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CAS No.: 2458219-65-1
SHP2-D26 is a first, potent, and effective PROTAC degrader of SHP2 protein. SHP2-D26 achieves DC50 values of 6.0 and 2.6 nM in esophageal cancer KYSE520 and acute myeloid leukemia MV4;11 cells, respectively, and is capable of reducing SHP2 protein levels by >95% in cancer cells. SHP2-D26 is >30-times more potent in inhibition of phosphorylation of extracellular signal-regulated kinase (ERK) and of cell growth than SHP099, a potent SHP2 inhibitor, in KYSE520 and MV4;11 cancer cell lines.
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技术信息
CAS号 | 2458219-65-1 | 储存条件 |
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分子式 | C56H79ClN12O6S2 | 运输 | 蓝冰 | |
分子量 | 1115.89 | 别名 |
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