|(R)-((1-(6-氨基-9H-嘌呤-9-基)丙烷-2-基)氧基)甲基)膦酸水合物|CsnPharm

CAS No.: 206184-49-8

Tenofovir hydrate/替诺福韦水合物 Catalog No. CSN10187

Synonyms: GS 1278 hydrate;PMPA hydrate;TDF Hydrate

Tenofovir is a nucleotide analogue reverse transcriptase inhibitors (NRTIs) which reduces the viral cytopathic effect of HIV-1 (IIIB), HIV-2(ROD) with EC50 of 1.15 μg/ml and 1.12 μg/ml.

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实验方案

技术信息

生物活性

描述Tenofovir is an antiretroviral drug known as nucleotide analogue reverse transcriptase inhibitors (NRTIs), which block reverse transcriptase, a crucial virus enzyme in HIV-1 and HBV.
临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT01475851	Hepatitis B, Chronic	Phase 3	Completed	-	Japan ... more >> GSK Investigational Site Aichi, Japan, 466-8560 GSK Investigational Site Aichi, Japan, 467-8602 GSK Investigational Site Chiba, Japan, 260-8677 GSK Investigational Site Fukuoka, Japan, 803-8505 GSK Investigational Site Hiroshima, Japan, 734-8551 GSK Investigational Site Hokkaido, Japan, 060-0033 GSK Investigational Site Kagoshima, Japan, 890-8520 GSK Investigational Site Kanagawa, Japan, 213-8587 GSK Investigational Site Miyagi, Japan, 980-8574 GSK Investigational Site Tokyo, Japan, 105-8470 GSK Investigational Site Tokyo, Japan, 180-8610 Collapse <<
NCT01475851	-	-	Completed	-	-
NCT01480284	-	-	Completed	-	-

更多
参考文献

[1] Kumada H, Koike K, et al. Efficacy and safety of tenofovir disoproxil fumarate rescue therapy for chronic hepatitis B patients who failed other nucleos(t)ide analogs. Hepatol Res. 2016 Nov 15.
[2] Witvrouw M, et al. Susceptibility of HIV-2, SIV and SHIV to various anti-HIV-1 compounds: implications for treatment and postexposure prophylaxis. Antivir Ther. 2004 Feb;9(1):57-65.

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 3.2762 mL
- 16.3811 mL
- 32.7622 mL
- 5 mM
- 0.6552 mL
- 3.2762 mL
- 6.5524 mL
- 10 mM
- 0.3276 mL
- 1.6381 mL
- 3.2762 mL

技术信息

CAS号

206184-49-8

储存条件

粉末: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C9H16N5O5P

运输

蓝冰

分子量

305.23

别名

GS 1278 hydrate;PMPA hydrate;TDF Hydrate;替诺福韦水合物

溶解度

DMSO	5.0 mg/mL (16.4 mM)

动物实验配方

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NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点

NCT01475851	Hepatitis B, Chronic	Phase 3	Completed	-	Japan ... more >> GSK Investigational Site Aichi, Japan, 466-8560 GSK Investigational Site Aichi, Japan, 467-8602 GSK Investigational Site Chiba, Japan, 260-8677 GSK Investigational Site Fukuoka, Japan, 803-8505 GSK Investigational Site Hiroshima, Japan, 734-8551 GSK Investigational Site Hokkaido, Japan, 060-0033 GSK Investigational Site Kagoshima, Japan, 890-8520 GSK Investigational Site Kanagawa, Japan, 213-8587 GSK Investigational Site Miyagi, Japan, 980-8574 GSK Investigational Site Tokyo, Japan, 105-8470 GSK Investigational Site Tokyo, Japan, 180-8610 Collapse <<
NCT01475851	-	-	Completed	-	-
NCT01480284	-	-	Completed	-	-
NCT01480284	Hepatitis B, Chronic	Phase 3	Completed	-	Japan ... more >> GSK Investigational Site Aichi, Japan, 466-8560 GSK Investigational Site Aichi, Japan, 467-8602 GSK Investigational Site Chiba, Japan, 260-8677 GSK Investigational Site Fukui, Japan, 918-8503 GSK Investigational Site Fukuoka, Japan, 803-8505 GSK Investigational Site Fukuoka, Japan, 810-8539 GSK Investigational Site Fukuoka, Japan, 812-8582 GSK Investigational Site Fukuoka, Japan, 820-8505 GSK Investigational Site Gifu, Japan, 500-8717 GSK Investigational Site Hiroshima, Japan, 734-8530 GSK Investigational Site Hyogo, Japan, 651-2273 GSK Investigational Site Hyogo, Japan, 663-8501 GSK Investigational Site Kagawa, Japan, 760-8557 GSK Investigational Site Kagoshima, Japan, 890-8520 GSK Investigational Site Kagoshima, Japan, 892-8512 GSK Investigational Site Kanagawa, Japan, 213-8587 GSK Investigational Site Kumamoto, Japan, 862-8655 GSK Investigational Site Miyagi, Japan, 980-8574 GSK Investigational Site Miyazaki, Japan, 880-0003 GSK Investigational Site Nagasaki, Japan, 852-8501 GSK Investigational Site Nagasaki, Japan, 856-8562 GSK Investigational Site Nara, Japan, 630-8305 GSK Investigational Site Okayama, Japan, 700-0913 GSK Investigational Site Okayama, Japan, 700-8511 GSK Investigational Site Osaka, Japan, 540-0006 GSK Investigational Site Osaka, Japan, 564-0013 GSK Investigational Site Saga, Japan, 840-8571 GSK Investigational Site Tokyo, Japan, 105-8470 GSK Investigational Site Tokyo, Japan, 105-8471 GSK Investigational Site Tokyo, Japan, 140-8522 GSK Investigational Site Tokyo, Japan, 162-8655 GSK Investigational Site Tokyo, Japan, 180-8610 Collapse <<

Tenofovir hydrate/替诺福韦水合物 Catalog No. CSN10187

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