|N,N'-(磺酰双(4,1-亚苯基))双(2-氯乙酰胺)|CsnPharm

CAS No.: 17328-16-4

Synonyms: NSC 30176

TC-E 5003 is a selective protein arginine methyltransferase 1 (PRMT1) inhibitor.

规格	价格	促销价格	库存	数量

400-920-2911

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400-920-2911

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描述Protein arginine methyltransferase 1 (PRMT1) is a major type 1 arginine methyltransferase associated with the activation of estrogen and androgen receptors; therefore, may represent a therapeutic target for hormone-dependent cancers. TC-E 5003 is an inhibitor of PRMT1 with an IC50 value of 1.5±0.2µM. The GI50 value of TC-E 5003 for the growth of MCF7a and LNCaP cell lines are 1.97 ± 0.14 and 4.49 ± 0.14µM, respectively.^[1] TC-E 5003 at concentrations of 0.125 – 1µM dose-dependently suppressed lipopolysaccharide-induced nitric oxide (NO) production in RAW264.7 cells. Treatment with TC-E 5003 also markedly reduced the expressions of inducible NO synthase, cyclooxygenase-2, tumor necrosis factor-α, interleukin (IL)-1β, and IL-6, and downregulated the nuclear translocation of nuclear factor kappa B subunits.^[2] TC-E-5003 at a dose of 0.5mg exerted an anti-tumor effect (31.76%) in A549 tumor-bearing mice.^[3]
作用机制 TC-E 5003 is a selective inhibitor of PRMT1.^[1]
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技术信息

CAS号	17328-16-4	储存条件	粉末 Inert atmosphere,Room Temperature 液体 -20°C:3-6 月 -80°C:12月
分子式	C16H14Cl2N2O4S	运输	蓝冰
分子量	401.26	别名	NSC 30176

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