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CAS No.: 105925-39-1

Tubulin inhibitor 6 Catalog No. CSN26703

Synonyms: iHAP1;Improved Heterocyclic Activator of PP2A 1;Tubulin Inhibitor 6

Tubulin inhibitor 6 (Compound 14b) is a tubulin inhibitor and a potent inhibitor of multiple cancer cell lines. Tubulin inhibitor 6 inhibits tubulin polymerization with an IC50 of 0.87 μM. Tubulin inhibitor 6 inhibits K562 cell growth with an IC50 of 840 nM[1].

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技术信息

生物活性

描述Tubulins play a key role in organizing the spatial distribution of organelles throughout interphase and of chromsomes during cell division. Tubulin inhibitor 6 is a tubulin inhibitor, which inhibits tubulin polymerization with an IC₅₀ of 0.87 μM. Tubulin inhibitor 6 displayed submicromolar antiproliferative activity with an IC₅₀ of 0.84 μM and inhibited K562 cell growth in vitro^[1].
参考文献

[1] Prinz H, et al. N-benzoylated phenoxazines and phenothiazines: synthesis, antiproliferative activity, and inhibition of tubulin polymerization. J Med Chem. 2011 Jun 23;54(12):4247-63

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.7185 mL
- 13.5925 mL
- 27.1851 mL
- 5 mM
- 0.5437 mL
- 2.7185 mL
- 5.4370 mL
- 10 mM
- 0.2719 mL
- 1.3593 mL
- 2.7185 mL

技术信息

CAS号

105925-39-1

储存条件

粉末: Sealed in dry,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C20H14ClNO2S

运输

蓝冰

分子量

367.85

别名

iHAP1;Improved Heterocyclic Activator of PP2A 1;Tubulin Inhibitor 6;CUN-25391

溶解度

DMSO	60.0 mg/mL (163.1 mM) warming

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Tubulin inhibitor 6 Catalog No. CSN26703

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