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CAS No.: 135897-06-2
Synonyms: Sb 218078
Inhibitor of checkpoint kinase 1 (Chk1) that displays selectivity over other protein kinases (IC50 values are 15, 250 and 1000 nM for Chk1, cdc2 and PKC respectively). Abrogates G2 cell cycle arrest caused by γ-irradiation and topoisomerase I inhibition. Potentiates cytotoxicity of DNA-damaging drugs, enhancing the efficacy of some chemotherapeutics.
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实验方案
技术信息
CAS号 | 135897-06-2 | 储存条件 |
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分子式 | C24H15N3O3 | 运输 | 蓝冰 | |
分子量 | 393.39 | 别名 | Sb 218078 |
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