165538-40-9|Terutroban|CsnPharm

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CAS No.: 165538-40-9

Terutroban Catalog No. CSN17989

Synonyms: S-18886;Triplion

Terutroban is a thromboxane/prostaglandin endoperoxide receptor antagonist.

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靶点选择性

生物活性

描述TP (thromboxane-A2 /prostaglandin-endoperoxide)-receptor blockade with terutroban decreases portal pressure in cirrhosis^[3]. Terutroban is a selective TP receptor antagonist, i.e. a specific antagonist of the thromboxane A(2) and prostaglandin endoperoxide receptors, shown to improve endothelial function after a single administration in patients with coronary artery disease. It can chronically improve endothelium-dependent vasodilatation and inhibiting platelet aggregation^[4]. Terutroban prevents the development of aorta hyperplasia and has beneficial effects on fibrotic processes by affecting TGF-β and heat shock protein-47 expression in SHRSPs(spontaneously hypertensive stroke-prone rats)^[5]. Terutroban significantly protected retinal vascularity from ischaemia in experimental diabetes, and this result could be attributed not only to its antiplatelet/antithrombotic activities but also to its vascular properties^[6]. In PAD (peripheral arterial disease) patients, terutroban dose-dependently inhibited platelet aggregation 24 h after dosing, and was at least as effective as aspirin at 5, 10 and 30 mg day(-1). Terutroban was well tolerated^[7].
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.4515 mL
- 12.2576 mL
- 24.5152 mL
- 5 mM
- 0.4903 mL
- 2.4515 mL
- 4.9030 mL
- 10 mM
- 0.2452 mL
- 1.2258 mL
- 2.4515 mL

技术信息

CAS号

165538-40-9

储存条件

粉末: Sealed in dry,Store in freezer, under -20°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C20H22ClNO4S

运输

蓝冰

分子量

407.91

别名

S-18886;Triplion

溶解度

DMSO	21.0 mg/mL (51.5 mM)

动物实验配方

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总药量计算器 ✕

动物实验：给药剂量mg/kg 动物体重g 动物数量只每天给药次给药天

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工作液计算器 ✕

动物实验：给药剂量mg/kg 动物体重g 给药体积μL

您需要配制的工作液浓度为：mg/mL

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