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CAS No.: 1020149-73-8
Synonyms: DNA Methyltransferase Inhibitor II
SGI-1027 is a potent and selective inhibitor of DNA methyltransferase (DNMT) with IC50 of 6, 8, 7.5 μM for DNMT1, DNMT3A, and DNMT3B, respectively.
生物活性
靶点 | DNA Methyltransferase 1 IC50:6μM | DNA Methyltransferase 3B IC50:7.5μM | DNA Methyltransferase 3A IC50:8μM |
实验方案
技术信息
CAS号 | 1020149-73-8 | 储存条件 |
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分子式 | C27H23N7O | 运输 | 蓝冰 | |||||||
分子量 | 461.52 | 别名 | DNA Methyltransferase Inhibitor II | |||||||
溶解度 |
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动物实验配方 |
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Cell Lines | Concentration | Assay Type | Time | Activity Description | Data Sources |
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human HCT116 cells | - | Cytotoxicity assay | - | Cytotoxicity against human HCT116 cells assessed as viability, TD50=25 μM | 23639684 |
human KARPAS299 cells | - | Proliferation assay | 2-4 days | Antiproliferative activity against human KARPAS299 cells after 2 to 4 days by ATPlite 1step luminescence assay, EC50=1.8 μM | 26220519 |
human KG1 cells | - | Proliferation assay | 2-4 days | Antiproliferative activity against human KG1 cells after 2 to 4 days by ATPlite 1step luminescence assay, EC50=4.4 μM | 26220519 |
human MDA-MB-231 cells | - | Cytotoxicity assay | 48 h | Cytotoxicity against human MDA-MB-231 cells after 48 hrs by trypan blue exclusion assay, IC50=4.8 μM | 24387159 |
human PBMC | - | Cytotoxicity assay | 48 h | Cytotoxicity against human PBMC after 48 hrs by trypan blue exclusion assay, IC50=23.8 μM | 24387159 |
human PC3 cells | - | Cytotoxicity assay | 48 h | Cytotoxicity against human PC3 cells after 48 hrs by trypan blue exclusion assay, IC50=6.5 μM | 24387159 |
human Raji cells | - | Cytotoxicity assay | 48 h | Cytotoxicity against human Raji cells after 48 hrs by trypan blue exclusion assay, IC50=9.1 μM | 24387159 |
human U937 cells | - | Cytotoxicity assay | 48 h | Cytotoxicity against human U937 cells after 48 hrs by trypan blue exclusion assay, IC50=1.7 μM | 24387159 |
靶点 | Description | IC50 |
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DNA Methyltransferase 1 | IC50:6μM | |
DNA Methyltransferase 3B | IC50:7.5μM | |
DNA Methyltransferase 3A | IC50:8μM |
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