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CAS No.: 94055-76-2

Suplatast (Tosilate)/甲磺司特 Catalog No. CSN12018

Synonyms: IPD 1151T;Suplatast (tosylate);Suplatast tosilate

Suplatast Tosylate is an inhibitor of Th2 cytokine synthesis which can attenuate IL-2, IL-5 and IL-13 production and has no effect on IFN-γ production.

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生物活性

描述Type 2 helper T cells (Th2) are essential for allergen-induced bronchial hyperresponsiveness and eosinophilic inflammation. Suplatast tosilate is an anti-allergic drug that suppresses IgE synthesis in both mice and humans without affecting total IgG and IgM production^[3]. Suplatast tosilate at 1–10µg/mL suppresses human IgE synthesis in a concentration-dependent manner. Suplatast tosilate at 10µg/mL reduced the mRNA level of IL-4 in phytohemagglutinin-stimulated human peripheral blood mononuclear cells^[4]. In ovalbumin (OVA)-challenged mice, treatment with 100mg/kg suplatast tosilate significantly decreases the number of total cells and eosinophils in bronchoalveolar lavage fluid compared with OVA control mice. Mice treated with suplatast tosilate also show significantly lower levels of IL-4, IL-5, and IL-13 in mice in comparison with the controls^[3].
参考文献

[1] Tamaoki J, Kondo M, et al. Effect of suplatast tosilate, a Th2 cytokine inhibitor, on steroid-dependent asthma: a double-blind randomised study. Tokyo Joshi-Idai Asthma Research Group. Lancet. 2000;356(9226):273-8.
[2] Iijima H, Tamura G, et al. Suplatast tosilate inhibits late response and airway inflammation in sensitized guinea pigs. Am J Respir Crit Care Med. 1999;160(1):331-5
[3] Zhao GD, Yokoyama A, Kohno N, Sakai K, Hamada H, Hiwada K. Effect of suplatast tosilate (IPD-1151T) on a mouse model of asthma: inhibition of eosinophilic inflammation and bronchial hyperresponsiveness. Int Arch Allergy Immunol. 2000;121(2):116-122.
[4] Yanagihara Y, Kiniwa M, Ikizawa K, Shida T, Matsuura N, Koda A. Suppression of IgE production by IPD-1151T (suplatast tosilate), a new dimethylsulfonium agent: (2). Regulation of human IgE response. Jpn J Pharmacol. 1993;61(1):31-39.

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.0014 mL
- 10.0072 mL
- 20.0144 mL
- 5 mM
- 0.4003 mL
- 2.0014 mL
- 4.0029 mL
- 10 mM
- 0.2001 mL
- 1.0007 mL
- 2.0014 mL

技术信息

CAS号

94055-76-2

储存条件

粉末: Inert atmosphere,Room Temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C23H33NO7S2

运输

蓝冰

分子量

499.64

别名

IPD 1151T;Suplatast (tosylate);Suplatast tosilate;甲磺司特

溶解度

DMSO	215.0 mg/mL (430.3 mM)
Water	370.0 mg/mL (740.5 mM)

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