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CAS No.: 152-95-4

Sophoricoside/槐角苷 Catalog No. CSN19423

Synonyms: Genistein 4′-O-glucoside;槐角苷

Sophoricoside is an isoflavone glycoside present in fruits of sophora japonica L. with anti-inflammatory and immunosuppressive effects.

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技术信息

生物活性

描述Sophoricoside is an isoflavone glycoside present in fruits of sophora japonica L. with anti-inflammatory and immunosuppressive effects. Sophoricoside (50 μM) significantly inhibits the PMACI-induced histamine release. The inhibition rate reaches up to 30.24%. The maximal rates of TNF-α, IL-8 and IL-6 inhibition by Sophoricoside (50 μM) are approximately 31.42%, 43.43% and 34.24%, respectively. The rates of the levels of Rel/p65 inhibition in nuclear by Sophoricoside (50 μM) is approximately 50.14%. Results show that the enhanced caspase-1 activity induced by PMACI is significantly reduced by Sophoricoside in a dose-dependent manner^[3]. Sop (Sophoricoside) ameliorates cardiac hypertrophy by activating AMPK/mTORC1-mediated autophagy^[4].Sophoricoside protected against obesity and glucose tolerance, and inhibited lipid accumulation in the liver of high-fat diet-induced obesity (DIO) mice and methionine and choline-deficient diet-induced nonalcoholic steatohepatitis mice. Furthermore, sophoricoside inhibited malondialdehyde, and increased superoxide dismutase and glutathione in the liver of the mice. In HepG2 cells, pretreatment with sophoricoside rescued GSH concentration decrease induced by H2 O2 treatment^[5]. Sophoricoside improved allergic asthma by suppressing mast cell activation and CD4+ T cell differentiation^[6]. SOP (Sophoricoside) pretreatment significantly ameliorated LPS(lipopolysaccharides)-induced pathological damage, tissue permeability, neutrophil infiltration and the production of pro-inflammatory cytokines (TNF-α, IL-1β and IL-6) in a murine model of ALI(acute lung injury)^[7].
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.3128 mL
- 11.5640 mL
- 23.1279 mL
- 5 mM
- 0.4626 mL
- 2.3128 mL
- 4.6256 mL
- 10 mM
- 0.2313 mL
- 1.1564 mL
- 2.3128 mL

技术信息

CAS号

152-95-4

储存条件

粉末: Keep in dark place,Inert atmosphere,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C21H20O10

运输

蓝冰

分子量

432.38

别名

Genistein 4′-O-glucoside;槐角苷

溶解度

DMSO	53.0 mg/mL (122.6 mM)
Water	insoluble

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