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CAS No.: 694433-59-5
Synonyms: SB-505124
SB505124 is an inhibitor of TGFβ receptor for ALK4 (IC50 = 129 nM) and ALK5 (IC50 = 47 nM). It can also inhibit ALK7.
生物活性
实验方案
技术信息
CAS号 | 694433-59-5 | 储存条件 |
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分子式 | C20H21N3O2 | 运输 | 蓝冰 | |||||||||||
分子量 | 335.40 | 别名 | SB-505124 | |||||||||||
溶解度 |
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动物实验配方 |
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Cell Lines | Concentration | Assay Type | Time | Activity Description | Data Sources |
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human HaCaT cells | - | Function assay | - | Inhibition of ALK5 in human HaCaT cells assessed as inhibition of TGFbeta1-induced luciferase activity after 24 hrs by luciferase reporter gene assay, IC50=43.8 nM | 24786585 |
mouse 4T1 cells | - | Function assay | - | Inhibition of ALK5 in mouse 4T1 cells assessed as inhibition of TGFbeta1-induced luciferase activity after 24 hrs by luciferase reporter gene assay, IC50=76.6 nM | 24786585 |
mouse NMuMG cells | 0.1-0.5 μM | Function assay | 1 h | Inhibition of ALK5 activity in mouse NMuMG cells assessed as TGFbeta-induced phosphorylation of Smad2 at 0.1 to 0.5 uM after 1 hr by Western blot analysis | 23047226 |
Sf9 insect cells | - | Function assay | - | Inhibition of human recombinant GST-fused ALK5 expressed in Sf9 insect cells using casein as substrate by proprietary radioisotopic protein kinase assay, IC50=34.9 nM | 26483198 |
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