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CAS No.: 658084-23-2

SU11274 Catalog No. CSN12733

Synonyms: PKI-SU11274;Met Kinase Inhibitor

SU11274 is a selective Met inhibitor with IC50 of 10 nM, no effects on PGDFRβ, EGFR or Tie2.

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实验方案

技术信息

生物活性

描述SU11274 is a selective Met inhibitor with IC50 of 10 nM, no effects on PGDFRβ, EGFR or Tie2.
细胞研究

Cell Data

Cell Lines	Concentration	Assay Type	Time	Activity Description	Data Sources
A549 cells	-	Function assay	-	Inhibition of human recombinant c-MET kinase in A549 cells assessed as inhibition of HGF-induced cell growth, IC50=0.01 μM	21812414
DLD1 cells	2.5 μM	Function assay	-	Inhibition of human p38-alpha phosphorylation in DLD1 cells at 2.5 μM	17595299
DLD1 cells	2.5 μM	Function assay	16 h	Inhibition of human MET receptor in DLD1 cells at 2.5 uM after 16 hrs by Western blot	17595299

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 1.7603 mL
- 8.8015 mL
- 17.6029 mL
- 5 mM
- 0.3521 mL
- 1.7603 mL
- 3.5206 mL
- 10 mM
- 0.1760 mL
- 0.8801 mL
- 1.7603 mL

技术信息

CAS号	658084-23-2	储存条件	粉末 Sealed in dry,2-8°C 液体 -20°C:3-6 月 -80°C:12月
分子式	C28H30ClN5O4S	运输	蓝冰
分子量	568.09	别名	PKI-SU11274;Met Kinase Inhibitor

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Cell Lines	Concentration	Assay Type	Time	Activity Description	Data Sources

A549 cells	-	Function assay	-	Inhibition of human recombinant c-MET kinase in A549 cells assessed as inhibition of HGF-induced cell growth, IC50=0.01 μM	21812414
DLD1 cells	2.5 μM	Function assay	-	Inhibition of human p38-alpha phosphorylation in DLD1 cells at 2.5 μM	17595299
DLD1 cells	2.5 μM	Function assay	16 h	Inhibition of human MET receptor in DLD1 cells at 2.5 uM after 16 hrs by Western blot	17595299
human BxPC3 cells	-	Proliferation assay	72 h	Antiproliferative activity against human BxPC3 cells after 72 hrs	21405128
human HepG2 cells	-	Function assay	-	Inhibition of Met-mediated tumorigenesis in HGF-stimulated human HepG2 cells assessed as impairment in anchorage-independent growth by soft agar growth assay, IC50=1.561 μM	22138308
human MCF7 cells	-	Proliferation assay	72 h	Antiproliferative activity against human MCF7 cells after 72 hrs, IC50=6.2 μM	21405128
human MDA-MB-231 cells	-	Proliferation assay	72 h	Antiproliferative activity against human MDA-MB-231 cells after 72 hrs	21405128
human MDCK cells	-	Function assay	24 h	Inhibition of Met-mediated scattering in HGF-stimulated human MDCK cells pre-incubated overnight prior to HGF stimulation for 24 hrs measured after 24 to 48 hrs, IC50=0.152 μM	22138308
human MKN45 cells	-	Proliferation assay	72 h	Antiproliferative activity against human MKN45 cells after 72 hrs, IC50=1.3 μM	21405128
human NCI-H1993 cells	-	Proliferation assay	72 h	Antiproliferative activity against human NCI-H1993 cells after 72 hrs, IC50=7.3 μM	21405128
human NCI-H441 cells	-	Proliferation assay	72 h	Antiproliferative activity against human NCI-H441 cells after 72 hrs	21405128
human SNU1 cells	-	Proliferation assay	72 h	Antiproliferative activity against human SNU1 cells after 72 hrs, IC50=7 μM	21405128
human SNU5 cells	-	Proliferation assay	72 h	Antiproliferative activity against human SNU5 cells after 72 hrs, IC50=0.8 μM	21405128
mouse BAF3 cells	-	Proliferation assay	72 h	Antiproliferative activity against mouse BAF3 cells expressing TPR-Met after 72 hrs in absence of IL-3, IC50=0.53 μM	21405128
mouse NIH/3T3 cells	-	Proliferation assay	72 h	Antiproliferative activity against mouse NIH/3T3 cells expressing TPR-Met after 72 hrs, IC50=2 μM	21405128

SU11274 Catalog No. CSN12733

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