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CAS No.: 912545-86-9
Synonyms: Smoothened Agonist
SAG is a potent Smo receptor agonist, and activates the Hedgehog signaling pathway, with Kd of 59 nM.
生物活性
NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
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NCT03704922 | Sickle Cell Disease | Phase 2 Phase 3 | Recruiting | March 30, 2021 | United States, Wisconsin ... more >> BloodCenter of Wisconsin Recruiting Milwaukee, Wisconsin, United States, 53226 Contact: Steven Frymark 414-937-6814 steven.frymark@bcw.edu Contact: Sarah Beggi 414-937-6457 sarah.beggi@bcw.edu Collapse << |
NCT01907100 | Mesothelioma | Phase 3 | Completed | - | - |
NCT02195518 | Hepatitis B, Chronic | Phase 4 | Completed | - | China, Guangdong ... more >> GSK Investigational Site Guangzhou, Guangdong, China, 510060 GSK Investigational Site Guangzhou, Guangdong, China, 510150 China, Jilin GSK Investigational Site Changchun, Jilin, China China, Sichuan GSK Investigational Site Chengdu, Sichuan, China, 610041 China, Zhejiang GSK Investigational Site Hangzhou, Zhejiang, China, 310000 China GSK Investigational Site Beijing, China, 100034 GSK Investigational Site Beijing, China, 100044 GSK Investigational Site Beijing, China, 100050 GSK Investigational Site Beijing, China, 100054 GSK Investigational Site Shanghai, China, 200025 GSK Investigational Site Shanghai, China, 200040 GSK Investigational Site Zhengzhou, China Collapse << |
实验方案
技术信息
CAS号 | 912545-86-9 | 储存条件 |
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分子式 | C28H28ClN3OS | 运输 | 蓝冰 | |||
分子量 | 490.06 | 别名 | Smoothened Agonist | |||
溶解度 |
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动物实验配方 |
NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
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NCT03704922 | Sickle Cell Disease | Phase 2 Phase 3 | Recruiting | March 30, 2021 | United States, Wisconsin ... more >> BloodCenter of Wisconsin Recruiting Milwaukee, Wisconsin, United States, 53226 Contact: Steven Frymark 414-937-6814 steven.frymark@bcw.edu Contact: Sarah Beggi 414-937-6457 sarah.beggi@bcw.edu Collapse << |
NCT01907100 | Mesothelioma | Phase 3 | Completed | - | - |
NCT02195518 | Hepatitis B, Chronic | Phase 4 | Completed | - | China, Guangdong ... more >> GSK Investigational Site Guangzhou, Guangdong, China, 510060 GSK Investigational Site Guangzhou, Guangdong, China, 510150 China, Jilin GSK Investigational Site Changchun, Jilin, China China, Sichuan GSK Investigational Site Chengdu, Sichuan, China, 610041 China, Zhejiang GSK Investigational Site Hangzhou, Zhejiang, China, 310000 China GSK Investigational Site Beijing, China, 100034 GSK Investigational Site Beijing, China, 100044 GSK Investigational Site Beijing, China, 100050 GSK Investigational Site Beijing, China, 100054 GSK Investigational Site Shanghai, China, 200025 GSK Investigational Site Shanghai, China, 200040 GSK Investigational Site Zhengzhou, China Collapse << |
NCT01455116 | Septic Shock | Phase 2 Phase 3 | Terminated(Futility) | - | United States, Ohio ... more >> Cleveland Clinic - Outcomes Research Cleveland, Ohio, United States, 44195 Denmark Bispebjerg Hospital Copenhagen, Capital Region, Denmark, 2400 Jens Ulrik S. Jensen Copenhagen, Capital Region, Denmark, DK-2200 Gentofte Hospital Gentofte, Capital Region, Denmark, 2900 Herlev Hospital Herlev, Capital Region, Denmark, 2730 Nordsjællands Hospital, Hillerød Hillerød, Capital Region, Denmark, 3400 Aarhus University Hospital, Skejby Aarhus, Jutland, Denmark, 8200 Horsens Hospital Horsens, Jutland, Denmark Køge Hospital Køge, Region Sealand, Denmark, 4600 Roskilde Hospital Roskilde, Region Sealand, Denmark, 4000 Netherlands Academic Medical Center Amsterdam, Netherlands Collapse << |
NCT00117676 | Chronic Hepatitis B | Phase 3 | Completed | - | - |
NCT03180619 | Chronic Hepatitis B | Phase 2 | Active, not recruiting | February 2021 | - |
NCT00001610 | - | - | Completed | - | United States, Maryland ... more >> National Eye Institute (NEI) Bethesda, Maryland, United States, 20892 Collapse << |
NCT00117676 | - | - | Completed | - | - |
NCT02979613 | Chronic Hepatitis B | Phase 3 | Active, not recruiting | February 2020 | - |
NCT01356901 | - | - | Completed | - | Germany ... more >> Local Institution Herne, Germany, 44623 Collapse << |
NCT00120770 | HIV Infections ... more >> Gonorrhea Chlamydia Infections Collapse << | Phase 3 | Terminated(The study was halte... more >>d in January 2007 due to safety concerns.) Collapse << | - | Nigeria ... more >> Lagos University, College of Medicine, Center 10151 Lagos, Nigeria University of Port Harcourt Teaching Hospital, Center 10152 Port Harcourt, Nigeria Collapse << |
NCT00116805 | Chronic Hepatitis B | Phase 3 | Completed | - | - |
NCT00357071 | - | - | Completed | - | United States, Maryland ... more >> National Institutes of Health Clinical Center, 9000 Rockville Pike Bethesda, Maryland, United States, 20892 Collapse << |
NCT00122486 | HIV Infections | Phase 2 | Completed | - | Cameroon ... more >> Care and Health Program Douala, Cameroon Ghana Virtual Access Tema, Ghana Nigeria University of College Hospital Ibadan, Nigeria Collapse << |
NCT00116805 | - | - | Completed | - | - |
NCT00570440 | Pregnancy Prevention | Phase 4 | Completed | - | Dominican Republic ... more >> PROFAMILIA - Santo Domingo, Dominican Republic Ens. Luperon, Santo Domingo, Dominican Republic Nicaragua PROFAMILIA - Managua, Nicaragua Managua, Nicaragua Collapse << |
NCT00122512 | HIV Infections | Phase 2 | Terminated | - | Malawi ... more >> UNC Project, Kamuzu Central Hospital Lilongwe, Malawi Collapse << |
NCT01334190 | - | - | Completed | - | Kenya ... more >> FHI Nairobi, Kenya Collapse << |
NCT01452503 | Contraception | Not Applicable | Completed | - | South Africa ... more >> Commercial City Clinic Department of Health Durban, South Africa, 4001 Collapse << |
NCT01226433 | - | - | Completed | - | Kenya ... more >> 5 Community Outreach Events Various, Rift Valley & Central, Kenya Collapse << |
NCT01594632 | Contraception | Not Applicable | Completed | - | Dominican Republic ... more >> Profamilia Santo Domingo, Dominican Republic Collapse << |
NCT01667276 | - | - | Completed | - | Senegal ... more >> Ministry of Health Clinics All Cities Where There Is A Clinic, Senegal Uganda Ministry of Health Clinics, Uganda All Cities Where There Is A Clinic, Uganda Collapse << |
NCT01721798 | HIV | Not Applicable | Completed | - | South Africa ... more >> University of Cape Town Cape Town, Western Cape Province, South Africa, 7701 Collapse << |
NCT01808352 | HIV | Phase 4 | Completed | - | United States, California ... more >> UCLA Vine Street Clinic Los Angeles, California, United States, 90095 United States, District of Columbia George Washington University CRS Washington, District of Columbia, United States, 20007 United States, North Carolina UNC CRS Chapel Hill, North Carolina, United States, 27514 Collapse << |
NCT01463254 | - | - | Completed | - | Pakistan ... more >> Marie Stopes Society clinics Pakistan, Pakistan Collapse << |
NCT00829114 | HIV/AIDS HIV ... more >>Infections Collapse << | Phase 4 | Completed | - | South Africa ... more >> , RHRU National Office, University of Witwatersand Esselent St. Hillbrow, Johannesburg, South Africa, 2001 Uganda Makerere University Medical School, Mulago Hospital, Department of Obstetrics and Gynecology Kampala, Uganda Collapse << |
NCT00423891 | Hepatitis B, Chronic | Phase 1 Phase 2 | Completed | - | - |
NCT00941876 | HIV Infection ... more >> HIV Infections Collapse << | Not Applicable | Completed | - | Tanzania ... more >> Muhimbili University of Health and Allied Services Dar es Salaam, Tanzania Collapse << |
NCT00423891 | - | - | Completed | - | - |
NCT00316719 | Chronic Hepatitis B | Phase 3 | Completed | - | - |
NCT00316719 | - | - | Completed | - | - |
NCT01903889 | HIV | Not Applicable | Completed | - | Uganda ... more >> Bukinda Health Center Kabale, Uganda Kamkira Health Center Kabale, Uganda Kamwezi Health Center Kabale, Uganda Maziba Health Center Kabale, Uganda Mparo Health Center Kabale, Uganda Muko Health Center Kabale, Uganda Rubaya Health Center Kabale, Uganda Collapse << |
NCT01266005 | Chronic Hepatitis B | Phase 4 | Terminated | - | Korea, Republic of ... more >> 9 Sites Seoul, Korea, Republic of Collapse << |
NCT02762669 | Postpartum Hemorrhage | Not Applicable | Recruiting | December 2018 | Canada, Ontario ... more >> Mount Sinai Hospital Recruiting Toronto, Ontario, Canada, M5G1X5 Contact: Mrinalini Balki, MD 416-586-4800 ext 5270 mrinalini.balki@uhn.ca Sub-Investigator: John Kingdom, MD Sub-Investigator: Alice Luca, MSc Sub-Investigator: Dora Baczyk, MD Collapse << |
NCT02982837 | Hepatitis B | Phase 4 | Recruiting | May 2019 | Saudi Arabia ... more >> King Abdulaziz Medical City Recruiting Jeddah, Saudi Arabia, 22384 Contact: Faisal Sanai, MD +966 12 2266666 ext 24828 sanaifa@ngha.med.sa King Abdulaziz Hospital Recruiting Jeddah, Saudi Arabia, 31982 Contact: Elsadig Ahmed Nour Mohamed, MD mohamedel1@ngha.med.sa King Abdulaziz Medical City Recruiting Riyadh, Saudi Arabia, 11426 Contact: Abduljaleel Alwan, MD 801 111 ext 11622 alwana@ngha.med.sa Contact: Ansif Majeed, MBA (011)429-9999 ext 94436 pallathmajeedan@ngha.med.sa Collapse << |
NCT01586364 | - | - | Completed | - | - |
NCT00494429 | Premature Neonates | Phase 2 | Completed | - | United States, District of Col... more >>umbia Children's National Medical Center Washington, District of Columbia, United States, 20010 Collapse << |
NCT01586364 | Atrophy Vagin... more >>al Diseases Collapse << | Phase 3 | Completed | - | - |
NCT02727972 | Major Depressive Disorder ... more >> Post-Traumatic Stress Disorder Bipolar Disorder Collapse << | Not Applicable | Recruiting | August 2020 | United States, Connecticut ... more >> PET Center Recruiting New Haven, Connecticut, United States, 06519 Contact: Sarah O, MA 203-737-7066 Principal Investigator: Irina Esterlis, PhD Collapse << |
NCT01264107 | - | - | Completed | - | Korea, Republic of ... more >> Soon Koo Baik Wonju, Kangwon-do 162 Ilsan-dong, Wonju, Kangwon-do, Korea, Republic of, 220-701 Collapse << |
NCT01960075 | Benzodiazepine Refractory Stat... more >>us Epilepticus Collapse << | Phase 3 | Recruiting | July 2020 | - |
NCT02486614 | - | - | Recruiting | October 2017 | United Kingdom ... more >> Guy's & St Thomas Hospital Recruiting London, United Kingdom, SE1 7EH Contact: Marlies Ostermann, PhD Marlies.Ostermann@gstt.nhs.uk Sub-Investigator: Richard Fisher Collapse << |
NCT02606643 | - | - | Completed | - | - |
NCT01464281 | Chronic Hepatitis B | Not Applicable | Unknown | December 2016 | China, Chongqing ... more >> The 2nd affiliated Hospital of Chongqing Medical University Chongqing, Chongqing, China, 400010 Collapse << |
NCT02606643 | Cervical Dilation | Not Applicable | Completed | - | United States, Missouri ... more >> St. Mary's Health Center Saint Louis, Missouri, United States, 63117 Collapse << |
NCT01745822 | Hepatitis B Chronic Infection ... more >> Pregnancy Collapse << | Phase 3 | Active, not recruiting | October 2018 | Thailand ... more >> Prapokklao Hospital Chantha Buri, Chanta Buri, Thailand, 22000 Mae Chan Hospital Mae Chan, Chiangrai, Thailand, 57110 Banglamung Hospital Bang Lamung, Chon Buri, Thailand, 20150 Maharat Nakhon Ratchasima Hospital Nakhon Ratchasima, Nakhon Ratchasrima, Thailand, 30000 Chiang Kham Hospital Chiang Kham, Phayao, Thailand, 56110 Bhumibol Adulyadej Hospital Bangkok, Thailand, 10220 Nopparat Rajathanee Hospital Bangkok, Thailand, 10230 Health Promotion Center Region 10 Chiang Mai, Thailand, 50100 Nakornping Hospital Chiang Mai, Thailand, 50180 Chiangrai Prachanukroh Hospital Chiang Rai, Thailand, 57000 Chonburi Regional Hospital Chon Buri, Thailand, 20000 Khon Kaen Hospital Khon Kaen, Thailand, 40000 Lampang Hospital Lampang, Thailand, 52000 Lamphun Hospital Lamphun, Thailand, 51000 Phayao Provincial Hospital Phayao, Thailand, 56000 Samutprakarn Hospital Samut Prakan, Thailand, 10280 Samutsakhon Hospital Samut Sakhon, Thailand, 74000 Collapse << |
NCT03459287 | Anemia | Phase 3 | Not yet recruiting | July 31, 2020 | - |
NCT02444611 | Innate Immune Response | Not Applicable | Completed | - | Australia, Victoria ... more >> Mercy Hospital for Women Heidelberg, Victoria, Australia, 3084 Collapse << |
NCT00307021 | Malaria | Phase 2 | Completed | - | Gabon ... more >> GSK Investigational Site Lambaréné, Gabon Collapse << |
NCT01554904 | Primary Snoring ... more >> Sleep Apnea Collapse << | Not Applicable | Completed | - | United States, Florida ... more >> Shands Sleep Disorders Center Gainesville, Florida, United States, 32606 Collapse << |
NCT01554904 | - | - | Completed | - | - |
NCT01473446 | Postoperative Complications | Not Applicable | Terminated(High exclusion rate... more >>) Collapse << | - | Finland ... more >> Oulu University Hospital, Department of Anesthesia and Intensive Care Oulu, Finland, 90029 Norway Haukeland University Hospital Bergen, Norway, 5021 Stavanger Universityhospital, Division for medical service, anesthesia and intensive care Stavanger, Norway, 4011 Collapse << |
NCT03645044 | - | - | Recruiting | December 2022 | India ... more >> YRGCare Not yet recruiting Chennai, India Contact: Nagalingeswaran Kumarasamy, MD +91 44 71026610 info@yrgcare.org Malaysia Clinical Investigation Centre (CIC), University of Malaya, Infectious Diseases Directorate Not yet recruiting Kuala Lumpur, Malaysia Contact: Iskandar Azwa, MD +603-7949-3641 iskandar.azwa@gmail.com Thailand HIV-NAT/Thai Red Cross AIDS Research Centre Recruiting Bangkok, Thailand Contact: Anchalee Avihingsanon, MD, PhD +66 (0) 2652 3040 anchalee.a@hivnat.org) Collapse << |
NCT02466646 | Aggressive Periodontitis | Phase 4 | Completed | - | - |
NCT02218515 | Periodontal Bone Loss ... more >> Chronic Periodontitis Collapse << | Phase 4 | Completed | - | Turkey ... more >> Marmara University Faculty of Dentistry, Department of Periodontology İstanbul, Şişli/Nişantaşı, Turkey, 34365 Collapse << |
NCT03468946 | Healthy | Not Applicable | Completed | - | - |
NCT00449722 | Ulcerative Colitis | Phase 3 | Completed | - | Germany ... more >> Evangelisches Krankenhaus Kalk Cologne, Germany, 51103 Collapse << |
NCT00746447 | Colitis, Ulcerative ... more >> Recurrence Collapse << | Phase 3 | Completed | - | Germany ... more >> Evangelisches Krankenhaus Kalk, Medical Dept. Cologne, Germany, 51103 Collapse << |
NCT01038739 | Diverticulitis | Phase 3 | Terminated(Stopped due to futi... more >>lity.) Collapse << | - | United States, Florida ... more >> United Medical Research New Smyrna Beach, Florida, United States, 32168 Collapse << |
NCT03287999 | - | - | Not yet recruiting | October 2, 2019 | United Kingdom ... more >> Royal Free Hospital Not yet recruiting London, United Kingdom Contact: Thomas Roberts Principal Investigator: Pratima Chowdary Collapse << |
NCT02600117 | Hepatitis B, Chronic | Phase 3 | Enrolling by invitation | December 2019 | Canada, Ontario ... more >> University Health Network - Toronto General Hospital Toronto, Ontario, Canada, M5G 2C4 Collapse << |
NCT03507036 | Skin Laxity | Not Applicable | Active, not recruiting | December 1, 2019 | United States, Texas ... more >> University of Texas Southwestern Medical Center Dallas, Texas, United States, 75390 Collapse << |
NCT02063815 | Caries Prevention ... more >> Fissure Sealant Fluoride Concentration Glass Ionomer Cement Resin Collapse << | Not Applicable | Completed | - | - |
NCT00695643 | Diverticulitis | Phase 3 | Terminated | - | Germany ... more >> Evang. Krankenhaus Kalk, Medical department Cologne, Germany, 51103 Collapse << |
NCT01199601 | Viral Hepatitis B ... more >> Contraception Breast Feeding, Exclusive Effects of; Lack of Care of Infants Collapse << | Not Applicable | Completed | - | Afghanistan ... more >> Maternity Hospitals Kabul, Afghanistan Collapse << |
NCT01199601 | - | - | Completed | - | - |
NCT02138136 | Constipation - Functional | Phase 3 | Completed | - | - |
NCT03621917 | - | - | Completed | - | Turkey ... more >> Dokuz Eylul University Hospital Izmir, Narlidere, Turkey, 35320 Collapse << |
NCT02042183 | Constipation - Functional | Phase 3 | Completed | - | - |
NCT01119703 | - | - | Completed | - | - |
NCT01861613 | Hepatitis B I... more >>mmune Response Seroprevalence Collapse << | Phase 4 | Completed | - | China, Guangxi ... more >> Guangxi Centers for Disease Control and Prevention Nanning, Guangxi, China Collapse << |
NCT01119703 | - | - | Completed | - | - |
NCT03217006 | Coronary Artery Disease ... more >> Heart Diseases Collapse << | Not Applicable | Recruiting | March 31, 2022 | United States, New York ... more >> Weil Cornell Medical College Department of Cardiothoracic Surgery Recruiting New York, New York, United States, 10065 Contact: Mario F Gaudino, MD 212-746-1815 mfg9004@med.cornell.edu Contact: Renee Aviv, RN 212-746-5194 rek9015@med.cornell.edu Collapse << |
NCT03734965 | Cervical Disorder | Not Applicable | Recruiting | December 1, 2020 | Turkey ... more >> Trakya University Recruiting Edirne, Centrum, Turkey, 22030 Contact: Fatih Sağ, resident +90-284-235-76-41 sag.fatih@gmail.com Contact: Sevtap Hekimoğlu Şahin, Professor sevtaphekimoglu@mynet.com Collapse << |
NCT01627262 | Colonic Diverticulosis | Phase 2 | Completed | - | Germany ... more >> Ev. Krankenhaus Kalk, University of Cologne Köln, Germany, 51103 Collapse << |
NCT02044068 | - | - | Completed | - | France ... more >> Hopital Lariboisiere Paris, France, 75475 Collapse << |
NCT02058134 | Coronary Artery Disease ... more >> Aortic Stenosis Aortic Insufficiency Mitral Insufficiency Aortic Aneurysm Collapse << | Not Applicable | Terminated(Due to other trials... more >> in the department) Collapse << | - | Denmark ... more >> Department of Cardiothoracic Surgery, Rigshospitalet Copenhagen, København Ø, Denmark, 2100 Collapse << |
NCT02901600 | - | - | Completed | - | - |
NCT01240473 | Visceral Leishmaniasis | Not Applicable | Completed | - | Bangladesh ... more >> Community-based Medical College, Bangladesh (CBMC,B) Mymensingh, Dhaka, Bangladesh Collapse << |
NCT02051413 | Major Depressive Disorder ... more >> Major Depressive Episode Collapse << | Phase 4 | Unknown | February 2017 | France ... more >> CHU de Bicetre Recruiting Le Kremlin Bicetre, France, 94275 Principal Investigator: Emmanuelle Corruble, MD, PhD Collapse << |
NCT00990574 | Hypotension H... more >>eadache Collapse << | Not Applicable | Withdrawn(device not found to ... more >>be adequate) Collapse << | - | United States, California ... more >> Stanford University School of Medicine Stanford, California, United States, 94305 Collapse << |
NCT01264094 | Chronic Hepatitis B | Phase 4 | Terminated(Enrollment) | - | Korea, Republic of ... more >> Gangnam Severance Hospital Seoul, Korea, Republic of Collapse << |
NCT03517930 | Clinical Pharmacology | Phase 1 | Completed | - | United States, New Jersey ... more >> Frontage Clinical Services Secaucus, New Jersey, United States, 07094 Collapse << |
NCT03517943 | Clinical Pharmacology | Phase 1 | Completed | - | United States, New Jersey ... more >> Frontage Clinical Services Secaucus, New Jersey, United States, 07094 Collapse << |
NCT01820702 | Bone Diseases, Metabolic ... more >> Acid-Base Imbalance Muscular Atrophy Sprains and Strains Protein Metabolism Body Weight Changes Cardiovascular Abnormalities Collapse << | Not Applicable | Completed | - | Germany ... more >> German Aerospace Center (DLR) Cologne, Germany, 51147 Collapse << |
NCT00503633 | - | - | Completed | - | United States, California ... more >> University of California, San Francisco San Francisco, California, United States, 94143 Collapse << |
NCT02229916 | - | - | Recruiting | September 2029 | Switzerland ... more >> Kantonsspital St.Gallen; Onkologie/Haematologie Recruiting St.Gallen, Switzerland, 9007 Contact: Christian Rothermundt, Dr. med. +41 71 494 11 11 christian.rothermundt@kssg.ch Principal Investigator: Christian Rothermundt, Dr. med. Collapse << |
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