CAS No.: 53902-12-8
Tranilast/曲尼司特 Catalog No. CSN12122
Synonyms: 曲尼司特;MK-341;SB 252218
Tranilast can antagonize angiotensin II and also work as an antiallergic agent. It showed inhibitory effect for NLRP3 inflammasome but not for NLRC4 or AIM2 inflammasome. Tranilast impaired the endogenous NLRP3-ASC interaction but did not affect the NLRP3-NEK7 interaction, raising the possibility that it targets NLRP3 directly.
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纯度 & 质量文件
批次:
靶点选择性
生物活性
- 描述
- 临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点 NCT00818805 Allergic Conjunctivitis Phase 4 Completed - - NCT01109121 Moderate to Severe Gout ... more >> Hyperuricemia Collapse << Phase 2 Completed - - NCT01052987 Gout Hyperuri... more >>cemia Collapse << Phase 2 Completed - United States, Hawaii ... more >> Nuon Investigative Site Honolulu, Hawaii, United States United States, Indiana Nuon Investigative Site Evansville, Indiana, United States United States, Texas Nuon Investigative Site Dallas, Texas, United States Collapse << - 更多
- 参考文献
- [1] Suzawa H, et al. Jpn J Pharmacol, 1992, 60(2), 91-96.
- [2] Suzawa H, et al. Jpn J Pharmacol, 1992, 60(2), 85-90.
- [3] Harigai R, Sakai S, Nobusue H, Hirose C, Sampetrean O, Minami N, Hata Y, Kasama T, Hirose T, Takenouchi T, Kosaki K, Kishi K, Saya H, Arima Y. Tranilast inhibits the expression of genes related to epithelial-mesenchymal transition and angiogenesis in neurofibromin-deficient cells. Sci Rep. 2018 Apr 17;8(1):6069. doi: 10.1038/s41598-018-24484-y. PMID: 29666462; PMCID: PMC5904101.
- [4] Nakashima T, Nagano S, Setoguchi T, Sasaki H, Saitoh Y, Maeda S, Komiya S, Taniguchi N. Tranilast enhances the effect of anticancer agents in osteosarcoma. Oncol Rep. 2019 Jul;42(1):176-188. doi: 10.3892/or.2019.7150. Epub 2019 May 6. PMID: 31059083; PMCID: PMC6549073.
实验方案
- 计算器
- 储存液制备
技术信息
| CAS号 | 53902-12-8 | 储存条件 |
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| 分子式 | C18H17NO5 | 运输 | 蓝冰 | |||||||||
| 分子量 | 327.33 | 别名 | 曲尼司特;MK-341;SB 252218;3,4-DAA | |||||||||
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动物实验配方 |
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