生物活性

• 描述TCID is a DUB inhibitor for ubiquitin C-terminal hydrolase L3 with IC50 of 0.6 μM, 125-fold selective to L1.
• 临床研究

• NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
  NCT02376400	Healthy	Phase 1	Completed	-	Tanzania ... more >> Mwanza, Tanzania Uganda Entebbe, Uganda Collapse <<
  NCT00998192	Metastatic or Recurrent Squamo... more >>us Cell Carcinoma of the Lung Collapse <<	Phase 2	Completed	-	United States, California ... more >> Cedars-Sinai Medical Center Los Angeles, California, United States, 90048 United States, Florida Ocala Oncology Center Ocala, Florida, United States, 34471 United States, Illinois Illinois Cancer Specialists Niles, Illinois, United States, 60714 United States, Indiana Investigative Clinical Research of Indiana, LLC Indianapolis, Indiana, United States, 46260 United States, New York Advanced Oncology Associates Armonk, New York, United States, 10504 United States, Ohio Signal Point Clinical Research Center, LLC Middletown, Ohio, United States, 45042 United States, Pennsylvania Medical Oncology Associates of Wyoming Valley Kingston, Pennsylvania, United States, 18704 United States, Texas Texas Oncology - Arlington South Arlington, Texas, United States, 76014 Texas Oncology - Bedford Bedford, Texas, United States, 76022 Texas Oncology - Denton South Denton, Texas, United States, 76210 Texas Oncology - Fort Worth Fort Worth, Texas, United States, 76104 Texas Oncology - Garland Garland, Texas, United States, 75042 Texas Oncology - Lewisville Lewisville, Texas, United States, 75067 Cancer Therapy & Research Center at UTHSCSA San Antonio, Texas, United States, 78229 Cancer Care Centers of South Texas San Antonio, Texas, United States, 78258-3912 Texas Oncology - Tyler Tyler, Texas, United States, 75702 United States, Virginia Lynchburg Hematology Oncology Clinic Lynchburg, Virginia, United States, 24501 Collapse <<
  NCT00753038	Carcinoma, Squamous Cell of th... more >>e Head and Neck Collapse <<	Phase 2	Completed	-	United States, New York ... more >> Montefiore Medical Center Bronx, New York, United States, 10467 United States, Texas Cancer Therapy and Research Center at UTHSCSA San Antonio, Texas, United States, 78229 Collapse <<

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• 参考文献

• [1] Martinez-Villarreal J, Garcia Tardon N, et al. Cell surface turnover of the glutamate transporter GLT-1 is mediated by ubiquitination/deubiquitination. Glia. 2012 Sep;60(9):1356-65.

  [2] Liu Y, Lashuel HA, et al. Discovery of inhibitors that elucidate the role of UCH-L1 activity in the H1299 lung cancer cell line. Chem Biol. 2003 Sep;10(9):837-46.