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CAS No.: 371980-98-2
Synonyms: (5S,7S)-7-((4-(2,6-dichlorophenyl)piperidin-1-yl)methyl)-1-methyl-6,7,8,9-tetrahydro-5h-benzo[7]annulen-5-ol hcl
SB-612111 is a novel and potent human opiate receptor-like orphan receptor (ORL-1) antagonist with a high affinity for hORL-1 (Ki=0.33 nM). SB-612111 exhibits selectivity for μ-, κ- and δ-receptors with Ki values of 57.6 nM, 160.5 nM and 2109 nM, respecticely. SB-612111 effectively antagonizes the pronociceptive action of Nociceptin (HY-P0183) in an acute pain model[1].
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CAS号 | 371980-98-2 | 储存条件 |
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分子式 | C24H30Cl3NO | 运输 | 蓝冰 | |
分子量 | 454.86 | 别名 | (5S,7S)-7-((4-(2,6-dichlorophenyl)piperidin-1-yl)methyl)-1-methyl-6,7,8,9-tetrahydro-5h-benzo[7]annulen-5-ol hcl |
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