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CAS No.: 141136-83-6

TRAP-6 Catalog No. CSN17809

Synonyms: PAR-1 agonist peptide;Thrombin Receptor Activator Peptide 6;SFLLRN

TRAP-6 is protease-activated receptor 1 (PAR1) agonist.

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靶点选择性

生物活性

实验方案

技术信息

生物活性

描述Proteinase-activated receptors (PARs) represent a unique subclass of G-protein-coupled receptors of which four family members have now been cloned from a number of species^[3]. PAR1 has been implicated as a key mediator in cellular functions and is activated by the PAR1 agonist, thrombin, as well as by serine proteases. TRAP-6 is a PAR1 agonist^[2]. Adenosine 5′-diphosphate (ADP) inducible aggregation which is used to assess platelet response to thienopyridines was correlated to that by TRAP-6 (r = 0.33 to 0.72; p < 0.001 for all assays)^[4]. In platelet-rich plasma (PRP) of patients (n = 34) with unexplained venous thromboembolism, platelet aggregometry was performed and the influence of TRAP-6 was determined. Compared to the control group, patients with venous thromboembolism showed an enhanced maximal platelet aggregation with low concentrations of TRAP-6 (2 μM)^[5].
临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT01824147	-	-	Completed	-	Germany ... more >> Goethe - University Frankfurt, Hessen, Germany, 60590 University Hospital Goettingen Goettingen, Lower Saxony, Germany, 37073 Collapse <<
NCT02817815	Atrial Fibrillation	Not Applicable	Not yet recruiting	September 2019	France ... more >> Service d'Electrophysiologie et de stimulation cardiaque / LIRYC - Hôpital Cardiologique du Haut Lévêque Not yet recruiting Pessac, France, 33604 Contact: Frédéric SACHER, Dr 0()5 57 65 64 71 ext +33 frederic.sacher@chu-bordeaux.fr Contact: Marion LEFEVRE (0)5 57 62 30 91 ext +33 marion.lefevre@chu-bordeaux.fr Principal Investigator: Frédéric SACHER, Dr Sub-Investigator: Mélèze HOCINI, Dr Sub-Investigator: Pierre JAIS, Pr Sub-Investigator: Nicolas DERVAL, Dr Sub-Investigator: Arnaud DENIS, Dr Collapse <<
NCT01178099	Anemia, Sickle Cell	Phase 1	Completed	-	United Kingdom ... more >> For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician. London, UK, United Kingdom, SE 1 1YR Collapse <<

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参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 1.3353 mL
- 6.6767 mL
- 13.3535 mL
- 5 mM
- 0.2671 mL
- 1.3353 mL
- 2.6707 mL
- 10 mM
- 0.1335 mL
- 0.6677 mL
- 1.3353 mL

技术信息

CAS号

141136-83-6

储存条件

粉末: Sealed in dry,Store in freezer, under -20°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C34H56N10O9

运输

蓝冰

分子量

748.87

别名

PAR-1 agonist peptide;Thrombin Receptor Activator Peptide 6;SFLLRN;SFLLRN-OH;Ser-Phe-Leu-Leu-Arg-Asn

溶解度

DMSO	150.0 mg/mL (200.3 mM)
Water	20.0 mg/mL (26.7 mM) warming

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NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点

NCT01824147	-	-	Completed	-	Germany ... more >> Goethe - University Frankfurt, Hessen, Germany, 60590 University Hospital Goettingen Goettingen, Lower Saxony, Germany, 37073 Collapse <<
NCT02817815	Atrial Fibrillation	Not Applicable	Not yet recruiting	September 2019	France ... more >> Service d'Electrophysiologie et de stimulation cardiaque / LIRYC - Hôpital Cardiologique du Haut Lévêque Not yet recruiting Pessac, France, 33604 Contact: Frédéric SACHER, Dr 0()5 57 65 64 71 ext +33 frederic.sacher@chu-bordeaux.fr Contact: Marion LEFEVRE (0)5 57 62 30 91 ext +33 marion.lefevre@chu-bordeaux.fr Principal Investigator: Frédéric SACHER, Dr Sub-Investigator: Mélèze HOCINI, Dr Sub-Investigator: Pierre JAIS, Pr Sub-Investigator: Nicolas DERVAL, Dr Sub-Investigator: Arnaud DENIS, Dr Collapse <<
NCT01178099	Anemia, Sickle Cell	Phase 1	Completed	-	United Kingdom ... more >> For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician. London, UK, United Kingdom, SE 1 1YR Collapse <<
NCT01837758	-	-	Completed	-	Germany ... more >> Johann Wolfgang Goethe-University Frankfurt, Hessen, Germany, 60590 Collapse <<
NCT01178099	-	-	Completed	-	-
NCT01789814	Coronary Artery Disease	Phase 4	Completed	-	United States, Massachusetts ... more >> Tufts Medical Center Boston, Massachusetts, United States, 02111 Collapse <<
NCT01789814	-	-	Completed	-	-
NCT03716310	-	-	Completed	-	Italy ... more >> Università di Ferrara Ferrara, Italy, 44121 Collapse <<
NCT03773731	Prediabetic State	Not Applicable	Not yet recruiting	February 2021	Austria ... more >> MUVienna Vienna, Austria, 1090 Collapse <<
NCT02930330	Atherosclerosis ... more >> Coronary Artery Disease Collapse <<	Not Applicable	Completed	-	Austria ... more >> MUVienna Vienna, Austria, 1090 Collapse <<

TRAP-6 Catalog No. CSN17809

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