CAS No.: 639089-54-6
Tozasertib/陶扎色替 Catalog No. CSN12326
Synonyms: VX 680;MK-0457;VE-465
Tozasertib is the inhibitor of Aurora-A, -B, -C kinases with Ki values of 0.6, 18, 4.6 nM respectively.
| 规格 | 价格 | 促销价格 | 库存 | 数量 |
|---|
400-920-2911
sales@csnpharm.cn
tech@csnpharm.cn
纯度 & 质量文件
批次:
靶点选择性
生物活性
靶点 Aurora Kinase A
Ki:0.6nMAurora Kinase B
Ki:18NmAurora Kinase C
Ki:4.6nM- 描述
- 作用机制
- 细胞研究
- Cell Data
- 更多
- 临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点 NCT00500006 Chronic Myelogenous Leukemia ... more >> Leukemia, Lymphoblastic, Acute, Philadelphia-Positive Collapse << Phase 1 Terminated - - NCT00405054 Leukemia Phase 2 Terminated - - NCT00290550 Carcinoma, Non-Small-Cell Lung Phase 2 Terminated - - - 更多
- 参考文献
- [1] Harrington EA, Bebbington D, et al. VX-680, a potent and selective small-molecule inhibitor of the Aurora kinases, suppresses tumor growth in vivo. Nat Med. 2004 Mar;10(3):262-7. Epub 2004 Feb 22.
- [2] Winter GE, Rix U, et al. An integrated chemical biology approach identifies specific vulnerability of Ewing's sarcoma to combined inhibition of Aurora kinases A and B. Mol Cancer Ther. 2011;10(10):1846-56.
实验方案
- 计算器
- 储存液制备
技术信息
| CAS号 | 639089-54-6 | 储存条件 |
|
|||||||||
| 分子式 | C23H28N8OS | 运输 | 蓝冰 | |||||||||
| 分子量 | 464.59 | 别名 | VX 680;MK-0457;VE-465 | |||||||||
| 溶解度 |
|
动物实验配方 |
|
