CAS No.: 77307-50-7
SL 0101-1 Catalog No. CSN20281
Synonyms: SL0101
SL0101 is a selective inhibitor of ribosomal S6 kinase (RSK) (IC50 = 89 nM for RSK2) which does not inhibit upstream kinases such as MEK, Raf and PKC. SL0101 Inhibits the growth of MCF-7 human breast cancer cells with no effect on the normal breast cell line.
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纯度 & 质量文件
批次:
靶点选择性
生物活性
- 描述
- 参考文献
- [1] Li M, Li Y, Ludwik KA, et al. Stereoselective Synthesis and Evaluation of C6″-Substituted 5a-Carbasugar Analogues of SL0101 as Inhibitors of RSK1/2. Org Lett. 2017 May 5;19(9):2410-2413.
- [2] Ludwik KA, Campbell JP, et al. Development of a RSK Inhibitor as a Novel Therapy for Triple-Negative Breast Cancer. Mol Cancer Ther. 2016 Nov;15(11):2598-2608.
实验方案
- 计算器
- 储存液制备
技术信息
| CAS号 | 77307-50-7 | 储存条件 |
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| 分子式 | C25H24O12 | 运输 | 蓝冰 | |
| 分子量 | 516.45 | 别名 | SL0101 |
