2095432-55-4|SR-18292|CsnPharm

CAS No.: 2095432-55-4

SR-18292 Catalog No. CSN19255

Synonyms: N/A

SR-18292 is a potential molecule with inhibition of PGC-1α gluconeogenic activity for treating diabetes by reducing blood glucose, strongly increases hepatic insulin sensitivity and improving glucose homeostasis in dietary and genetic mouse models of T2D.

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400-920-2911

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技术信息

生物活性

描述Peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α) is a key transcriptional coactivator in energy homeostasis that regulates fat and glucose metabolism. SR-18292 selectively increased PGC-1α acetylation at a concentration of 20µM. Treatment of primary hepatocytes with 20µM SR-18292 significantly reduced the ability of glucagon to stimulate the expression of the Pck1 and G6pc genes. SR-18292 at 20µM also significantly suppressed gluconeogenic gene and protein expression induced by ectopic expression of PGC-1α. In a dietary mouse model of type II diabetes mellitus, i.p. injection of SR-18292 at a dose of 45mg/kg for 4 days significantly decreased fasting blood glucose levels and hepatic expression of Pck1 compared with vehicle-treated controls. SR-18292 at the same dosage also significantly enhanced glucose tolerance and insulin sensitivity both in DIO mice and Lep^ob/ob mice^[2].
参考文献

[1] Sharabi K, Lin H, et al. Selective Chemical Inhibition of PGC-1α Gluconeogenic Activity Ameliorates Type 2 Diabetes. Cell. 2017 Mar 23;169(1):148-160.e15.
[2] Sharabi K, Lin H, Tavares CDJ, et al. Selective Chemical Inhibition of PGC-1α Gluconeogenic Activity Ameliorates Type 2 Diabetes. Cell. 2017;169(1):148-160.e15.

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.7285 mL
- 13.6427 mL
- 27.2854 mL
- 5 mM
- 0.5457 mL
- 2.7285 mL
- 5.4571 mL
- 10 mM
- 0.2729 mL
- 1.3643 mL
- 2.7285 mL

技术信息

CAS号

2095432-55-4

储存条件

粉末: Inert atmosphere,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C23H30N2O2

运输

蓝冰

分子量

366.50

别名

N/A

溶解度

DMSO	550.0 mg/mL (1500.7 mM) warming
Water	insoluble

动物实验配方

IP	2% DMSO+2% Tween80+40% PEG300+water	5 mg/mL	clear
PO	0.5% CMC-Na	31 mg/mL	suspension

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