生物活性

• 描述Sabarubicin is a Top II inhibitor with anticancer activity.
• 临床研究

• NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
  NCT00003028	Unspecified Adult Solid Tumor,... more >> Protocol Specific Collapse <<	Phase 1	Completed	-	-
  NCT00027781	Prostate Cancer	Phase 2	Completed	-	Belgium ... more >> Universitair Ziekenhuis Antwerpen Edegem, Belgium, B-2650 France Institut Bergonie Bordeaux, France, 33076 Centre Jean Perrin Clermont-Ferrand, France, 63011 Centre de Lutte Contre le Cancer, Georges-Francois Leclerc Dijon, France, 21079 CHU de la Timone Marseille, France, 13385 CHU Pitie-Salpetriere Paris, France, 75651 Germany Universitaets-Krankenhaus Eppendorf Hamburg, Germany, D-20246 Israel Rabin Medical Center - Beilinson Campus Petah-Tikva, Israel, 49100 Spain Hospital Universitario 12 de Octubre Madrid, Spain, 28041 Switzerland Inselspital, Bern Bern, Switzerland, CH-3010 Collapse <<
  NCT00003982	Testicular Germ Cell Tumor ... more >> Unspecified Adult Solid Tumor, Protocol Specific Collapse <<	Phase 1	Completed	-	Austria ... more >> Innsbruck Universitaetsklinik Innsbruck, Austria, A-6020 Kaiser Franz Josef Hospital Vienna, Austria, A-1100 Belgium Institut Jules Bordet Brussels, Belgium, 1000 Ludwig Institute for Cancer Research-Brussels Branch Brussels, Belgium, B-1200 Universitair Ziekenhuis Antwerpen Edegem, Belgium, B-2650 U.Z. Gasthuisberg Leuven, Belgium, B-3000 Denmark Herlev Hospital - University Hospital of Copenhagen Herlev, Denmark, DK-2730 France Centre Jean Perrin Clermont-Ferrand, France, 63011 Centre Leon Berard Lyon, France, 69373 CRLCC Nantes - Atlantique Nantes-Saint Herblain, France, 44805 Institut Claudius Regaud Toulouse, France, 31052 Institut Gustave Roussy Villejuif, France, F-94805 Germany Universitaetsklinik und Strahlenklinik - Essen Essen, Germany, D-45122 Klinikum Nurnberg Nuremberg (Nurnberg), Germany, D-90419 Netherlands Antoni van Leeuwenhoekhuis Amsterdam, Netherlands, 1066 CX Academisch Ziekenhuis der Vrije Universiteit Amsterdam, Netherlands, 1117 MB Academisch Ziekenhuis Groningen Groningen, Netherlands, 9713 EZ University Medical Center Nijmegen Nijmegen, Netherlands, NL-6252 HB Rotterdam Cancer Institute Rotterdam, Netherlands, 3075 EA Norway Norwegian Radium Hospital Oslo, Norway, N-0310 Switzerland University Hospital Basel, Switzerland, CH-4031 Inselspital, Bern Bern, Switzerland, CH-3010 Kantonsspital - Saint Gallen Saint Gallen, Switzerland, CH-9007 United Kingdom Newcastle General Hospital Newcastle Upon Tyne, England, United Kingdom, NE4 6BE Ninewells Hospital and Medical School Dundee, Scotland, United Kingdom, DD1 9SY Western General Hospital Edinburgh, Scotland, United Kingdom, EH4 9NQ C.R.C. Beatson Laboratories Glasgow, Scotland, United Kingdom, G61 1BD Collapse <<

• 参考文献

• [1] Mazzini S, Scaglioni L, et al. Interaction between double helix DNA fragments and the new antitumor agent sabarubicin, Men10755. Bioorg Med Chem. 2010 Feb 15;18(4):1497-506.

  [2] Bressan A, Nardelli F, et al. Sabarubicin (MEN10755)-induced apoptosis is independent from mtDNA in A2780 human ovarian tumor cells. Anticancer Res. 2007 Nov-Dec;27(6B):4039-46.