CAS No.: 1423715-37-0
Seclidemstat Catalog No. CSN21313
Synonyms: SP-2577
Seclidemstat is a potent LSD1 inhibitor, with a mean IC50 of 127 nM.
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纯度 & 质量文件
批次:
靶点选择性
生物活性
- 描述
- 临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点 NCT03600649 Ewing Sarcoma Phase 1 Recruiting August 2020 United States, California ... more >> Childrens Hospital Los Angeles Recruiting Los Angeles, California, United States, 90027 Contact: Leo Mascarhenas, MD Contact: Magnolia Manzano United States, Florida Johns Hopkins All Children's Hospital Not yet recruiting Saint Petersburg, Florida, United States, 33701 Contact: Jessica Crimella Principal Investigator: Jonathan Metts, MD Moffitt Cancer Center Recruiting Tampa, Florida, United States, 33612 Contact: Tiffany Smith, MS, CRC Principal Investigator: Damon Reed, MD United States, Massachusetts Dana-Farber Cancer Institute Recruiting Boston, Massachusetts, United States, 02215 Contact: Morgan Krush Principal Investigator: Steven Dubois, MD United States, Texas MD Anderson Cancer Center Recruiting Houston, Texas, United States, 77030 Contact: Douglas Harrison, MD Contact: Sherry Melton Collapse << - 参考文献
- [1] Hosseini A, Minucci S. A comprehensive review of lysine-specific demethylase 1 and its roles in cancer. Epigenomics. 2017;9(8):1123-1142.
- [2] Hariprasad V, et al. Substituted benzohydrazide analogs as histone demethylase inhibitors. WO 2017004519 A1.
- [3] A Phase I dose escalation and expansion study of seclidemstat (SP-2577) a first-in class reversible LSD1 inhibitor for patients with relapsed or refractory Ewing sarcoma.
实验方案
- 计算器
- 储存液制备
技术信息
| CAS号 | 1423715-37-0 | 储存条件 |
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| 分子式 | C20H23ClN4O4S | 运输 | 蓝冰 | |||||
| 分子量 | 450.94 | 别名 | SP-2577 | |||||
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动物实验配方 |
