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CAS No.: 1450881-55-6

SAR-20347 Catalog No. CSN24499

Synonyms: SAR-20347

SAR-20347 is a TYK2 and JAK inhibitor with IC50 values of 0.6, 23, 26 and 41nM for TYK2, JAK1, JAK2 and JAK3, respectively.

规格	价格	促销价格	库存	数量

400-920-2911

sales@csnpharm.cn

tech@csnpharm.cn

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400-920-2911

sales@csnpharm.cn

tech@csnpharm.cn

纯度 & 质量文件批次:

靶点选择性

生物活性

实验方案

技术信息

生物活性

描述SAR-20347 is a selective JAK1 and TYK2 inhibitor with IC50 values of 59nM and 13nM, respectively, in TR-FRET analysis. SAR-20347 at 1nM-10μM dose-dependently inhibited JAK1- and/or TYK2-dependent signaling from the IL-12/IL-23, IL-22, and IFN-α receptors, in cellular assays. IL-22 (10ng/ml, 15min)-induced up-regulation of pSTAT3 level was potently inhibited by pretreatment with SAR-20347 at 1-10μM for 20min in HT-29 cells. Oral administration of SAR-20347 at 50mg/kg, 30 min prior to injection of 10 mg IL-22 (i.p.), significantly reduced IL-22–dependent serum amyloid A in mice. In an imiquimod-induced psoriasis model, administration of SAR-20347 at dose of 50mg/kg (oral gavage 30 min prior to application of 62.5 mg 5% imiquimod cream) led to a striking decrease in disease pathology, including reduced activation of keratinocytes and pro-inflammatory cytokine levels compared with both TYK2 mutant mice and wild-type controls.

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.2480 mL
- 11.2399 mL
- 22.4798 mL
- 5 mM
- 0.4496 mL
- 2.2480 mL
- 4.4960 mL
- 10 mM
- 0.2248 mL
- 1.1240 mL
- 2.2480 mL

技术信息

CAS号

1450881-55-6

储存条件

粉末: Keep in dark place,Inert atmosphere,Room temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C21H18ClFN4O4

运输

蓝冰

分子量

444.84

别名

SAR-20347

溶解度

DMSO	89.0 mg/mL (200.1 mM)
Water	Insoluble
Ethanol	Insoluble

动物实验配方

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