; Medical Oncology Melbourne, Victoria, Australia, 3000 Collapse << |
| NCT01740648 | Recurrent Rectal Cancer ... more >> Stage IIA Rectal Cancer Stage IIB Rectal Cancer Stage IIC Rectal Cancer Stage IIIA Rectal Cancer Stage IIIB Rectal Cancer Stage IIIC Rectal Cancer Collapse << | Phase 1 | Active, not recruiting | December 31, 2022 | United States, Missouri ... more >> Washington University Saint Louis, Missouri, United States, 63110 United States, Ohio Arthur G. James Cancer Hospital and Solove Research Institute at Ohio State University Medical Center Columbus, Ohio, United States, 43210 United States, Tennessee Vanderbilt University Nashville, Tennessee, United States Collapse << |
| NCT01138085 | Cancer | Phase 1 | Completed | - | United States, Colorado ... more >> GSK Investigational Site Aurora, Colorado, United States, 80045 United States, Connecticut GSK Investigational Site New Haven, Connecticut, United States, 06520 United States, Massachusetts GSK Investigational Site Boston, Massachusetts, United States, 02114 GSK Investigational Site Boston, Massachusetts, United States, 02215 United States, New Jersey GSK Investigational Site New Brunswick, New Jersey, United States, 08901 United States, Tennessee GSK Investigational Site Nashville, Tennessee, United States, 37232 United States, Texas GSK Investigational Site Dallas, Texas, United States, 75246 GSK Investigational Site Houston, Texas, United States, 77230-1439 GSK Investigational Site San Antonio, Texas, United States, 78229 United States, Utah GSK Investigational Site Salt Lake City, Utah, United States, 84112-5550 Collapse << |
| NCT02857270 | Advanced Cancer ... more >> Metastatic Melanoma Metastatic Non-small Cell Lung Cancer Metastatic Pancreatic Ductal Adenocarcinoma Colorectal Cancer Collapse << | Phase 1 | Recruiting | July 13, 2020 | United States, District of Col... more >>umbia Georgetown University Medical Center Not yet recruiting Washington, District of Columbia, United States, 20007 Contact 202-444-2223 Principal Investigator: Stephen V Liu United States, Florida Florida Cancer Specialists Recruiting Sarasota, Florida, United States, 34232 Contact 9413779993 Principal Investigator: Manish Rajni Patel United States, Massachusetts Massachusetts General Hospital Recruiting Boston, Massachusetts, United States, 02114 Contact 617-643-3614 Principal Investigator: Ryan Sullivan United States, New Hampshire Dartmouth Hitchcock Medical Center Not yet recruiting Lebanon, New Hampshire, United States, 03756-0001 Contact 603-650-6344 Principal Investigator: Konstantin Dragnev United States, Pennsylvania UPMC Hillman Cancer Center Recruiting Pittsburgh, Pennsylvania, United States, 15232-1305 Contact 412-864-7859 Principal Investigator: Timothy F Burns United States, Tennessee Sarah Cannon Cancer Center Recruiting Nashville, Tennessee, United States, 37203 Contact 615-329-7274 Principal Investigator: SMO Sarah Cannon Research Inst. Tennessee Oncology PLLC Recruiting Nashville, Tennessee, United States, 37203 Contact 6153297274 Principal Investigator: Johanna Chock Bendell United States, Texas University of Texas MD Anderson Cancer Center Recruiting Houston, Texas, United States, 77030 Contact 713-745-6601 Principal Investigator: Shubham Pant Australia, New South Wales St Vincent's Hospital Recruiting Sydney, New South Wales, Australia, 2010 Contact 61293555655 Principal Investigator: Anthony Joshua Australia, Western Australia Linear Clinical Research Ltd Recruiting Nedlands, Western Australia, Australia, 6009 Contact 61861510923 Principal Investigator: Michael J Millward France Gustave Roussy Recruiting Villejuif Cedex, France, 94805 Contact 33142114385 Principal Investigator: Antoine Hollebecque Collapse << |
| NCT03042221 | - | - | Recruiting | April 30, 2019 | United States, Colorado ... more >> University of Colorado, Cancer Center Recruiting Aurora, Colorado, United States, 80045 Contact: Mary K Jackson 303-724-1650 mary.k.jackson@ucdenver.edu Contact: Terry NG, MD 303-724-2980 terry.ng@ucdenver.edu Principal Investigator: Terry ng, MD Collapse << |
| NCT01748149 | Pediatric Recurrent/Refractory... more >> BRAFV600E-mutant Gliomas Collapse << | Early Phase 1 | Active, not recruiting | June 2020 | - |
| NCT01820364 | - | - | Terminated(Study was withdrawn... more >> due to scientific and business considerations.) Collapse << | - | - |
| NCT02143999 | - | - | Completed | - | Italy ... more >> Policlinico Ospedaliero Ss Annunziata; U.O. Di Clinica Oncologica Chieti, Abruzzo, Italy, 66100 IRCCS IST. Tumori Fondaz. Pascale; S.C. Oncologia Medica,Melanoma,Immunoterapia E Terapie Innovative Napoli, Campania, Italy, 80131 Azienda Ospedaliero-Universitaria S.Orsola-Malpighi; Unità Operativa Oncologia Medica Bologna, Emilia-Romagna, Italy, 40138 Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST);U.O. di Immunoterapia Meldola, Emilia-Romagna, Italy, 47014 Arcispedale Santa Maria Nuova; Oncologia Reggio Emilia, Emilia-Romagna, Italy, 42100 Policlinico Universitario Campus Biomedico; Uoc Oncologia Medica Roma, Lazio, Italy, 00128 Policlinico Umberto i di Roma; dip. Scienze Radiologiche, Oncologiche, Anatomopatologiche Roma, Lazio, Italy, 00161 IRCCS Istituto Nazionale Per La Ricerca Sul Cancro (IST); Oncologia Medica A Genova, Liguria, Italy, 16132 Asst Papa Giovanni XXIII; Oncologia Medica Bergamo, Lombardia, Italy, 24128 Az. Osp. Spedali Civili; Divisione Di Oncologia - Iii Medicina Brescia, Lombardia, Italy, 25123 Irccs Istituto Nazionale Dei Tumori (Int);S.C. Medicina Oncologica 2 Milano, Lombardia, Italy, 20133 Irccs Istituto Europeo Di Oncologia (Ieo); Unita' Di Ricerca Traslazionale Del Melanoma Milano, Lombardia, Italy, 20141 Fondazione Del Piemonte Per L'oncologia IRCC Di Candiolo Candiolo, Piemonte, Italy, 10060 Azienda Sanitaria Ospedaliera s. Croce e Carle; Oncologia Medica Cuneo, Piemonte, Italy, 12100 Ospedale Maggiore Della Carita; Oncologia Medica Novara, Piemonte, Italy, 28100 Azienda Ospedaliera Città della Salute e della Scienza di Torino Torino, Piemonte, Italy, 10126 Istituto Tumori Giovanni Paolo II IRCCS Ospedale Oncologico Bari Bari, Puglia, Italy, 70124 Policlinico P. Giaccone; Istituto Di Oncologia, Clinica Medica 1 Palermo, Sicilia, Italy, 90127 Ospedale S. Vincenzo; Oncologia Medica Taormina, Sicilia, Italy, 98030 Azienda Sanitaria di Firenze Presidio Palagi - SC Dermatologia II e Fisioterapia Dermatologica Firenze, Toscana, Italy, 50125 Azlenda Ospendaliero-Universitaria Pisana; C.O. Oncologia 2 Pisa, Toscana, Italy, 56100 Azienda Ospedaliera Universitaria Senese, U.O.C. Immunoterapia Oncologica Siena, Toscana, Italy, 53100 Azienda Ospedaliero Universitaria di Ferrara - U.O. Di Oncologia Cona (FE), Veneto, Italy, 44124 Azienda Ospedaliera di Verona-Policlinico G.B. Rossi; Oncologia Medica Verona, Veneto, Italy, 37134 Collapse << |
| NCT02138292 | Melanoma | Phase 1 | Completed | - | United States, Texas ... more >> UT Southwestern Medical Center Dallas, Texas, United States, 75390 Collapse << |
| NCT01820364 | Melanoma | Phase 2 | Terminated(Study was withdrawn... more >> due to scientific and business considerations.) Collapse << | - | United States, Tennessee ... more >> Sarah Cannon Research Institute Onc Dept Nashville, Tennessee, United States, 37203 Australia, Victoria Novartis Investigative Site East Melbourne, Victoria, Australia, 3002 Canada, Alberta Novartis Investigative Site Edmonton, Alberta, Canada, T6G 1Z2 Germany Novartis Investigative Site Heidelberg, Germany, 69120 Spain Novartis Investigative Site Barcelona, Catalunya, Spain, 08035 Switzerland Novartis Investigative Site Zuerich, Switzerland, 8091 Collapse << |
| NCT02416232 | - | - | - | - | France ... more >> GSK Investigational Site Amiens Cedex, France, 80054 GSK Investigational Site Angers, France, 49100 GSK Investigational Site Bayonne cedex, France, 64109 GSK Investigational Site Besancon cedex, France, 25030 GSK Investigational Site Bobigny, France, 93000 GSK Investigational Site Bordeaux, France, 33075 GSK Investigational Site Boulogne-Billancourt, France, 92100 GSK Investigational Site Brest cedex, France, 29609 GSK Investigational Site Caen Cedex 9, France, 14033 GSK Investigational Site Chambray-Les-Tours, France, 37170 GSK Investigational Site Clermont-Ferrand cedex 1, France, 63003 GSK Investigational Site Creteil, France, 94010 GSK Investigational Site Dijon Cedex, France, 21079 GSK Investigational Site Grenoble cedex 9, France, 38043 GSK Investigational Site La Rochelle cedex 1, France, 17019 GSK Investigational Site Le Havre, France, 76083 GSK Investigational Site Le Mans, France, 72000 GSK Investigational Site Lille, France, 59037 GSK Investigational Site Limoges cedex, France, 87042 GSK Investigational Site Lorient, France, 56322 GSK Investigational Site Lyon Cedex 08, France, 69373 GSK Investigational Site Marseille Cedex 5, France, 13385 GSK Investigational Site Montpellier cedex 5, France, 34295 GSK Investigational Site Montpellier Cedex 5, France, 34298 GSK Investigational Site Mulhouse, France, 68100 GSK Investigational Site Nantes Cedex 1, France, 44093 GSK Investigational Site Nice, France, 06202 GSK Investigational Site Nimes, France, 30029 cedex 9 GSK Investigational Site Orleans Cedex 2, France, 45067 GSK Investigational Site Paris Cedex 10, France, 75475 GSK Investigational Site Paris, France, 75006 GSK Investigational Site Pau, France, 64000 GSK Investigational Site Pierre-Benite cedex, France, 69495 GSK Investigational Site Poitiers, France, 86021 GSK Investigational Site Pringy Cedex, France, 74374 GSK Investigational Site Reims Cedex, France, 51092 GSK Investigational Site Rennes Cedex, France, 35042 GSK Investigational Site Rouen, France, 76031 GSK Investigational Site Saint-Pierre, France, 97448 GSK Investigational Site Saint-Priest en Jarez, France, 42270 GSK Investigational Site Strasbourg Cedex, France, 67091 GSK Investigational Site Thionville, France, 57126 Cedex 1 GSK Investigational Site Toulouse Cedex 9, France, 31059 GSK Investigational Site Valence Cedex 9, France, 26953 GSK Investigational Site Vandoeuvre-Les-Nancy, France, 54511 GSK Investigational Site Villejuif cedex, France, 94805 Collapse << |
| NCT01245062 | Melanoma | Phase 3 | Completed | - | - |
| NCT03714958 | Colorectal Cancer ... more >> Advanced Cancer Metastatic Cancer Collapse << | Phase 1 | Not yet recruiting | November 2020 | - |
| NCT01271803 | - | - | Completed | - | - |
| NCT01245062 | - | - | Completed | - | - |
| NCT01605162 | Wild Type BRAF Stage IV Melano... more >>ma Unresectable Stage III Melanoma Collapse << | Phase 2 | Terminated | - | United States, Pennsylvania ... more >> Pittsburgh, Pennsylvania, United States Collapse << |
| NCT01941927 | Melanoma | Phase 2 | Unknown | May 2016 | United States, California ... more >> UCSF Helen Diller Family Comprehensive Cancer Center San Francisco, California, United States, 94115 United States, New York Memorial Sloan-Kettering Cancer Center New York City, New York, United States, 10065 Collapse << |
| NCT01721603 | BRAFV600E Melanoma Patients | Phase 2 | Terminated(Low accrual) | - | United States, California ... more >> University of San Francisco, California San Francisco, California, United States, 94115 Collapse << |
| NCT01721603 | - | - | Terminated(Low accrual) | - | - |
| NCT00888134 | Adult Solid Neoplasm | Phase 2 | Completed | - | United States, Massachusetts ... more >> Massachusetts General Hospital Cancer Center Boston, Massachusetts, United States, 02114 Dana-Farber Cancer Institute Boston, Massachusetts, United States, 02115 Beth Israel Deaconess Medical Center Boston, Massachusetts, United States, 02215 Massachusetts General Hospital Charlestown, Massachusetts, United States, 02129 United States, New York Memorial Sloan-Kettering Cancer Center New York, New York, United States, 10065 Collapse << |
| NCT02910700 | BRAF Gene Mutation ... more >> BRAF wt Allele Stage III Cutaneous Melanoma AJCC v7 Stage IIIA Cutaneous Melanoma AJCC v7 Stage IIIB Cutaneous Melanoma AJCC v7 Stage IIIC Cutaneous Melanoma AJCC v7 Stage IV Cutaneous Melanoma AJCC v6 and v7 Collapse << | Phase 2 | Recruiting | December 31, 2021 | United States, Texas ... more >> M D Anderson Cancer Center Recruiting Houston, Texas, United States, 77030 Contact: Hussein A. Tawbi 713-792-2921 Principal Investigator: Hussein A. Tawbi Collapse << |
| NCT00888134 | - | - | Completed | - | - |
| NCT03743298 | Metastatic Melanoma | Phase 1 | Not yet recruiting | January 2023 | - |
| NCT02231775 | BRAF V600E Mutation Present ... more >> BRAF V600K Mutation Present Stage IIIB Cutaneous Melanoma AJCC v7 Stage IIIC Cutaneous Melanoma AJCC v7 Collapse << | Phase 2 | Recruiting | October 31, 2019 | United States, Texas ... more >> M D Anderson Cancer Center Recruiting Houston, Texas, United States, 77030 Contact: Jennifer Wargo 713-745-1553 Principal Investigator: Jennifer Wargo Collapse << |
| NCT03543969 | Melanoma (Skin) ... more >> Skin Cancer Skin Melanoma Skin Carcinoma Collapse << | Early Phase 1 | Recruiting | September 2021 | United States, Florida ... more >> H. Lee Moffitt Cancer Center and Research Institute Recruiting Tampa, Florida, United States, 33612 Contact: Leticia Tetteh 813-745-4617 leticia.tetteh@moffitt.org Principal Investigator: Zeynep Eroglu, M.D. Collapse << |
| NCT01231594 | Cancer | Phase 1 | Completed | - | - |
| NCT03618641 | Melanoma Lymp... more >>h Node Cancer Collapse << | Phase 2 | Recruiting | July 15, 2023 | United States, Pennsylvania ... more >> UPMC Hillman Cancer Center Recruiting Pittsburgh, Pennsylvania, United States, 15232 Contact: Diwakar Davar, MD 412-623-7368 davard@upmc.edu Contact: Amy Rose, RN 412-647-8587 kennaj@upmc.edu Collapse << |
| NCT01689519 | Malignant Melanoma | Phase 3 | Active, not recruiting | December 28, 2019 | - |
| NCT01689519 | - | - | Active, not recruiting | - | - |
| NCT03580382 | Melanoma | Phase 1 Phase 2 | Recruiting | April 2022 | United States, New York ... more >> New York University School of Medicine Recruiting New York, New York, United States, 10016 Contact: Jennifer Tiao 929-455-2437 Jennifer.Tiao@nyumc.org Principal Investigator: Jeffrey Weber, MD Collapse << |
| NCT03430947 | Malignant Melanoma Stage IV ... more >> BRAF V600 Mutation Brain Metastases Collapse << | Phase 2 | Recruiting | August 31, 2021 | Germany ... more >> Technische Universität Dresden Recruiting Dresden, Germany, 01307 Contact: Friedegund Meier, MD +49 351 458 ext 2497 friedegund.meier@uniklinikum-dresden.de Contact: Esther Troost, MD +49 351 458 ext 2394 esther.troost@uniklinikum-dresden.de Principal Investigator: Friedegund Meier, MD Principal Investigator: Esther Troost, MD, PhD Ruprecht-Karls-University of Heidelberg, Faculty of Medicine Not yet recruiting Heidelberg, Germany, 69120 Contact: Jessica Hassel, MD Eberhard Karls University of Tübingen, University Medical Center Not yet recruiting Tuebingen, Germany, 72076 Contact: Thomas Eigentler, MD Collapse << |
| NCT01726738 | Stage III Melanoma ... more >> Stage IV Melanoma Unresectable Melanoma BRAF Mutant Melanoma Collapse << | Phase 2 | Completed | - | United States, North Carolina ... more >> Lineberger Comprehensive Cancer Center, University of North Carolina Chapel Hill, North Carolina, United States, 27599 Collapse << |
| NCT02224781 | BRAF NP_004324.2:p.V600X ... more >> Metastatic Melanoma Recurrent Melanoma Stage III Cutaneous Melanoma AJCC v7 Stage IIIA Cutaneous Melanoma AJCC v7 Stage IIIB Cutaneous Melanoma AJCC v7 Stage IIIC Cutaneous Melanoma AJCC v7 Stage IV Cutaneous Melanoma AJCC v6 and v7 Collapse << | Phase 3 | Recruiting | - | - |
| NCT01909453 | Melanoma | Phase 3 | Active, not recruiting | March 31, 2019 | - |
| NCT01701037 | Recurrent Melanoma ... more >> Stage IIB Melanoma (Locally Advanced) Stage IIC Melanoma (Locally Advanced) Stage IIIA Melanoma Stage IIIB Melanoma Stage IIIC Melanoma Stage IV Melanoma (Limited, Resectable) Collapse << | Phase 2 | Terminated(PI leaving VICC, lo... more >>w future accrual predicted, continued funding improbable,) Collapse << | - | United States, Tennessee ... more >> Vanderbilt-Ingram Cancer Center Nashville, Tennessee, United States, 37232-6838 Collapse << |
| NCT01701037 | - | - | Terminated(PI leaving VICC, lo... more >>w future accrual predicted, continued funding improbable,) Collapse << | - | - |
| NCT03026517 | Melanoma | Phase 1 | Recruiting | January 2020 | United States, Massachusetts ... more >> Massachusetts General Hospital Recruiting Boston, Massachusetts, United States, 02114 Contact: Keith Flaherty, MD 617-724-4800 United States, New York Memorial Sloan Kettering Westchester Recruiting Harrison, New York, United States, 10604 Contact: Paul Chapman, MD 646-888-4162 Memorial Sloan Kettering Cancer Center Recruiting New York, New York, United States, 10065 Contact: Paul Chapman, MD 646-888-4162 Contact: Michael Postow, MD 646-888-4589 Principal Investigator: Paul Chapman, MD Collapse << |
| NCT02196181 | BRAF V600E Mutation Present ... more >> BRAF V600K Mutation Present Stage III Cutaneous Melanoma AJCC v7 Stage IIIA Cutaneous Melanoma AJCC v7 Stage IIIB Cutaneous Melanoma AJCC v7 Stage IIIC Cutaneous Melanoma AJCC v7 Stage IV Cutaneous Melanoma AJCC v6 and v7 Unresectable Melanoma Collapse << | Phase 2 | Recruiting | - | - |
| NCT01231568 | Cancer | Phase 1 | Completed | - | United States, Arizona ... more >> GSK Investigational Site Scottsdale, Arizona, United States, 85259 United States, Michigan GSK Investigational Site Detroit, Michigan, United States, 48201 United States, Tennessee GSK Investigational Site Nashville, Tennessee, United States, 37203 United States, Utah GSK Investigational Site Salt Lake City, Utah, United States, 84112 Collapse << |
| NCT01840527 | - | - | Active, not recruiting | March 2019 | United States, Massachusetts ... more >> Massachusetts General Hospital Boston, Massachusetts, United States, 02114 Beth Israel Deaconess Medical Center Boston, Massachusetts, United States, 02215 Dana-Farber Cancer Institute Boston, Massachusetts, United States, 02215 Collapse << |
| NCT03181100 | Malignant Neoplasms of Thyroid... more >> and Other Endocrine Glands Anaplastic Thyroid Carcinoma Poorly Differentiated Thyroid Cancer Collapse << | Phase 2 | Recruiting | July 2023 | United States, Texas ... more >> University of Texas MD Anderson Cancer Center Recruiting Houston, Texas, United States, 77030 Contact: Clinical Research Operations mcabani@mdanderson.org Contact mcabani@mdanderson.org Collapse << |
| NCT03101254 | Melanoma | Phase 1 Phase 2 | Recruiting | October 30, 2023 | United States, Massachusetts ... more >> Dana Farber Cancer Institute Recruiting Boston, Massachusetts, United States, 02215 Contact: Elizabeth Buchcinder, MD 617-632-5055 Principal Investigator: Elizabeth Buchbinder, MD Collapse << |
| NCT02729298 | Advanced Solid Tumors ... more >> EGFR Positive Non-small Cell Lung Cancer Colorectal Carcinoma Recurrent Ovarian Carcinoma BRAF-Mutated Melanoma Collapse << | Phase 1 | Recruiting | September 2019 | United States, Arizona ... more >> Mayo Clinic Arizona Recruiting Phoenix, Arizona, United States, 85054 Contact: Debbie Gallagher, RN gallagher.deborah@mayo.edu Principal Investigator: Mahesh Seetharam, MD HonorHealth Research Institute Recruiting Scottsdale, Arizona, United States, 85258 Contact: Joyce Schaffer, RN 480-323-1339 clinicaltrials@honorhealth.com Principal Investigator: Vivek Khemka, MD United States, Florida Mayo Clinic Florida Recruiting Jacksonville, Florida, United States, 32224 Contact: Torsak Vimoktayon, MPH vimoktayon.torsak@mayo.edu Principal Investigator: YanYan Lou, MD United States, Minnesota Mayo Clinic Rochester Recruiting Rochester, Minnesota, United States, 55905 Contact: Danielle Sommerfeldt sommerfeldt.danielle@mayo.edu Principal Investigator: Alex Adjei, MD United States, Texas University of Texas Southwestern Medical Center Recruiting Dallas, Texas, United States, 75390 Contact: Yolanda Pitts yolanda.pitts@utsouthwestern.edu Principal Investigator: Muhammad Beg, MD University of Texas Science Center at San Antonio (UTHSCSA) Recruiting San Antonio, Texas, United States, 78229 Contact: CTRC 210-450-2872 Principal Investigator: John Sarantopoulos, MD Collapse << |
| NCT01723202 | Follicular Thyroid Cancer ... more >> Insular Thyroid Cancer Papillary Thyroid Cancer Recurrent Thyroid Cancer Collapse << | Phase 2 | Active, not recruiting | December 31, 2019 | United States, California ... more >> University of California, San Diego San Diego, California, United States, 92093-0698 United States, Illinois University of Chicago Medical Center Chicago, Illinois, United States, 60637 United States, Massachusetts Massachusetts General Hospital, Harvard Medical School Boston, Massachusetts, United States, 02114 United States, Ohio Ohio State University Medical Center Columbus, Ohio, United States, 43210 United States, Texas The University of Texas-MD Anderson Cancer Center Houston, Texas, United States, 77030 Collapse << |
| NCT01719380 | Colorectal Cancer | Phase 1 Phase 2 | Active, not recruiting | July 31, 2019 | - |
| NCT02306850 | Unresectable Malignant Neoplas... more >>m Melanoma Metastatic Melanoma Stage IV Melanoma Stage III Melanoma Collapse << | Phase 2 | Recruiting | February 2019 | United States, Missouri ... more >> Saint Louis University Hospital Recruiting Saint Louis, Missouri, United States, 63101 Contact: Debra L King, RN 314-268-7061 richartstudy@gmail.com Principal Investigator: John M Richart, M.D. Collapse << |
| NCT01738451 | Cancer | Phase 1 | Completed | - | United States, Arizona ... more >> GSK Investigational Site Scottsdale, Arizona, United States, 85259 United States, Tennessee GSK Investigational Site Memphis, Tennessee, United States, 38120 GSK Investigational Site Nashville, Tennessee, United States, 37203 United States, Texas GSK Investigational Site San Antonio, Texas, United States, 78229 United States, Utah GSK Investigational Site Salt Lake City, Utah, United States, 84112-5550 Australia, Victoria GSK Investigational Site Heidelberg, Victoria, Australia, 3084 GSK Investigational Site Melbourne, Victoria, Australia, 3004 United Kingdom GSK Investigational Site London, United Kingdom, W1G 6AD Collapse << |
| NCT01758575 | - | - | Terminated | - | Netherlands ... more >> VU University Medical Center Amsterdam, Netherlands, 1081HV Collapse << |
| NCT01585415 | Metastatic Cancer ... more >> Melanoma Collapse << | Phase 1 | Terminated | - | United States, Maryland ... more >> National Institutes of Health Clinical Center, 9000 Rockville Pike Bethesda, Maryland, United States, 20892 Collapse << |
| NCT03754179 | Melanoma | Phase 1 Phase 2 | Recruiting | December 1, 2020 | Belgium ... more >> UZ Brussel Recruiting Jette, Brabant, Belgium, 1090 Contact: Bart Neyns, Phd,Md 0032(0)2477 64 15 bart.neyns@uzbrussel.be Principal Investigator: Bart Neyns, Phd,Md Collapse << |
| NCT01700699 | - | - | Unknown | October 2013 | Italy ... more >> Department of Medicine and Surgery, Univeristy of Salerno Recruiting Baronissi, Salerno, Italy, 84081 Contact: Mario Vitale, MD +39 089672539 mavitale@unisa.it Principal Investigator: Mario Vitale, MD Collapse << |
| NCT01582997 | Cancer | Phase 1 | Completed | - | Japan ... more >> GSK Investigational Site Shizuoka, Japan, 411-8777 GSK Investigational Site Tokyo, Japan, 104-0045 Collapse << |
| NCT01262963 | Cancer | Phase 1 | Completed | - | United States, Washington ... more >> GSK Investigational Site Tacoma, Washington, United States, 98418 Collapse << |
| NCT02906059 | Metastatic Colorectal Cancer | Phase 1 | Recruiting | September 2019 | United States, New York ... more >> Laura and Isaac Perlmutter Cancer Center Recruiting New York, New York, United States, 10016 Contact: Deirdre Cohen, MD 212-731-5656 Deirdre.Cohen@nyumc.org Sub-Investigator: Ping Gu, MD Sub-Investigator: Cynthia Leichman, MD Sub-Investigator: Lawrence Leichman, MD Sub-Investigator: Theresa Ryan, MD Sub-Investigator: Jennifer Wu, MD Collapse << |
| NCT01902173 | Adult Solid Neoplasm ... more >> Recurrent Colon Carcinoma Recurrent Melanoma Recurrent Ovarian Carcinoma Stage IIIC Colon Cancer Stage IIIC Ovarian Cancer Stage IIIC Skin Melanoma Stage IV Skin Melanoma Collapse << | Phase 1 Phase 2 | Suspended(Temporarily stopped ... more >>for assessment. Contact ctsucontact@westat.com for specifics) Collapse << | - | United States, California ... more >> USC / Norris Comprehensive Cancer Center Los Angeles, California, United States, 90033 UCLA / Jonsson Comprehensive Cancer Center Los Angeles, California, United States, 90095 California Pacific Medical Center-Pacific Campus San Francisco, California, United States, 94115 UCSF Medical Center-Mount Zion San Francisco, California, United States, 94115 United States, Colorado University of Colorado Cancer Center - Anschutz Cancer Pavilion Aurora, Colorado, United States, 80045 United States, Michigan University of Michigan Comprehensive Cancer Center Ann Arbor, Michigan, United States, 48109 United States, Ohio Cleveland Clinic Foundation Cleveland, Ohio, United States, 44195 Ohio State University Comprehensive Cancer Center Columbus, Ohio, United States, 43210 United States, Oregon Clackamas Radiation Oncology Center Clackamas, Oregon, United States, 97015 Providence Milwaukie Hospital Milwaukie, Oregon, United States, 97222 Providence Newberg Medical Center Newberg, Oregon, United States, 97132 Providence Willamette Falls Medical Center Oregon City, Oregon, United States, 97045 Providence Portland Medical Center Portland, Oregon, United States, 97213 Providence Saint Vincent Medical Center Portland, Oregon, United States, 97225 Oregon Health and Science University Portland, Oregon, United States, 97239 United States, Washington PeaceHealth Southwest Medical Center Vancouver, Washington, United States, 98664 Collapse << |
| NCT02143050 | Melanoma | Phase 1 Phase 2 | Recruiting | June 2020 | United States, Kentucky ... more >> James Graham Brown Cancer Center-Universityof Louisville Recruiting Louisville, Kentucky, United States, 40202 Contact: Jason A Chesney, MD, PhD 502-562-3429 jason.chesney@louisville.edu Contact: Christina LaDuke 502-217-5205 christy.laduke@louisville.edu Sub-Investigator: Donald M Miller, MD, PhD Sub-Investigator: Kelly M McMasters, MD, PhD Sub-Investigator: Sucheta Telang, MD James Graham Brown Cancer Center Recruiting Louisville, Kentucky, United States, 40202 Contact: Karen Carter, BSN 502-562-3690 kmcart05@louisville.edu Contact: Christina LaDuke, BS 502-217-5205 christi.laduke@louisville.edu Collapse << |
| NCT01989585 | BRAF V600E Mutation Present ... more >> BRAF V600K Mutation Present Metastatic Melanoma Solid Neoplasm Stage III Cutaneous Melanoma AJCC v7 Stage IIIA Cutaneous Melanoma AJCC v7 Stage IIIB Cutaneous Melanoma AJCC v7 Stage IIIC Cutaneous Melanoma AJCC v7 Stage IV Cutaneous Melanoma AJCC v6 and v7 Collapse << | Phase 1 Phase 2 | Recruiting | - | United States, California ... more >> University of California Davis Comprehensive Cancer Center Suspended Sacramento, California, United States, 95817 United States, Massachusetts Massachusetts General Hospital Cancer Center Withdrawn Boston, Massachusetts, United States, 02114 United States, Missouri Siteman Cancer Center at West County Hospital Suspended Creve Coeur, Missouri, United States, 63141 Washington University School of Medicine Suspended Saint Louis, Missouri, United States, 63110 Siteman Cancer Center-South County Suspended Saint Louis, Missouri, United States, 63129 Siteman Cancer Center at Christian Hospital Suspended Saint Louis, Missouri, United States, 63136 Siteman Cancer Center at Saint Peters Hospital Suspended Saint Peters, Missouri, United States, 63376 United States, New Jersey Rutgers Cancer Institute of New Jersey Recruiting New Brunswick, New Jersey, United States, 08903 Contact: Site Public Contact 732-235-8675 Principal Investigator: Janice M. Mehnert United States, North Carolina Duke University Medical Center Recruiting Durham, North Carolina, United States, 27710 Contact: Site Public Contact 888-275-3853 Principal Investigator: James L. Abbruzzese United States, Ohio Ohio State University Comprehensive Cancer Center Recruiting Columbus, Ohio, United States, 43210 Contact: Site Public Contact 800-293-5066 Jamesline@osumc.edu Principal Investigator: Kari L. Kendra United States, Texas M D Anderson Cancer Center Recruiting Houston, Texas, United States, 77030 Contact: Site Public Contact 877-312-3961 Principal Investigator: Michael A. Davies Collapse << |
| NCT02836548 | Melanoma Skin... more >> Neoplasms Collapse << | Phase 1 Phase 2 | Recruiting | October 2019 | Netherlands ... more >> Netherlands Cancer Institute - Antoni van Leeuwenhoek Hospital Recruiting Amsterdam, Netherlands, 1066 CX Contact: N Steeghs, MD, PhD Collapse << |
| NCT00338377 | Melanoma | Phase 2 | Recruiting | February 2019 | United States, Texas ... more >> The University of Texas MD Anderson Cancer Center Recruiting Houston, Texas, United States, 77030 Contact: Patrick Hwu, MD 713-792-2921 phwu@mdanderson.org Principal Investigator: Patrick Hwu, MD Collapse << |
| NCT01940809 | BRAF V600E Mutation Present ... more >> BRAF V600K Mutation Present Metastatic Melanoma Stage III Cutaneous Melanoma AJCC v7 Stage IIIA Cutaneous Melanoma AJCC v7 Stage IIIB Cutaneous Melanoma AJCC v7 Stage IIIC Cutaneous Melanoma AJCC v7 Stage IV Cutaneous Melanoma AJCC v6 and v7 Collapse << | Phase 1 | Active, not recruiting | - | United States, Massachusetts ... more >> Brigham and Women's Hospital Boston, Massachusetts, United States, 02115 Dana-Farber Cancer Institute Boston, Massachusetts, United States, 02215 Collapse << |
| NCT01037127 | - | - | Completed | - | - |
| NCT01495988 | Melanoma Meta... more >>static Melanoma Collapse << | Phase 2 | Terminated(Slow accrual; toxic... more >>ity; change in priorities) Collapse << | - | United States, California ... more >> The Angeles Clinic Los Angeles, California, United States, 90025 United States, Colorado University of Colorado Cancer Center Aurora, Colorado, United States, 80045 United States, District of Columbia Georgetown Lombardi Comprehensive Cancer Center Washington, D.C., District of Columbia, United States, 20007 Washington Cancer Institute at MedStar Washington Hospital Center Washington, D.C., District of Columbia, United States, 20010 United States, Maryland Harry and Jeannette Weinberg Cancer Institute at Franklin Square Baltimore, Maryland, United States, 21237 United States, Massachusetts Massachusetts General Hospital Boston, Massachusetts, United States, 02114 Beth Israel Deaconess Medical Center (BIDMC) Boston, Massachusetts, United States, 02215 Dana-Farber Cancer Institute Boston, Massachusetts, United States, 02215 United States, New York NYU Clinical Cancer Center New York, New York, United States, 10016 Columbia University Medical Center New York, New York, United States, 10032 United States, Ohio OSU Comprehensive Cancer Center Columbus, Ohio, United States, 43210 United States, Pennsylvania University of Pittsburgh Medical Center Pittsburgh, Pennsylvania, United States, 15232 United States, Tennessee Vanderbilt-Ingram Cancer Center Nashville, Tennessee, United States, 37232 United States, Washington University of Washington Medical Center Seattle, Washington, United States, 98109 Collapse << |
| NCT01037127 | Cancer | Phase 2 | Completed | - | United States, California ... more >> GSK Investigational Site Los Angeles, California, United States, 90024 United States, Colorado GSK Investigational Site Aurora, Colorado, United States, 80045 United States, New York GSK Investigational Site New York, New York, United States, 10016 United States, Pennsylvania GSK Investigational Site Philadelphia, Pennsylvania, United States, 19104 United States, Tennessee GSK Investigational Site Nashville, Tennessee, United States, 37203 GSK Investigational Site Nashville, Tennessee, United States, 37232-6307 United States, Texas GSK Investigational Site Houston, Texas, United States, 77030-4009 Australia, New South Wales GSK Investigational Site Westmead, New South Wales, Australia, 2145 Australia, Victoria GSK Investigational Site East Melbourne, Victoria, Australia, 3002 Australia, Western Australia GSK Investigational Site Nedlands, Western Australia, Australia, 6009 Collapse << |
| NCT03493932 | Glioblastoma | Phase 1 | Recruiting | June 1, 2021 | United States, Maryland ... more >> National Institutes of Health Clinical Center Recruiting Bethesda, Maryland, United States, 20892 Contact: For more information at the NIH Clinical Center contact Office of Patient Recruitment (OPR) 800-411-1222 ext TTY8664111010 prpl@cc.nih.gov Collapse << |
| NCT01495988 | - | - | Terminated(Slow accrual; toxic... more >>ity; change in priorities) Collapse << | - | - |
| NCT01519427 | Recurrent Melanoma ... more >> Stage IIIA Melanoma Stage IIIB Melanoma Stage IIIC Melanoma Stage IV Melanoma Collapse << | Phase 2 | Terminated(Study terminated du... more >>e to slow accrual) Collapse << | - | United States, Georgia ... more >> Emory University Atlanta, Georgia, United States, 30322 United States, New Jersey Cancer Institute of New Jersey New Brunswick, New Jersey, United States, 08903 United States, Tennessee Vanderbilt-Ingram Cancer Center Nashville, Tennessee, United States, 37232 United States, Virginia Virginia Commonwealth University/Massey Cancer Center Richmond, Virginia, United States, 23298 Collapse << |
| NCT02354690 | Metastatic Melanoma | Phase 1 Phase 2 | Active, not recruiting | August 2020 | Denmark ... more >> Center for Cancer Immune Therapy, Dept. of Haematology/Oncology Copenhagen, Herlev, Denmark, 2730 Collapse << |
| NCT01584648 | Melanoma | Phase 3 | Active, not recruiting | October 15, 2018 | - |
| NCT01340833 | Cancer | Phase 1 | Completed | - | United States, Washington ... more >> GSK Investigational Site Tacoma, Washington, United States, 98418 Collapse << |
| NCT01584648 | - | - | Active, not recruiting | - | - |
| NCT02427893 | Melanoma | Phase 3 | Withdrawn(no patients were enr... more >>olled) Collapse << | - | United States, Maryland ... more >> The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins Baltimore, Maryland, United States, 21231 Collapse << |
| NCT01777776 | Locally Advanced Metastatic BR... more >>AF Mutant Melanoma Collapse << | Phase 1 Phase 2 | Terminated(Study was withdrawn... more >> due to scientific and business considerations.) Collapse << | - | United States, Colorado ... more >> University of Colorado Dept of Oncology Aurora, Colorado, United States, 80045 United States, Michigan Karmanos Cancer Institute Dept of Oncology Detroit, Michigan, United States, 48201 United States, New York Memorial Sloan Kettering Cancer Center Dept Oncology NY, New York, United States, 90033 United States, Oregon Oregon Health & Science University Dept. of OHSU (3) Portland, Oregon, United States, 97239 United States, Tennessee Vanderbilt University Medical Center SC - Dept of Oncology . Nashville, Tennessee, United States, 37232 Australia, New South Wales Novartis Investigative Site Westmead, New South Wales, Australia, 2145 Australia, South Australia Novartis Investigative Site Woodville, South Australia, Australia, 5011 Canada, Quebec Novartis Investigative Site Montreal, Quebec, Canada, H2X 3J4 Netherlands Novartis Investigative Site Utrecht, Netherlands, 3584CX Collapse << |
| NCT01777776 | - | - | Terminated(Study was withdrawn... more >> due to scientific and business considerations.) Collapse << | - | - |
| NCT01340846 | Cancer | Phase 1 | Completed | - | United States, Arizona ... more >> GSK Investigational Site Scottsdale, Arizona, United States, 85259 United States, Florida GSK Investigational Site Sarasota, Florida, United States, 34232 United States, Michigan GSK Investigational Site Detroit, Michigan, United States, 48201 United States, Ohio GSK Investigational Site Columbus, Ohio, United States, 43210 United States, Oklahoma GSK Investigational Site Oklahoma City, Oklahoma, United States, 73104 United States, South Carolina GSK Investigational Site Greenville, South Carolina, United States, 29605 United States, Tennessee GSK Investigational Site Nashville, Tennessee, United States, 37203 United States, Utah GSK Investigational Site Salt Lake City, Utah, United States, 84112 Australia, Western Australia GSK Investigational Site Nedlands, Western Australia, Australia, 6009 United Kingdom GSK Investigational Site Headington, United Kingdom, OX3 7LJ GSK Investigational Site London, United Kingdom, W1G 6AD Collapse << |
| NCT01519427 | - | - | Terminated(Study terminated du... more >>e to slow accrual) Collapse << | - | - |
| NCT02314143 | Melanoma | Phase 2 | Completed | - | France ... more >> GSK Investigational Site Bordeaux, France, 33075 GSK Investigational Site Marseille cedex 5, France, 13385 GSK Investigational Site Reims Cedex, France, 51092 GSK Investigational Site Rennes Cedex, France, 35042 GSK Investigational Site Villejuif cedex, France, 94805 Spain GSK Investigational Site Barcelona, Spain, 08036 GSK Investigational Site Madrid, Spain, 28041 Collapse << |
| NCT02097225 | BRAF V600E Mutation Present ... more >> BRAF V600K Mutation Present Metastatic Malignant Solid Neoplasm Metastatic Melanoma Stage III Cutaneous Melanoma AJCC v7 Stage IIIA Cutaneous Melanoma AJCC v7 Stage IIIB Cutaneous Melanoma AJCC v7 Stage IIIC Cutaneous Melanoma AJCC v7 Stage IV Cutaneous Melanoma AJCC v6 and v7 Unresectable Solid Neoplasm Collapse << | Phase 1 | Recruiting | - | United States, Massachusetts ... more >> Massachusetts General Hospital Cancer Center Recruiting Boston, Massachusetts, United States, 02114 Contact: Ryan J. Sullivan 617-724-4000 rsullivan7@partners.org Principal Investigator: Ryan J. Sullivan Dana-Farber Cancer Institute Suspended Boston, Massachusetts, United States, 02215 Collapse << |
| NCT01713972 | Unspecified Adult Solid Tumor,... more >> Protocol Specific Collapse << | Phase 1 | Active, not recruiting | December 31, 2019 | United States, Ohio ... more >> Ohio State University Medical Center Columbus, Ohio, United States, 43210 United States, Texas University of Texas M.D. Anderson Cancer Center Houston, Texas, United States, 77030 Collapse << |
| NCT03088176 | Melanoma BRAF... more >> Gene Mutation Collapse << | Phase 1 | Recruiting | June 30, 2021 | United States, Tennessee ... more >> West Cancer Center Recruiting Germantown, Tennessee, United States, 38138 Contact: Ari VanderWalde, MD, MPH 901-683-0055 ext 63015 avanderw@westclinic.com Contact: Nibedita Chakraborty 901-683-0055 ext 63023 nchakraborty@westclinic.com Collapse << |
| NCT02475213 | Melanoma Head... more >> and Neck Cancer Non Small Cell Lung Cancer Urethelial Carcinoma Collapse << | Phase 1 | Recruiting | August 2020 | United States, Arizona ... more >> Mayo Clinic - AZ Not yet recruiting Scottsdale, Arizona, United States, 85259 Principal Investigator: Ramesh Ramanathan, MD United States, Florida Boca Raton Regional Hospital Not yet recruiting Boca Raton, Florida, United States, 33486 Principal Investigator: Edgardo Santos Castillero, MD Mayo Clinic - FL Not yet recruiting Jacksonville, Florida, United States, 32224 Principal Investigator: Yanyan Lou, MD, PhD Moffitt Cancer Center Recruiting Tampa, Florida, United States, 33612 Contact: Kristina Trajic 813-745-4673 ext 1480 Kristina.trajic@moffitt.org Principal Investigator: Scott Antonia, MD United States, Kentucky Norton Cancer Institute Research Program Active, not recruiting Louisville, Kentucky, United States, 40202 United States, Maryland University of Maryland Greenbaum Cancer Center Recruiting Baltimore, Maryland, United States, 21201 Contact: Cheryl Young Cheryl.Young@umm.edu Principal Investigator: Dan Zandberg, MD United States, Massachusetts Dana-Farber Cancer Institute Recruiting Boston, Massachusetts, United States, 02215 Contact: Tess Ferguson 617-632-1991 tessk_ferguson@dfci.harvard.edu Principal Investigator: Osama Rahma, MD United States, Michigan South Texas Accelerated Research Therapeutics, LLC - Midwest Recruiting Grand Rapids, Michigan, United States, 49503 Contact: Kathy Estkowski 616-954-5551 kathy.estkowski@startmidwest.com Principal Investigator: Nehal Lakhani, MD, PhD United States, Minnesota Mayo Clinic - MN Not yet recruiting Rochester, Minnesota, United States, 55905 Principal Investigator: Alex Adjei, MD, PhD United States, Nebraska Nebraska Cancer Specialists Recruiting Omaha, Nebraska, United States, 68130 Contact: Gladys Pierce 402-690-6972 gpierce@nebraskacancer.com Principal Investigator: Ralph Hauke, MD United States, Nevada Comprehensive Cancer Centers of Nevada Recruiting Las Vegas, Nevada, United States, 89169 Contact: Kim Bradstreet, RN 702-952-3443 kimberly.bradstreet@usoncology.com Principal Investigator: Nicholas Vogelzang, MD United States, New York Roswell Park Cancer Institute Not yet recruiting Buffalo, New York, United States, 14263 Contact: Dawn DePaolo DawnMarie.DePaolo@RoswellPark.org Principal Investigator: Gurkamal Chatta, MD Columbia University Medical Center Recruiting New York, New York, United States, 10032 Contact: Molly McGuinness 212-304-5552 mm5016@cumc.columbia.edu Principal Investigator: Naiyer Rizvi, MD United States, Ohio Gabrail Cancer Institute Not yet recruiting Canton, Ohio, United States, 44718 Principal Investigator: Nashat Gabrail, MD United States, Pennsylvania Hospital of the University of Pennsylvania/Abramson Cancer Center Recruiting Philadelphia, Pennsylvania, United States, 19104 Contact: Maryann Ghallagher, RN 215-662-7758 maryann.gallagher@uphs.upenn.edu Principal Investigator: Charu Aggarwal, MD University of Pittsburg Recruiting Pittsburgh, Pennsylvania, United States, 15232 Contact: Shea McQuilkin, BSN, RN 412-623-6650 mcquilkinm@upmc.edu Principal Investigator: Robert Ferris, MD United States, Rhode Island Rhode Island Hospital Not yet recruiting Providence, Rhode Island, United States, 02903 Principal Investigator: Ariel Birnbaum, MD United States, South Carolina Greenville Health System Not yet recruiting Greenville, South Carolina, United States, 29605 Contact: Lisa Johnson 864-455-3735 ljohnson4@ghs.org Principal Investigator: Jeffery Edenfield, MD United States, Texas Mary Crowley Cancer Research Center Not yet recruiting Dallas, Texas, United States, 75230 Principal Investigator: James Strauss, MD South Texas Accelerated Research Therapeutics, LLC Recruiting San Antonio, Texas, United States, 78229 Contact: Christina Duralde, RN, MSN 210-593-5242 christina.duralde@start.stoch.com Principal Investigator: Anthony Tolcher, M.D. Collapse << |
| NCT02382549 | Melanoma | Phase 1 Phase 2 | Recruiting | June 2020 | United States, Virginia ... more >> Cancer Center at the University of Virginia Recruiting Charlottesville, Virginia, United States, 22908 Collapse << |
| NCT01907802 | BRAF Gene Mutation ... more >> Hepatic Complication Renal Failure Solid Neoplasm Collapse << | Phase 1 | Terminated | - | United States, California ... more >> City of Hope Comprehensive Cancer Center Duarte, California, United States, 91010 USC / Norris Comprehensive Cancer Center Los Angeles, California, United States, 90033 University of California Davis Comprehensive Cancer Center Sacramento, California, United States, 95817 City of Hope South Pasadena South Pasadena, California, United States, 91030 United States, Colorado University of Colorado Hospital Aurora, Colorado, United States, 80045 United States, Florida Mayo Clinic in Florida Jacksonville, Florida, United States, 32224-9980 United States, Illinois University of Chicago Comprehensive Cancer Center Chicago, Illinois, United States, 60637 United States, Maryland Johns Hopkins University/Sidney Kimmel Cancer Center Baltimore, Maryland, United States, 21287 United States, Massachusetts Dana-Farber Cancer Institute Boston, Massachusetts, United States, 02215 United States, Michigan Wayne State University/Karmanos Cancer Institute Detroit, Michigan, United States, 48201 United States, Minnesota Mayo Clinic Rochester, Minnesota, United States, 55905 United States, Missouri Washington University School of Medicine Saint Louis, Missouri, United States, 63110 United States, New Jersey Rutgers Cancer Institute of New Jersey New Brunswick, New Jersey, United States, 08903 United States, Ohio Case Western Reserve University Cleveland, Ohio, United States, 44106 Ohio State University Comprehensive Cancer Center Columbus, Ohio, United States, 43210 United States, Pennsylvania University of Pittsburgh Cancer Institute (UPCI) Pittsburgh, Pennsylvania, United States, 15232 United States, Wisconsin University of Wisconsin Hospital and Clinics Madison, Wisconsin, United States, 53792 Canada, Ontario University Health Network-Princess Margaret Hospital Toronto, Ontario, Canada, M5G 2M9 Collapse << |
| NCT01072175 | Cancer | Phase 2 | Completed | - | United States, California ... more >> Novartis Investigative Site Los Angeles, California, United States, 90025 Novartis Investigative Site San Francisco, California, United States, 94115 United States, Colorado Novartis Investigative Site Aurora, Colorado, United States, 80045 United States, Connecticut Novartis Investigative Site New Haven, Connecticut, United States, 06520 United States, Florida Novartis Investigative Site Tampa, Florida, United States, 33612 United States, Maryland Novartis Investigative Site Lutherville-Timonium, Maryland, United States, 21093 United States, Massachusetts Novartis Investigative Site Boston, Massachusetts, United States, 02114 Novartis Investigative Site Boston, Massachusetts, United States, 02215 United States, Minnesota Novartis Investigative Site Rochester, Minnesota, United States, 55905 United States, Pennsylvania Novartis Investigative Site Philadelphia, Pennsylvania, United States, 19104 United States, Tennessee Novartis Investigative Site Nashville, Tennessee, United States, 37203 Novartis Investigative Site Nashville, Tennessee, United States, 37232 United States, Texas Novartis Investigative Site Houston, Texas, United States, 77030-4009 Australia, New South Wales Novartis Investigative Site Westmead, New South Wales, Australia, 2145 Australia, Victoria Novartis Investigative Site Heidelberg, Victoria, Australia, 3084 Collapse << |
| NCT01754376 | Melanoma | Phase 2 | Terminated(changes in availabl... more >>e treatments for melanoma) Collapse << | - | United States, Massachusetts ... more >> Massachusetts General Hospital Boston, Massachusetts, United States, 02113 Beth Israel Deaconess Medical Center Boston, Massachusetts, United States, 02215 Collapse << |
| NCT02649972 | Histiocytic Disorders | Phase 2 | Recruiting | January 2019 | United States, New York ... more >> Memoral Sloan Kettering Cancer Center Recruiting New York, New York, United States, 10065 Contact: Eli Diamond, MD 212-639-7576 Contact: David Hyman, MD 646-888-4544 Principal Investigator: Eli Diamond, MD Collapse << |
| NCT01143753 | Neoplasms | Phase 1 | Completed | - | Australia, South Australia ... more >> Royal Adelaide Hospital; Oncology Adelaide, South Australia, Australia, 5000 Australia, Victoria Austin Hospital; Medical Oncology Heidelberg, Victoria, Australia, 3084 Royal Melbourne Hospital; Hematology and Medical Oncology Parkville, Victoria, Australia, 3052 Denmark Rigshospitalet, Onkologisk Klinik København Ø, Denmark, 2100 Spain Hospital Univ Vall d'Hebron; Servicio de Oncologia Barcelona, Spain, 08035 Collapse << |
| NCT01597908 | - | - | Active, not recruiting | - | - |
| NCT01754376 | - | - | Terminated(changes in availabl... more >>e treatments for melanoma) Collapse << | - | - |
| NCT01943422 | Melanoma | Phase 1 | Completed | - | United States, Pennsylvania ... more >> Hillman Cancer Center Pittsburgh, Pennsylvania, United States, 15232 Collapse << |
| NCT02281760 | BRAF V600E Mutation | Phase 2 | Completed | - | United States, Maryland ... more >> National Institutes of Health Clinical Center, 9000 Rockville Pike Bethesda, Maryland, United States, 20892 Collapse << |
| NCT02902042 | Malignant Melanoma | Phase 1 Phase 2 | Recruiting | March 2022 | Germany ... more >> Universitätsklinikum Freiburg Active, not recruiting Freiburg, Baden-Württemberg, Germany, 79106 Klinikum Augsburg Süd Not yet recruiting Augsburg, Bavaria, Germany, 86179 Principal Investigator: Christiane Pfeiffer, PD Dr. med. Klinikum rechts der Isar Recruiting München, Bavaria, Germany, 81675 Principal Investigator: Angela Krackhardt, Prof.Dr.med. Klinikum Nürnberg Nord Recruiting Nürnberg, Bavaria, Germany, 90419 Principal Investigator: Erwin S. Schultz, Prof.Dr.med. Vivantes Klinikum im Friedrichshain Active, not recruiting Berlin Friedrichshain, Berlin, Germany, 10249 Universitätsklinikum der RWTH Aachen Not yet recruiting Aachen, Nordrhein-Westfalen, Germany, 52074 Principal Investigator: Albert Rübben, Prof.Dr.med. University Hospital Essen, Department of Dermatology, Skin Cancer Center Recruiting Essen, North Rhine-Westphalia, Germany, 45122 Contact: Dirk Schadendorf, Prof. Dr. +49 (0) 201-723 ext 4342 dirk.schadendorf@uk-essen.de Principal Investigator: Dirk Schadendorf, Prof. Dr. Sub-Investigator: Lisa Zimmer, Dr. med. Sub-Investigator: Elisabeth Livingstone, Dr. med. HELIOS Klinikum Krefeld Recruiting Krefeld, North Rhine-Westphalia, Germany, 47805 Principal Investigator: Chalid Assaf, PD Dr. med. Gesellschaft für Klinische Forschung Ludwigshafen mbH Not yet recruiting Ludwigshafen am Rhein, Rheinland-Pfalz, Germany, 67063 Principal Investigator: Edgar Dippel, Prof.Dr.med. Städtisches Klinikum Dessau Recruiting Dessau, Saxony-Anhalt, Germany, 06847 Principal Investigator: Dietrich Trebing, Dr. med. Collapse << |
| NCT01619774 | Melanoma | Phase 2 | Completed | - | United States, Texas ... more >> University of Texas MD Anderson Cancer Center Houston, Texas, United States, 77030 Collapse << |
| NCT01947023 | BRAF V600E Mutation Present ... more >> BRAF V600K Mutation Present Metastatic Thyroid Gland Carcinoma Unresectable Thyroid Gland Carcinoma Collapse << | Phase 1 | Active, not recruiting | - | United States, New York ... more >> Memorial Sloan Kettering Cancer Center New York, New York, United States, 10065 Collapse << |
| NCT03410875 | Hairy Cell Leukemia ... more >> Leukemia Leukemia, Hairy Cell Collapse << | Phase 2 | Recruiting | January 2020 | United States, Connecticut ... more >> Yale University Not yet recruiting New Haven, Connecticut, United States, 06511 Contact: Gottfried von Keudell, MD/PhD 203-737-5312 United States, Massachusetts Dana Farber Cancer Institute Not yet recruiting Boston, Massachusetts, United States, 02115 Contact: Eric Winer, MD 617-632-6876 United States, New York Memorial Sloan - Kettering Cancer Center Recruiting New York, New York, United States, 10021 Contact: Jae Park, MD 212-639-4048 parkj6@mskcc.org Collapse << |
| NCT01835184 | Recurrent Melanoma ... more >> Stage IIIA Melanoma Stage IIIB Melanoma Stage IIIC Melanoma Stage IV Melanoma Unspecified Adult Solid Tumor, Protocol Specific Collapse << | Phase 1 | Terminated | - | United States, Georgia ... more >> Emory University/Winship Cancer Institute Atlanta, Georgia, United States, 30322 United States, Massachusetts Dana-Farber Cancer Institute Boston, Massachusetts, United States, 02115 United States, Virginia Virginia Commonwealth University Richmond, Virginia, United States, 23298 Collapse << |
| NCT01596140 | Advanced Cancer ... more >> Solid Tumor Collapse << | Phase 1 | Active, not recruiting | December 2020 | United States, Texas ... more >> University of Texas MD Anderson Cancer Center Houston, Texas, United States, 77030 Collapse << |
| NCT01826448 | V600-mutated BRAF Unresectable... more >> Melanoma V600-mutated BRAF Metastatic Melanoma Stage III or Stage IV Metastatic Melanoma That Has Not Been Previously Treated With a Selective BRAF Inhibitor Collapse << | Phase 1 | Terminated | - | United States, California ... more >> UCLA Los Angeles, California, United States, 90024 United States, Colorado University of Colorado, Denver Aurora, Colorado, United States, 80012 United States, Tennessee Vanderbilt University Nashville, Tennessee, United States, 37232 United States, Washington Seattle Cancer Care Alliance Seattle, Washington, United States, 98109 France Institute Gustave Roussy Paris, France Germany University Hospital Essen Essen, Germany Collapse << |
| NCT01597908 | Melanoma | Phase 3 | Active, not recruiting | March 18, 2019 | - |
| NCT01072175 | - | - | Completed | - | - |
| NCT01400451 | Melanoma | Phase 1 | Terminated(More than 2 of 6 pa... more >>tients treated experienced dose limiting toxicities.) Collapse << | - | United States, California ... more >> University Of California Los Angeles Los Angeles, California, United States, 90095 United States, Massachusetts Dana Farber Cancer Institute Boston, Massachusetts, United States, 02215 Dana Farber Cancer Inst Boston, Massachusetts, United States, 02215 United States, New York Memorial Sloan-Kettering Cancer Center New York, New York, United States, 10065 Collapse << |
| NCT01619774 | - | - | Completed | - | - |
| NCT01603212 | Melanoma | Phase 1 Phase 2 | Completed | - | United States, Texas ... more >> University of Texas MD Anderson Cancer Center Houston, Texas, United States, 77030 Collapse << |
| NCT02456701 | Thyroid Cancer | Phase 1 | Completed | - | United States, New York ... more >> Memorial Sloan-Kettering Cancer Center New York, New York, United States, 10065 Collapse << |
| NCT02089724 | - | - | Recruiting | April 2019 | United States, New York ... more >> Memorial Sloan Kettering Cancer Center Recruiting New York, New York, United States, 10065 Contact: Eli L. Diamond, MD, PhD diamonel@mskcc.org Principal Investigator: Eli L. Diamond, MD, PhD Sub-Investigator: Omar Abdel-Wahab, MD France AP-HP, Groupe Hospitalier Pitié-Salpêtrière Recruiting Paris, France, 75013 Contact: Julien Haroche, MD, PhD +33 1 42 17 80 37 julien.haroche@psl.aphp.fr Contact: Fleur Cohen Aubart, MD, PhD +33 1 42 17 82 42 fleur.cohen@psl.aphp.fr Principal Investigator: Julien Haroche, MD, PhD Sub-Investigator: Fleur Cohen Aubart, MD, PhD Sub-Investigator: Zahir Amoura, MD, MSc Collapse << |
| NCT01531361 | Advanced Malignant Neoplasm ... more >> BRAF Gene Mutation Metastatic Malignant Neoplasm Recurrent Malignant Neoplasm Refractory Malignant Neoplasm Collapse << | Phase 1 | Active, not recruiting | February 28, 2020 | United States, Texas ... more >> M D Anderson Cancer Center Houston, Texas, United States, 77030 Collapse << |
| NCT02610361 | Solid Tumors | Phase 1 | Completed | - | Australia, New South Wales ... more >> Chris O'Brien Lifehouse Camperdown, New South Wales, Australia, 2050 North Coast Cancer Institute Port Macquarie, New South Wales, Australia, 2444 Prince of Wales Hospital Randwick, New South Wales, Australia, 2031 Westmead Hospital Westmead, New South Wales, Australia, 2145 Australia, Queensland Tasman Oncology Research Ltd Southport, Queensland, Australia, 4215 Princess Alexandra Hospital Woolloongabba, Queensland, Australia, 4102 Australia, South Australia Royal Adelaide Hospital Adelaide, South Australia, Australia, 5000 The Queen Elizabeth Hospital Woodville South, South Australia, Australia, 5011 Australia, Victoria Box Hill Hospital Box Hill, Victoria, Australia, 3128 Monash Medical Centre Clayton, Victoria, Australia, 3168 Austin Health Heidelberg, Victoria, Australia Cabrini Hospital Malvern, Victoria, Australia, 3144 The Alfred Hospital Melbourne, Victoria, Australia, 3004 Peter MacCallum Cancer Centre Melbourne, Victoria, Australia Royal Melbourne Hospital Parkville, Victoria, Australia Australia, Western Australia Linear Clinical Research Limited Nedlands, Western Australia, Australia, 6009 New Zealand Christchurch Hospital Christchurch, New Zealand, 8011 Dunedin Public Hospital Dunedin, New Zealand, 9106 Waikato Hospital Hamilton, New Zealand Wellington Hospital Wellington, New Zealand Collapse << |
| NCT01400451 | - | - | Terminated(More than 2 of 6 pa... more >>tients treated experienced dose limiting toxicities.) Collapse << | - | - |
| NCT02967692 | Melanoma | Phase 3 | Recruiting | February 13, 2020 | - |
| NCT01767454 | Solid Tumours | Phase 1 | Completed | - | United States, California ... more >> GSK Investigational Site Los Angeles, California, United States, 90025 GSK Investigational Site San Francisco, California, United States, 94115 United States, Massachusetts GSK Investigational Site Boston, Massachusetts, United States, 02215 United States, Missouri GSK Investigational Site Saint Louis, Missouri, United States, 63110 United States, New York GSK Investigational Site New York, New York, United States, 10065 United States, Tennessee GSK Investigational Site Nashville, Tennessee, United States, 37232 United States, Texas GSK Investigational Site Houston, Texas, United States, 77030 Collapse << |
| NCT00880321 | Cancer | Phase 1 | Completed | - | United States, California ... more >> GSK Investigational Site Los Angeles, California, United States, 90025 United States, New York GSK Investigational Site New York, New York, United States, 10016 United States, Tennessee GSK Investigational Site Nashville, Tennessee, United States, 37203 United States, Texas GSK Investigational Site Houston, Texas, United States, 77030 Australia, New South Wales GSK Investigational Site Randwick, New South Wales, Australia, 2031 GSK Investigational Site Westmead, New South Wales, Australia, 2145 Australia, South Australia GSK Investigational Site Adelaide, South Australia, Australia, 5000 Australia, Western Australia GSK Investigational Site Nedlands, Western Australia, Australia, 6009 Collapse << |
| NCT01841463 | Advanced or Inoperable Maligna... more >>nt Melanoma With BRAF Mutation Collapse << | Phase 1 | Suspended(Sponsor decision not... more >> related to patient safety) Collapse << | March 2016 | United States, California ... more >> UCSF Medical Center at Mount Zion South San Francisco, California, United States, 94115 United States, Colorado University of Colorado Anschutz Medical Campus Aurora, Colorado, United States, 80045 United States, District of Columbia Georgetown-Lombardi Comprehensive Cancer Ctr Washington, District of Columbia, United States, 20057 United States, Texas The University of Texas, MD Anderson Cancer Center Houston, Texas, United States, 77030 Collapse << |
| NCT01750918 | Cancer | Phase 2 | Active, not recruiting | April 30, 2019 | United States, Arizona ... more >> Novartis Investigative Site Scottsdale, Arizona, United States, 85259 United States, California Novartis Investigative Site San Francisco, California, United States, 94115 United States, Massachusetts Novartis Investigative Site Boston, Massachusetts, United States, 02114 Novartis Investigative Site Boston, Massachusetts, United States, 02215 United States, New York Novartis Investigative Site New York, New York, United States, 10065 United States, North Carolina Novartis Investigative Site Chapel Hill, North Carolina, United States, 27599 United States, Pennsylvania Novartis Investigative Site Philadelphia, Pennsylvania, United States, 19104 United States, Tennessee Novartis Investigative Site Nashville, Tennessee, United States, 37203 Belgium Novartis Investigative Site Bruxelles, Belgium, 1200 Novartis Investigative Site Leuven, Belgium, 3000 France Novartis Investigative Site Paris cedex 12, France, 75571 Novartis Investigative Site Villejuif Cedex, France, 94805 Italy Novartis Investigative Site Milano, Lombardia, Italy, 20162 Novartis Investigative Site Candiolo (TO), Piemonte, Italy, 10060 Japan Novartis Investigative Site Aichi, Japan, 464-8681 Novartis Investigative Site Chiba, Japan, 277-8577 Netherlands Novartis Investigative Site Amsterdam, Netherlands, 1066 CX Novartis Investigative Site Utrecht, Netherlands, 3584 CX Spain Novartis Investigative Site Barcelona, Spain, 08035 United Kingdom Novartis Investigative Site Birmingham, United Kingdom, B15 2TH Collapse << |
| NCT01616199 | Advanced BRAF-mutant Cancers | Phase 1 Phase 2 | Terminated(slow accrual) | - | United States, Florida ... more >> H. Lee Moffitt Cancer Center Tampa, Florida, United States, 33612 United States, New York New York University New York, New York, United States, 10016 United States, Pennsylvania University of Pennsylvania Philadelphia, Pennsylvania, United States, 19104 University of Pittsburgh Cancer Institute Pittsburgh, Pennsylvania, United States, 15232 United States, Tennessee Vanderbilt-Ingram Cancer Center Nashville, Tennessee, United States, 37232 Collapse << |
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