CAS No.: 150375-75-0
SR 49059 Catalog No. CSN20586
Synonyms: Relcovaptan
SR49059 is a potent and selective non-peptide vasopressin V1A receptor antagonist which is devoid of agonist activity. SR49059 displays high affinity and efficacy at both rat (Ki = 1.6 nM) and human (Ki = 1.1 - 6.3 nM) V1A receptors and potently antagonizes arginine vasopressin-induced effects in vitro (IC50 = 3.7 nM for inhibition of human platelet aggregation) and is orally active in vivo.
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纯度 & 质量文件
批次:
靶点选择性
生物活性
- 描述
- 参考文献
- [1] Hawtin SR. Pharmacological chaperone activity of SR49059 to functionally recover misfolded mutations of the vasopressin V1a receptor. J Biol Chem. 2006 May 26;281(21):14604-14.
- [2] Thibonnier M, Kilani A, et al. Effects of the nonpeptide V(1) vasopressin receptor antagonist SR49059 in hypertensive patients. Hypertension. 1999 Dec;34(6):1293-300.
实验方案
- 计算器
- 储存液制备
技术信息
| CAS号 | 150375-75-0 | 储存条件 |
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| 分子式 | C28H27Cl2N3O7S | 运输 | 蓝冰 | |
| 分子量 | 620.50 | 别名 | Relcovaptan |
