CAS No.: 701977-09-5
Taranabant Catalog No. CSN12382
Synonyms: MK-0364
Taranabant is a cannabinoid 1 receptor inverse agonist with IC50 of 0.3 nM.
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纯度 & 质量文件
批次:
靶点选择性
生物活性
- 描述
- 临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点 NCT00109135 Smoking Phase 2 Completed - - NCT00131391 Obesity Phase 3 Terminated(The overall profile... more >> does not support development for obesity) Collapse << - - NCT00131430 Obesity and Obesity-related Me... more >>dical Conditions Collapse << Phase 2 Phase 3 Completed - - - 更多
- 参考文献
- [1] Fong TM, Guan XM, et al. Antiobesity efficacy of a novel cannabinoid-1 receptor inverse agonist, N-[(1S,2S)-3-(4-chlorophenyl)-2-(3-cyanophenyl)-1-methylpropyl] -2-methyl-2-[[5-(trifluoromethyl)pyridin-2-yl] oxy] propanamide (MK-0364), in rodents. J Pharmacol Exp Ther. 2007 Jun;321(3):1013-22.
- [2] Lin LS, Lanza TJ Jr, et al. Discovery of N-[(1S,2S)-3-(4-Chlorophenyl)-2-(3-cyanophenyl)-1-methylpropyl] -2-methyl-2- {[5-(trifluoromethyl)pyridin-2-yl] oxy}propanamide (MK-0364), a novel, acyclic cannabinoid-1 receptor inverse agonist for the treatment of obesity. J Med Chem. 2006 Dec 28;49(26):7584-7.
实验方案
- 计算器
- 储存液制备
技术信息
| CAS号 | 701977-09-5 | 储存条件 |
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| 分子式 | C27H25ClF3N3O2 | 运输 | 蓝冰 | |
| 分子量 | 515.95 | 别名 | MK-0364 |
