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CAS No.: 2374313-54-7

SIS17 Catalog No. CSN24467

SIS17 is a specific HDAC11 inhibitor with IC50 value of 0.83μM for inhibition of the demyristoylation HDAC11 substrate, serine hydroxymethyl transferase 2.

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技术信息

生物活性

描述Histone deacetylases (HDACs) are a class of zinc-dependent amide hydrolases with important biological functions. They catalyze the deacetylation of numerous substrate proteins, including histones, transcription factors, and signaling proteins, and thus regulate various biological processes. SIS17, a HDAC 11 inhibitor with an IC₅₀ value of 0.83 μM, inhibits the demyristoylation of a known HDAC11 substrate, serine hydroxymethyl transferase 2, without inhibiting other HDACs. Using a myristoyl-SHMT2 peptide as the substrate, SIS17 could still inhibit HDAC11 with IC₅₀ value of 270 nM. SIS17 increased the fatty acylation level of SHMT2 significantly in MCF7 cells down to 12.5 μM, demonstrating that it is cell permeable and can inhibit HDAC11 in living cells^[1].
参考文献

[1] Son SI, Cao J, Zhu CL, Miller SP, Lin H. Activity-Guided Design of HDAC11-Specific Inhibitors. ACS Chem Biol. 2019;14(7):1393-1397

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.7277 mL
- 13.6387 mL
- 27.2774 mL
- 5 mM
- 0.5455 mL
- 2.7277 mL
- 5.4555 mL
- 10 mM
- 0.2728 mL
- 1.3639 mL
- 2.7277 mL

技术信息

CAS号

2374313-54-7

储存条件

粉末: Keep in dark place,Sealed in dry,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C21H38N2OS

运输

蓝冰

分子量

366.60

别名

溶解度

DMSO	insoluble
Water	insoluble

动物实验配方

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