|4-(5-(6-((6-甲氧基吡啶-3-基)甲基)-3,6-二氮杂双环[3.1.1]庚烷-3-基)吡嗪-2-基)-6-((R)-吗啉-2-基甲氧基)吡唑并[1,5-a]吡啶-3-甲腈|CsnPharm

CAS No.: 2222755-14-6

Synonyms: ARRY-192;GUN-55146

LOXO-292 is a RET kinase inhibitor with IC50s of 1 nM, 7 nM, and 101 nM for RET (WT), RET (V804M) , and RET (G810R), respectively .

规格	价格	促销价格	库存	数量

400-920-2911

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400-920-2911

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描述RET fusions are validated therapeutic targets in human lung cancers. LOXO292 is a potent and highly selective RET inhibitor with IC50 values of 1nM, 7nM and 101nM for RET(WT), RET(V804M) and RET(G810R), respectively. It exhibited anti-tumor activity in the brain and periphery in RET-dependent tumor models in vivo.
动物研究
剂量
Nude Mice: 3 mg/kg - 50 mg/kg^[1] (p.o., BID)

给药途径
p.o.

动物研究
剂量	Nude Mice: 3 mg/kg - 50 mg/kg^[1] (p.o., BID)
给药途径	p.o.

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