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CAS No.: 22255-22-7

trans-Trimethoxyresveratrol/白藜芦醇三甲醚 Catalog No. CSN19327

Synonyms: trans-trismethoxy Resveratrol;E-Resveratrol Trimethyl Ether;Tri-O-methylresveratrol

trans-Trimethoxyresveratrol is a derivative of resveratrol (RSV),and it may be a more potent anti-inflammatory, antiangiogenic and vascular-disrupting agent when compared with resveratrol.

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生物活性

描述Trans-Trimethoxyresveratrol is a derivative of Resveratrol (RSV),and it may be a more potent anti-inflammatory, antiangiogenic and vascular-disrupting agent when compared with resveratrol. Trans-3,5,4'-Trimethoxystilbene showed significantly more potent antiangiogenic activity . In zebrafish, trans-3,5,4'-trimethoxystilbene caused intersegmental vessel regression and downregulated VEGFR2 mRNA expression. Trans-3,5,4'-trimethoxystilbene also induced G2/M cell-cycle arrest, most specifically in endothelial cells of zebrafish embryos^[3]. Methoxylated (pterostilbene, pinostilbene, trans-trimethoxy-resveratrol, and CAY10616) (0.1-10 μM) inhibited Caco-2 cell growth, with a higher potency than resveratrol (50% inhibition at 0.1-1 μM) but without effects on oxidative stress and arachidonic acid cascade^[4].
参考文献

[1] Pastorkova B, Vrzalova A, et al. Hydroxystilbenes and methoxystilbenes activate human aryl hydrocarbon receptor and induce CYP1A genes in human hepatoma cells and human hepatocytes. Food Chem Toxicol. 2017 May;103:122-132.
[2] Alex D, Leong EC, et al. Resveratrol derivative, trans-3,5,4'-trimethoxystilbene, exerts antiangiogenic and vascular-disrupting effects in zebrafish through the downregulation of VEGFR2 and cell-cycle modulation. J Cell Biochem. 2010 Feb 1;109(2):339-46.
[3] Alex D, Leong EC, Zhang ZJ, et al. Resveratrol derivative, trans-3,5,4'-trimethoxystilbene, exerts antiangiogenic and vascular-disrupting effects in zebrafish through the downregulation of VEGFR2 and cell-cycle modulation. J Cell Biochem. 2010;109(2):339-346
[4] Storniolo CE, Moreno JJ. Resveratrol Analogs with Antioxidant Activity Inhibit Intestinal Epithelial Cancer Caco-2 Cell Growth by Modulating Arachidonic Acid Cascade. J Agric Food Chem. 2019;67(3):819-828

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 3.6993 mL
- 18.4964 mL
- 36.9928 mL
- 5 mM
- 0.7399 mL
- 3.6993 mL
- 7.3986 mL
- 10 mM
- 0.3699 mL
- 1.8496 mL
- 3.6993 mL

技术信息

CAS号

22255-22-7

储存条件

粉末: Sealed in dry,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C17H18O3

运输

蓝冰

分子量

270.32

别名

trans-trismethoxy Resveratrol;E-Resveratrol Trimethyl Ether;Tri-O-methylresveratrol;(E)-5-[2-(4-hydroxyphenyl)ethenyl]-1,3-benzene diol;TMS;trans-3,5,4'-trimethoxystilbene;白藜芦醇三甲醚

溶解度

DMSO	48.0 mg/mL (177.6 mM)
Water	Insoluble

动物实验配方

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trans-Trimethoxyresveratrol/白藜芦醇三甲醚 Catalog No. CSN19327

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