|N-[4-(2-叔丁基苯磺酰基)苯基]-2,3,4-三羟基-5-(2-异丙基苄基)苯甲酰胺|CsnPharm

CAS No.: 877877-35-5

TW-37 Catalog No. CSN16145

TW-37 is a nonpeptide inhibitor to recombinant Bcl-2, Bcl-xL and Mcl-1 with Ki of 0.29 μM, 1.11 μM and 0.26 μM, respectively.

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生物活性

实验方案

技术信息

生物活性

描述TW-37 is a nonpeptide inhibitor to recombinant Bcl-2, Bcl-xL and Mcl-1 with Ki of 0.29 μM, 1.11 μM and 0.26 μM, respectively.
细胞研究

Cell Data

Cell Lines	Concentration	Assay Type	Time	Activity Description	Data Sources
human A204 cell	-	Growth inhibition assay	-	Inhibition of human A204 cell growth in a cell viability assay, IC50=97.84 nM	SANGER
human A2780 cell	-	Growth inhibition assay	-	Inhibition of human A2780 cell growth in a cell viability assay, IC50=0.21846 μM	SANGER
human A375 cell	-	Growth inhibition assay	-	Inhibition of human A375 cell growth in a cell viability assay, IC50=88.83 nM	SANGER

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参考文献

[1] Zeitlin BD, Spalding AC, et al. Metronomic small molecule inhibitor of Bcl-2 (TW-37) is antiangiogenic and potentiates the antitumor effect of ionizing radiation. Int J Radiat Oncol Biol Phys. 2010 Nov 1;78(3):879-87.
[2] Wang et al (2009) TW-37, a small molecule inhibitor of Bcl-2, inhibits cell growth and induces apoptosis in pancreatic cancer: involvement of Notch-1 signaling pathway. Cancer Res. 69 2757.

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 1.7431 mL
- 8.7154 mL
- 17.4307 mL
- 5 mM
- 0.3486 mL
- 1.7431 mL
- 3.4861 mL
- 10 mM
- 0.1743 mL
- 0.8715 mL
- 1.7431 mL

技术信息

CAS号	877877-35-5	储存条件	粉末 Sealed in dry,2-8°C 液体 -20°C:3-6 月 -80°C:12月
分子式	C33H35NO6S	运输	蓝冰
分子量	573.70	别名

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Cell Lines	Concentration	Assay Type	Time	Activity Description	Data Sources

human A204 cell	-	Growth inhibition assay	-	Inhibition of human A204 cell growth in a cell viability assay, IC50=97.84 nM	SANGER
human A2780 cell	-	Growth inhibition assay	-	Inhibition of human A2780 cell growth in a cell viability assay, IC50=0.21846 μM	SANGER
human A375 cell	-	Growth inhibition assay	-	Inhibition of human A375 cell growth in a cell viability assay, IC50=88.83 nM	SANGER
human A427 cell	-	Growth inhibition assay	-	Inhibition of human A427 cell growth in a cell viability assay, IC50=44.69 nM	SANGER
human A549 cell	-	Growth inhibition assay	-	Inhibition of human A549 cell growth in a cell viability assay, IC50=14.09 nM	SANGER
human A673 cell	-	Growth inhibition assay	-	Inhibition of human A673 cell growth in a cell viability assay, IC50=53.85 nM	SANGER
human AGS cell	-	Growth inhibition assay	-	Inhibition of human AGS cell growth in a cell viability assay, IC50=37.53 nM	SANGER
human BHT-101 cell	-	Growth inhibition assay	-	Inhibition of human BHT-101 cell growth in a cell viability assay, IC50=21.83 nM	SANGER
human Ca9-22 cell	-	Growth inhibition assay	-	Inhibition of human Ca9-22 cell growth in a cell viability assay, IC50=3.82 nM	SANGER
human CHL-1 cell	-	Growth inhibition assay	-	Inhibition of human CHL-1 cell growth in a cell viability assay, IC50=11.9 nM	SANGER
human CP50-MEL-B cell	-	Growth inhibition assay	-	Inhibition of human CP50-MEL-B cell growth in a cell viability assay, IC50=69.59 nM	SANGER
human Daoy cell	-	Growth inhibition assay	-	Inhibition of human Daoy cell growth in a cell viability assay, IC50=0.14073 μM	SANGER
human DU-145 cell	-	Growth inhibition assay	-	Inhibition of human DU-145 cell growth in a cell viability assay, IC50=52.13 nM	SANGER
human GB-1 cell	-	Growth inhibition assay	-	Inhibition of human GB-1 cell growth in a cell viability assay, IC50=98.69 nM	SANGER
human GCIY cell	-	Growth inhibition assay	-	Inhibition of human GCIY cell growth in a cell viability assay, IC50=20.83 nM	SANGER
human HCT-116 cell	-	Growth inhibition assay	-	Inhibition of human HCT-116 cell growth in a cell viability assay, IC50=52.66 nM	SANGER
human HEC-1 cell	-	Growth inhibition assay	-	Inhibition of human HEC-1 cell growth in a cell viability assay, IC50=81.37 nM	SANGER
human HOS cell	-	Growth inhibition assay	-	Inhibition of human HOS cell growth in a cell viability assay, IC50=84.71 nM	SANGER
human Hs-578-T cell	-	Growth inhibition assay	-	Inhibition of human Hs-578-T cell growth in a cell viability assay, IC50=23.59 nM	SANGER
human HT-144 cell	-	Growth inhibition assay	-	Inhibition of human HT-144 cell growth in a cell viability assay, IC50=0.15201 μM	SANGER
human HuH-7 cell	-	Growth inhibition assay	-	Inhibition of human HuH-7 cell growth in a cell viability assay, IC50=32.82 nM	SANGER
human HUTU-80 cell	-	Growth inhibition assay	-	Inhibition of human HUTU-80 cell growth in a cell viability assay, IC50=87.01 nM	SANGER
human JAR cell	-	Growth inhibition assay	-	Inhibition of human JAR cell growth in a cell viability assay, IC50=2.6 nM	SANGER
human LoVo cell	-	Growth inhibition assay	-	Inhibition of human LoVo cell growth in a cell viability assay, IC50=0.16093 μM	SANGER
human LXF-289 cell	-	Growth inhibition assay	-	Inhibition of human LXF-289 cell growth in a cell viability assay, IC50=72.85 nM	SANGER
human MC-IXC cell	-	Growth inhibition assay	-	Inhibition of human MC-IXC cell growth in a cell viability assay, IC50=75.33 nM	SANGER
human MDA-MB-231 cell	-	Growth inhibition assay	-	Inhibition of human MDA-MB-231 cell growth in a cell viability assay, IC50=0.10807 μM	SANGER
human MDA-MB-361 cell	-	Growth inhibition assay	-	Inhibition of human MDA-MB-361 cell growth in a cell viability assay, IC50=0.2264 μM	SANGER
human MDA-MB-453 cell	-	Growth inhibition assay	-	Inhibition of human MDA-MB-453 cell growth in a cell viability assay, IC50=0.15188 μM	SANGER
human MG-63 cell	-	Growth inhibition assay	-	Inhibition of human MG-63 cell growth in a cell viability assay, IC50=0.11248 μM	SANGER
human NB14 cell	-	Growth inhibition assay	-	Inhibition of human NB14 cell growth in a cell viability assay, IC50=76.45 nM	SANGER
human NB7 cell	-	Growth inhibition assay	-	Inhibition of human NB7 cell growth in a cell viability assay, IC50=29.28 nM	SANGER
human NCI-H1581 cell	-	Growth inhibition assay	-	Inhibition of human NCI-H1581 cell growth in a cell viability assay, IC50=67.64 nM	SANGER
human NY cell	-	Growth inhibition assay	-	Inhibition of human NY cell growth in a cell viability assay, IC50=0.17762 μM	SANGER
human RKO cell	-	Growth inhibition assay	-	Inhibition of human RKO cell growth in a cell viability assay, IC50=15.17 nM	SANGER
human RPMI-2650 cell	-	Growth inhibition assay	-	Inhibition of human RPMI-2650 cell growth in a cell viability assay, IC50=0.23831 μM	SANGER
human SAS cell	-	Growth inhibition assay	-	Inhibition of human SAS cell growth in a cell viability assay, IC50=33.18 nM	SANGER
human SF126 cell	-	Growth inhibition assay	-	Inhibition of human SF126 cell growth in a cell viability assay, IC50=57.07 nM	SANGER
human SK-MEL-30 cell	-	Growth inhibition assay	-	Inhibition of human SK-MEL-30 cell growth in a cell viability assay, IC50=37.97 nM	SANGER
human SK-MEL-5 cell	-	Growth inhibition assay	-	Inhibition of human SK-MEL-5 cell growth in a cell viability assay, IC50=69.25 nM	SANGER
human SK-UT-1 cell	-	Growth inhibition assay	-	Inhibition of human SK-UT-1 cell growth in a cell viability assay, IC50=28.68 nM	SANGER
human SW1783 cell	-	Growth inhibition assay	-	Inhibition of human SW1783 cell growth in a cell viability assay, IC50=0.21301 μM	SANGER
human SW756 cell	-	Growth inhibition assay	-	Inhibition of human SW756 cell growth in a cell viability assay, IC50=0.11236 μM	SANGER
human SW872 cell	-	Growth inhibition assay	-	Inhibition of human SW872 cell growth in a cell viability assay, IC50=58.9 nM	SANGER
human SW982 cell	-	Growth inhibition assay	-	Inhibition of human SW982 cell growth in a cell viability assay, IC50=0.1107 μM	SANGER
human U-87-MG cell	-	Growth inhibition assay	-	Inhibition of human U-87-MG cell growth in a cell viability assay, IC50=82.24 nM	SANGER
human UACC-62 cell	-	Growth inhibition assay	-	Inhibition of human UACC-62 cell growth in a cell viability assay, IC50=34.35 nM	SANGER
human YH-13 cell	-	Growth inhibition assay	-	Inhibition of human YH-13 cell growth in a cell viability assay, IC50=70.59 nM	SANGER
human YKG-1 cell	-	Growth inhibition assay	-	Inhibition of human YKG-1 cell growth in a cell viability assay, IC50=29.76 nM	SANGER

TW-37 Catalog No. CSN16145

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