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CAS No.: 163847-77-6

TAPI-1 Catalog No. CSN17979

Synonyms: TAPI-1

TAPI-1 is a specific TACE (TNF-α-converting enzyme) inhibitor.

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纯度 & 质量文件批次:

靶点选择性

生物活性

实验方案

技术信息

生物活性

描述TAPI-1 is a TACE (ADAM-17) and MMP inhibitor. It could inhibit the processing of TNF. Treatment with TAPI-1 at concentration ranging in 12.5-200μM led to a dose-dependent reduction of TNF stimulated by LPS in both THP-1 cells and peripheral blood T cells. Administration of 1mg TAPI-1 subcutaneously could protect the mice from the lethal dose of LPS. TAPI-1 at concentration of 2μM could suppress sIL-6R production in THP-1 macrophages and THP-1 cells after 12-hour treatment. And also this treatment significantly suppressed IL-1β-induced increases in the expression OPN mRNA and production of OPN, but exhibited no effect on OPN without IL-1β stimulation.
参考文献

[1] Zhang Y, Zhu M, et al. The human Cathelicidin LL-37 induces MUC5AC mucin production by airway epithelial cells via TACE-TGF-α-EGFR pathway. Exp Lung Res. 2014 Sep;40(7):333-42.
[2] Zhao XQ, Zhang MW, et al. CRP enhances soluble LOX-1 release from macrophages by activating TNF-α converting enzyme. J Lipid Res. 2011 May;52(5):923-33.

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.0016 mL
- 10.0080 mL
- 20.0160 mL
- 5 mM
- 0.4003 mL
- 2.0016 mL
- 4.0032 mL
- 10 mM
- 0.2002 mL
- 1.0008 mL
- 2.0016 mL

技术信息

CAS号

163847-77-6

储存条件

粉末: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C26H37N5O5

运输

蓝冰

分子量

499.60

别名

TAPI-1

溶解度

DMSO	31.0 mg/mL (62.0 mM)

动物实验配方

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