生物活性

• 描述Trabectedin is an antitumour agent of marine origin with potent antitumour activity both in vitro and in vivo.
• 临床研究

• NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
  NCT01692496	Advanced and / or Metastatic L... more >>iposarcoma Collapse <<	Phase 2	Completed	-	Germany ... more >> HELIOS Klinikum Berlin-Buch (Sarkomzentrum Berlin-Brandenburg) Berlin, Germany, D-10707 Universitätsklinikum EssenInnere Klinik (Tumorforschung) Essen, Germany, D-45147 Medizinische Hochschule Hannover (Zentrum Innere Medizin) Hannover, Germany, D-30625 Universitätsmedizin Mannheim (Sarkomzentrum) Manheim, Germany, D-68169 Klinikum Großhadern der LMU Universität München (Med. Klinik und Poliklinik II) Munich, Germany, D-80336 Spain Hospital Central de Asturias Oviedo, Asturias, Spain, 33011 Hospital Universitario de Canarias La Laguna, Islas Canarias, Spain, 38320 Hospital de Navarra Pamplona, Navarra, Spain, 31008 Complejo Hospitalario Universitario de Vigo Vigo, Pontevedra, Spain, 36204 Hospital Vall d'Hebrón Barcelona, Spain, 08035 Hospital 12 de Octubre Madrid, Spain, 28041 Hospital Universitari Son Espases Palma de Mallorca, Spain, 07010 Hospital Universitario Virgen del Rocío Sevilla, Spain, 41013 Instituto Valenciano de Oncología Valencia, Spain, 46009 Hospital Miguel Servet Zaragoza, Spain, 50009 Collapse <<
  NCT03056599	Soft Tissue Sarcoma Adult	Phase 1	Recruiting	December 31, 2019	United States, New York ... more >> Monter Cancer Center (Northwell Health) Recruiting Lake Success, New York, United States, 11042 Contact: Sharon Fox          Principal Investigator: Gary Deutsch, MPH, MD          Sub-Investigator: Robert Maki, MD, PHD          Sub-Investigator: Tony Philip, MD          Sub-Investigator: Mee-young Lee, NP          Sub-Investigator: Shamsah Lakhani, PA          Sub-Investigator: Priscila Goncalves, MD          Sub-Investigator: Eran Ben-Levi, MD          Sub-Investigator: Daniel Ramirez, MD          Sub-Investigator: Brian Burke, MD          Sub-Investigator: Howard Goodman, MD          United States, Oregon OHSU Knight Cancer Institute Recruiting Portland, Oregon, United States, 97239 Contact: Sierra Bertolone-Smith          Principal Investigator: Kenneth Gundle, MD          United States, Washington Fred Hutchinson Cancer Research Center Recruiting Seattle, Washington, United States, 98109 Contact: Taylor Hain          Principal Investigator: Seth Pollack, MD          University of Washington Recruiting Seattle, Washington, United States, 98195 Contact: Taylor Hain          Sub-Investigator: Darin Davidson, MD          Sub-Investigator: Matthew Thompson, MD Collapse <<
  NCT01710176	Localized High-risk Soft Tissu... more >>e Sarcomas of the Extremities and Trunk Wall in Adults Collapse <<	Phase 3	Recruiting	January 2021	Italy ... more >> Irccs Centro Di Riferimento Oncologico (Cro) - Recruiting Aviano (pn), Italy Irccs Istituto Ortopedico Rizzoli (Ior) - Recruiting Bologna (BO), Italy Pres.Ospedal.Spedali Civili Brescia - Recruiting Brescia (BS), Italy Fondazione Del Piemonte Per L'Oncologia Ircc Di Candiolo - Recruiting Candiolo (TO), Italy Irst - Istituto Scientifico Romagnolo Per Lo Studio E La Cura Dei Tumori - Recruiting Meldola (fc), Italy Irccs Istituto Europeo Di Oncologia (Ieo) - Recruiting Milano (MI), Italy Irccs Istituto Nazionale Dei Tumori (Int) Recruiting Milano (MI), Italy Irccs Istituto Nazionale Tumori Fondazione Pascale - Not yet recruiting Napoli (NA), Italy Irccs Istituto Oncologico Veneto (Iov) Recruiting Padova, Italy Irccs Istituto Regina Elena (Ifo) Recruiting Roma (rm), Italy Irccs Istituto Clinico Humanitas - Recruiting Rozzano (mi), Italy Presidio Sanitario Gradenigo Di Torino Not yet recruiting Torino (TO), Italy Spain Hospital Vall D'Hebron Recruiting Barcelona, Spain Hospital Clínico de Malaga Recruiting Malaga, Spain Hospital Son Espases Recruiting Palma de Mallorca, Spain Collapse <<

• 更多
• 参考文献

• [1] Atmaca H, Bozkurt E, et al. A diverse induction of apoptosis by trabectedin in MCF-7 (HER2-/ER+) and MDA-MB-453 (HER2+/ER-) breast cancer cells. Toxicol Lett. 2013 Aug 14;221(2):128-36.

  [2] Takahashi N, Li W, et al. Sequence-dependent synergistic cytotoxicity of ecteinascidin-743 and paclitaxel in human breast cancer cell lines in vitro and in vivo. Cancer Res. 2002 Dec 1;62(23):6909-15.