|3-氨基-3-((4-氨基苯基)硫基)-2-(2-(三氟甲基)苯基)丙烯腈|CsnPharm

CAS No.: 305350-87-2

SL327 Catalog No. CSN11936

Synonyms: SL327

SL327 is a cell-permeable vinylogous cyanamide that acts as a selective inhibitor of MEK-1 and MEK-2 (IC50 = 0.18 and 0.22 μM respectively).

规格	价格	促销价格	库存	数量

400-920-2911

sales@csnpharm.cn

tech@csnpharm.cn

加入购物车大规格询价

加入收藏

产品咨询

400-920-2911

sales@csnpharm.cn

tech@csnpharm.cn

纯度 & 质量文件批次:

靶点选择性

生物活性

实验方案

技术信息

生物活性

描述Mitogen-activated protein kinases/extracellular signal-regulated kinase (MAPK/ERK) pathway, also known as MEK pathway, is reported to be associated with the cell proliferation, differentiation, migration, senescence and apoptosis^[3]. SL327 inhibits MEK1 and MEK2, with IC₅₀ values of 0.18 μM and 0.22 μM, respectively^[4]. In vivo, the study showed that the combination of SL327 with sunitinib malate induced significant additive suppression of doxorubicin-resistant anaplastic thyroid carcinoma (ATC) tumor growth^[4]. SL327 attenuates phosphorylated MAPK levels in a dose-dependent manner in mice. Administration of 10, 30, or 50 mg/kg SL327 significantly attenuates p42 phospho-MAPK levels (F=20.90, P<0.0001; 10 mg/kg SL327 vs. vehicle, P<0.05, and 30 and 50 mg/kg SL327 vs. vehicle, P<0.001). Injection with 30 or 50 mg/kg SL327 also significantly reduces p44 phospho-MAPK levels (F=5.627, P<0.005; 30 mg/kg vs. vehicle, P<0.05, and 50 mg/kg SL327 vs. vehicle, P<0.01)^[5].
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.9820 mL
- 14.9099 mL
- 29.8199 mL
- 5 mM
- 0.5964 mL
- 2.9820 mL
- 5.9640 mL
- 10 mM
- 0.2982 mL
- 1.4910 mL
- 2.9820 mL

技术信息

CAS号

305350-87-2

储存条件

粉末: Keep in dark place,Inert atmosphere,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C16H12F3N3S

运输

蓝冰

分子量

335.35

别名

SL327

溶解度

DMSO	67.0 mg/mL (199.8 mM)
Water	Insoluble
Ethanol	7.0 mg/mL (20.9 mM)

动物实验配方

2% DMSO+30% PEG 300+5% Tween 80+water

5 mg/mL

大规格询价

号为必填项

姓名: 邮箱: 手机号:

留言:

提交

SL327 Catalog No. CSN11936

靶点选择性

请登录您的专属账户

确认信息