|2-丙基戊酰胺|CsnPharm

CAS No.: 2430-27-5

Valpromide/丙戊酰胺 Catalog No. CSN22008

Synonyms: Depamide;Dipropylacetamide;2-propylpentanamide

Valpromide is a carboxamide derivative of valproic acid with anticonvulsant properties and used in the treatment of epilepsy and some affective disorders. It is also a potent inhibitor of liver microsomal epoxide hydrolase.

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技术信息

生物活性

描述Valpromide (VPM), an amide derivative of valproic acid that is not an HDAC (histone deacetylase) inhibitor, prevented expression of two EBV genes, BZLF1 and BRLF1, that mediate lytic reactivation. VPM also inhibited expression of a viral late gene, but not early genes, when BZLF1 was exogenously expressed. VPM selectively inhibits both viral and cellular gene expression^[1]. Valpromide does not induce histone acetylation, does not induce demethylation or expression of CMV-GFP^[2]. VPD (Valpromide) had little effect on limb morphology and no significant effect on HDAC activity or the expression of marker genes^[3]. While both VPA (valproic acid) and sodium butyrate are reported to block sodium channel function as well as HDACs, regeneration was not inhibited by valpromide, an analogue of VPA that lacks HDAC inhibition but retains sodium channel blocking activity^[4]. The HDAC inhibitor trichostatin A (TSA) also inhibited adipogenesis, whereas the VPA analog valpromide, which does not possess HDAC inhibitory effects, did not prevent adipogenesis^[5].
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 6.9818 mL
- 34.9089 mL
- 69.8178 mL
- 5 mM
- 1.3964 mL
- 6.9818 mL
- 13.9636 mL
- 10 mM
- 0.6982 mL
- 3.4909 mL
- 6.9818 mL

技术信息

CAS号

2430-27-5

储存条件

粉末: Sealed in dry,Room Temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C8H17NO

运输

蓝冰

分子量

143.23

别名

Depamide;Dipropylacetamide;2-propylpentanamide;丙戊酰胺;丙丙胺

溶解度

DMSO	28.0 mg/mL (195.5 mM)

动物实验配方

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