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CAS No.: 274901-16-5
Synonyms: LAF237;NVP-LAF 237;DSP-7238
Vildagliptin is an inhibitor of DPP-4 with IC50 of 2.3 nM that is used in the treatment of type 2 diabetes mellitus.
生物活性
靶点 | DPP4 IC50:2.3nM |
NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
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NCT01582308 | Type 2 Diabetes Mellitus | Phase 1 | Completed | - | - |
NCT01582308 | - | - | Completed | - | - |
NCT00099931 | Diabetes Mellitus, Type 2 | Phase 3 | Completed | - | Germany ... more >> Novartis Investigative Site Investigative Sites, Germany Collapse << |
实验方案
技术信息
CAS号 | 274901-16-5 | 储存条件 |
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分子式 | C17H25N3O2 | 运输 | 蓝冰 | |||||||
分子量 | 303.40 | 别名 | LAF237;NVP-LAF 237;DSP-7238;Zomelis;维格列汀;维达列汀 | |||||||
溶解度 |
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动物实验配方 |
Cell Lines | Concentration | Assay Type | Time | Activity Description | Data Sources |
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Caco-2 cells | - | Function assay | - | Inhibition of human DPP4 expressed in Caco-2 cells, Ki=0.004 μM | 17034148 |
insect cells | - | Function assay | - | Inhibition of human recombinant His-tagged DPP4 expressed in insect cells, IC50=0.056 μM | 20718420 |
NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
---|
NCT01582308 | Type 2 Diabetes Mellitus | Phase 1 | Completed | - | - |
NCT01582308 | - | - | Completed | - | - |
NCT00099931 | Diabetes Mellitus, Type 2 | Phase 3 | Completed | - | Germany ... more >> Novartis Investigative Site Investigative Sites, Germany Collapse << |
NCT00396227 | Diabetes Mellitus, Type 2 | Phase 3 | Completed | - | United States, New Jersey ... more >> Novartis Pharmaceuticals East Hanover, New Jersey, United States, 07936 Collapse << |
NCT00351832 | Diabetes Mellitus, Type 2 | Phase 3 | Completed | - | Japan ... more >> Novartis Pharmaceuticals Tokyo, Japan Collapse << |
NCT00099905 | Diabetes Mellitus, Type 2 | Phase 3 | Completed | - | United States, New Jersey ... more >> Novartis Pharmaceuticals East Hanover, New Jersey, United States, 07936 Collapse << |
NCT00101673 | Diabetes Mellitus, Type 2 | Phase 3 | Completed | - | Switzerland ... more >> Novartis Pharmaceuticals Basel, Switzerland Collapse << |
NCT00138567 | Diabetes Mellitus, Type 2 | Phase 3 | Completed | - | United States, New Jersey ... more >> Novartis Investigative Site East Hanover, New Jersey, United States, 07936 Germany Novartis Investigative site Investigative Centers, Germany Collapse << |
NCT00237237 | Diabetes Mellitus, Type 2 | Phase 3 | Completed | - | United States, New Jersey ... more >> Novartis Pharmaceuticals East Hanover, New Jersey, United States, 07936 Germany Investigative Centers Nurnberg, Germany Collapse << |
NCT00494884 | Diabetes Mellitus, Type 2 | Phase 3 | Completed | - | Germany ... more >> Novartis Investigative Site Bochum, Germany Collapse << |
NCT00099944 | Diabetes Mellitus, Type 2 | Phase 3 | Completed | - | United States, New Jersey ... more >> Novartis Pharmaceuticals East Hanover, New Jersey, United States, 07936 Collapse << |
NCT00120536 | Diabetes Mellitus, Type 2 | Phase 3 | Completed | - | United States, New Jersey ... more >> Novartis Pharmaceuticals East Hanover, New Jersey, United States, 07936 Collapse << |
NCT00138619 | Diabetes Mellitus, Type 2 | Phase 3 | Completed | - | United States, New Jersey ... more >> Novartis Pharmaceuticals East Hanover, New Jersey, United States, 07936 Germany Investigative Centers, Germany Collapse << |
NCT00102388 | Diabetes Mellitus, Type 2 | Phase 3 | Completed | - | Germany ... more >> Novartis Investigative Site Investigative Centers, Germany Switzerland Novartis Pharmaceuticals Basel, Switzerland Collapse << |
NCT01757587 | Type 2 Diabetes | Phase 4 | Completed | - | France ... more >> CH Sud Francilien Evry, France, 91000 Collapse << |
NCT00325429 | Diabetes Mellitus, Type 2 | Phase 3 | Completed | - | Japan ... more >> Novartis Pharmaceuticals Tokyo, Japan Collapse << |
NCT00260156 | Diabetes Mellitus, Type 2 | Phase 3 | Completed | - | Switzerland ... more >> Novartis Pharmaceuticals Basel, Switzerland Collapse << |
NCT00138593 | Diabetes Mellitus, Type 2 | Phase 3 | Completed | - | Switzerland ... more >> Novartis Pharmaceuticals Basel, Switzerland Collapse << |
NCT01867502 | Diabetes Mellitus, Type 2 ... more >> Hypoglycemic Agents Diabetic Blood Glucose Monitoring Exercise Collapse << | Phase 4 | Unknown | August 2015 | Brazil ... more >> Hospital de Clínicas de Porto Alegre Porto Alegre Recruiting Porto Alegre, Rio Grande do Sul, Brazil, 90035-903 Contact: Aline Fofonka, MSc 55-5192339191 alinefofonka@hotmail.com Principal Investigator: Beatriz D Schaan, PhD Collapse << |
NCT00419887 | Healthy | Phase 1 | Completed | - | China ... more >> Novartis Beijing, China Collapse << |
NCT01122641 | Insulin Resistance ... more >> Microvascular Disease Collapse << | Phase 3 | Completed | - | United Kingdom ... more >> Diabetes and Vascular Research Department Exeter, Devon, United Kingdom, EX2 5AX Collapse << |
NCT00351507 | Diabetes Mellitus, Type 2 | Phase 3 | Completed | - | United States, Minnesota ... more >> Mayo Clinic Rochester, Minnesota, United States, 55905 Collapse << |
NCT00770081 | Diabetes Mellitus, Type 2 ... more >> Renal Insufficiency Collapse << | Phase 3 | Completed | - | - |
NCT00728351 | Diabetes Mellitus, Type 2 | Phase 3 | Completed | - | - |
NCT00975065 | Type 2 Diabetes Mellitus | Phase 4 | Completed | - | Korea, Republic of ... more >> Handok Pharmaceuticals Seoul, Korea, Republic of Collapse << |
NCT00468039 | Diabetes Mellitus, Type 2 | Phase 3 | Completed | - | United States, Texas ... more >> Diabetes and Glandular Disease Research Associates San Antonio, Texas, United States, 78229 Collapse << |
NCT00821977 | Diabetes Mellitus, Type 2 | Phase 2 Phase 3 | Completed | - | - |
NCT00646542 | Diabetes Mellitus, Type 2 | Phase 3 | Completed | - | Argentina ... more >> Buenos Aires, Argentina Australia Heidelberg Heights, Australia Canada Winnipeg, Canada Costa Rica Cartago, Costa Rica Finland Tampere, Finland France Angers, France Germany Dormagen, Germany India Chennai, India Norway Oslo, Norway Russian Federation Saint Petersburg, Russian Federation Spain Alicante, Spain Sweden Lund, Sweden Collapse << |
NCT01910441 | Type 2 Diabetes Mellitus | Phase 4 | Terminated(The study was termi... more >>nated due to the unavailability of Continuous Glucose Monitoring sensors (CGMS) which were required to assess the primary end-point.) Collapse << | - | - |
NCT00106340 | Diabetes Mellitus, Type 2 | Phase 3 | Completed | - | United States, New Jersey ... more >> Novartis Pharmaceuticals East Hanover, New Jersey, United States, 07936 Germany Investigative Centers Nurnberg, Germany Collapse << |
NCT01910441 | - | - | Terminated(The study was termi... more >>nated due to the unavailability of Continuous Glucose Monitoring sensors (CGMS) which were required to assess the primary end-point.) Collapse << | - | - |
NCT00138580 | Diabetes Mellitus, Type 2 | Phase 3 | Completed | - | United States, New Jersey ... more >> Novartis Pharmaceuticals East Hanover, New Jersey, United States, 07936 Collapse << |
NCT00138515 | Diabetes Mellitus, Type 2 | Phase 3 | Completed | - | United States, New Jersey ... more >> Novartis Pharmaceuticals East Hanover, New Jersey, United States, 07936 Collapse << |
NCT03253562 | Reducing the Elevated Blood Pr... more >>essure for Diabetic Hypertensive Patients Collapse << | Phase 4 | Completed | - | Egypt ... more >> National institute of diabetes and endocrinology Cairo, Egypt, 11311 Collapse << |
NCT03088670 | Diabetes Mellitus, Type 2 | Phase 3 | Completed | - | Russian Federation ... more >> Non-state healthcare Organization "Road Clinical Hospital at the station Chelyabinsk Open Joint Stock Company" Russian Railways Chelyabinsk, Russian Federation, 454048 State Budget Healthcare Institution of Moscow "Endocrinology Dispensary" Moscow, Russian Federation, 119034 SEI HPE "First Moscow State Medical University n.a. I.M. Sechenov of Ministry of Health and Social Development of the Russian Federation", Chair of faculty therapy #2 based at SHI of Moscow "City clinical hospital #61" Moscow, Russian Federation, 119048 State Budget Educational Institution higher professional education "1st Moscow State Medical University n.a. I.M. Sechenov of the Ministry of Healthcare of Russian Federation" Moscow, Russian Federation, 119435 Federal State Institution "Clinical Hospital № 1" of the Office of the President of the Russian Federation Moscow, Russian Federation, 121352 State Budget Healthcare Institution of Moscow city "City Clinical Hospital # 71 by the Department of Healthcare in Moscow" Moscow, Russian Federation, 121374 State Budget Educational Institution of higher professional education "1st Moscow State Medical University n.a. I.M. Sechenov of the Ministry of Healthcare of Russian Federation" based on Endocrinology department of Hospital № 67 n.a L A Vorohobova Moscow, Russian Federation, 123423 SEI APE "Russian Medical Academy of Postgraduate Education of Roszdrav", Chair of endocrinology and diabetology with course of endocrine surgery based at FSI "Central Clinical hospital of civil aviation" Moscow, Russian Federation, 125367 State budgetary institution "Nizhny Novgorod Regional Clinical Hospital n.a Semashko Nizhny Novgorod, Russian Federation, 603126 State Health Care Institution "Perm Regional Hospital for War Veterans" Perm, Russian Federation, 614097 State Educational Institution of Higher Professional Education "Perm State Medical Academy n.a. academician EA Wagner's "Ministry of Health of the Russian Federation on the basis of Department of Endocrinology Regional Clinical Hospital Perm, Russian Federation, 614990 SHI "Republic Hospital n.a. V.A. Baranov" Petrozavodsk, Russian Federation, 185019 State budgetary institution of Ryazan region "City Clinical Hospital № 11" Ryazan, Russian Federation, 390037 St. Petersburg State healthcare institution "City Outpatient Clinic #37" Saint Petersburg, Russian Federation, 191119 FSHI "Clinical Hospital #122 n.a. L.G. Sokolov of FMBA of Russia", Internal medicine department Saint Petersburg, Russian Federation, 194291 State Health Care Institution Leningrad Regional Hospital Saint Petersburg, Russian Federation, 194291 Autonomous Noncommercial Organization "Medical Centre "XXI сentury" Saint Petersburg, Russian Federation, 194354 St. Petersburg State healthcare institution "City Hospital of Saint Martyr Elizaveta" Saint Petersburg, Russian Federation, 195257 FSMEI HPE "Military Medical Academy n.a. S.M. Kirov" of the Ministry of Defence of the Russian Federation, 1st Internal medicine Chair of advanced training Saint Petersburg, Russian Federation, 198013 "Diabetes Center "LLC Samara, Russian Federation, 443041 State Budget Educational Institution higher professional education "Saratov State Medical University n.a. V.I. Razumovsky" of the Ministry of Healthcare of Russian Federation based on Clinical Hospital n.a S.R. Mirotvortsev Saratov, Russian Federation, , 410054 Municipal health care institution "City polyclinic №20 Saratov, Russian Federation, 410018 SBEI HPE "Smolensk State Medical Academy" of the Ministry of Health and Social Development of the Russian Federation, Center of clinical research of diagnostic and medicinal products, Chair of clinical pharmacology Smolensk, Russian Federation, 214019 State budget educational institution of higher education "Smolensk State Medical Academy," of Ministry of Health and Social Development of the Russian Federation on the basis of sanatorium SSMA Smolensk, Russian Federation, 214019 State autonomous healthcare institution of Yaroslavl Region "Сlinical hospital for emergency medical care n. a. N.V. Solovyov" Yaroslavl, Russian Federation, 150003 Municipal clinical health institution Health Service Novo-Yaroslavl Oil Refinery Yaroslavl, Russian Federation, 150023 SHI of Yaroslavl region "Regional Clinical Hospital", Endocrinology department Yaroslavl, Russian Federation, 150062 Collapse << |
NCT00138606 | Diabetes Mellitus, Type 2 | Phase 3 | Completed | - | United States, New Jersey ... more >> Novartis Pharmaceuticals East Hanover, New Jersey, United States, 07936 Germany Novartis Investigative Site Investigative Centers, Germany Collapse << |
NCT00414947 | Healthy | Phase 1 | Completed | - | China ... more >> Novartis Investigative Site Beijing, China Collapse << |
NCT01862263 | Type 2 Diabetes Mellitus | Phase 4 | Completed | - | Mexico ... more >> Novartis Investigative Site Mexico, Distrito Federal, Mexico, 06700 Novartis Investigative Site Mexico, Distrito Federal, Mexico, 07300 Novartis Investigative Site Mexico, Distrito Federal, Mexico, 14050 Novartis Investigative Site Metepec, Estado de México, Mexico, 52140 Novartis Investigative Site Celaya, Guanajuato, Mexico, 38000 Novartis Investigative Site Guadalajara, Jalisco, Mexico, 44150 Novartis Investigative Site Guadalajara, Jalisco, Mexico, 44600 Novartis Investigative Site Guadalajara, Jalisco, Mexico, 44670 Novartis Investigative Site Monterrey, Nuevo Leon, Mexico, 64710 Novartis Investigative Site Monterrey, Nuevo León, Mexico, 64020 Novartis Investigative Site Cancun, Quintana Roo, Mexico, 77500 Novartis Investigative Site Culiacán, Sinaloa, Mexico, 80000 Novartis Investigative Site Puebla, Mexico, 72190 Collapse << |
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NCT00351884 | Diabetes Mellitus, Type 2 | Phase 3 | Completed | - | United States, New Jersey ... more >> Novartis Pharmaceuticals East Hanover, New Jersey, United States, 07936 Germany Novartis Investigative Site Investigative Centers, Germany Collapse << |
NCT01565096 | Diabetes Mellitus Type II | Phase 4 | Unknown | - | Germany ... more >> ikfe GmbH Recruiting Mainz, Germany, 55116 Contact: Thomas Forst, Prof., MD +49 6131 576 36 16 thomasf@ikfe.de Contact: Swantje Anders +49 6131 327 90 22 s.anders@ikfe-cro.de Collapse << |
NCT00099866 | Diabetes Mellitus, Type 2 | Phase 3 | Completed | - | Germany ... more >> Novartis investigative Site Investigative Sites, Germany Collapse << |
NCT00138541 | Diabetes Mellitus, Type 2 | Phase 3 | Completed | - | United States, New Jersey ... more >> Novartis Pharmaceuticals East Hanover, New Jersey, United States, 07936 Collapse << |
NCT00380380 | Diabetes Mellitus, Type 2 | Phase 3 | Completed | - | Germany ... more >> Munich, 81377, Germany Munich, Germany Collapse << |
NCT01356381 | Type 2 Diabetes Mellitus | Phase 4 | Completed | - | United Kingdom ... more >> Novartis Investigative Site Newcastle Upon Tyne, United Kingdom, NE4 5PL Collapse << |
NCT02007278 | Type 2 Diabetes ... more >> Hypoglycemia Collapse << | Phase 4 | Completed | - | Colombia ... more >> Novartis Investigative Site Medellín, Antioquia, Colombia Novartis Investigative Site Manizales, Caldas, Colombia, 1700 Novartis Investigative Site Bogotá, Cundinamarca, Colombia Novartis Investigative Site Chía, Cundinamarca, Colombia, 11001000 Novartis Investigative Site Cali, Valle del Cauca, Colombia, 760001 Novartis Investigative Site Bogotá, Colombia, 00000 Novartis Investigative Site Cali, Colombia Novartis Investigative Site Monteria, Colombia Collapse << |
NCT00616811 | Diabetes Mellitus, Type 2 | Phase 3 | Completed | - | - |
NCT01604213 | Type 2 Diabetes Mellitus ... more >> Ischemic Heart Disease Collapse << | Phase 4 | Completed | - | Israel ... more >> Sheba Medical Center, Cardiac Rehabilitation Institute Tel Hashomer, Israel, 52621 Collapse << |
NCT01649466 | Type 2 Diabetes Mellitus | Phase 4 | Completed | - | - |
NCT02999841 | Diabetes Mellitus, Type 2 ... more >> Obesity Collapse << | Phase 4 | Unknown | January 2018 | China, Beijing ... more >> Beijing Pinggu Hospital Recruiting Beijing, Beijing, China, 101200 Contact: Yufeng Li, MD +86 139 1108 0328 Principal Investigator: Yufeng Li, MD Collapse << |
NCT00396071 | Diabetes Mellitus, Type 2 | Phase 3 | Completed | - | Germany ... more >> Diabetes Zentrum Bad Lauterberg Bad Lauterberg, Germany, 37431 Switzerland Novartis Pharmaceuticals Basel, Switzerland Collapse << |
NCT00765830 | Diabetes Mellitus, Type 2 ... more >> Renal Insufficiency Collapse << | Phase 3 | Completed | - | - |
NCT00567047 | Type-2 Diabetes | Phase 1 | Completed | - | United States, Florida ... more >> Novartis Investigator Site Miami, Florida, United States, 33136 Novartis Investigator Site Orlando, Florida, United States, 32809 United States, Minnesota Novartis Investigator Site Minneapolis, Minnesota, United States, 55404 United States, Tennessee Novartis Investigator Site Knoxville, Tennessee, United States, 37920 United States, Virginia Novartis Investigator Site Richmond, Virginia, United States, 23298 Germany Novartis Investigator Site Kiel, Germany Collapse << |
NCT00101712 | Diabetes Mellitus, Type 2 | Phase 3 | Completed | - | Germany ... more >> Novartis Investigative Site Investigative Site, Germany Switzerland Novartis Investigative Site Basel, Switzerland Collapse << |
NCT02007278 | - | - | Completed | - | - |
NCT00099853 | Diabetes Mellitus, Type 2 | Phase 3 | Completed | - | United States, New Jersey ... more >> Novartis Pharmaceuticals East Hanover, New Jersey, United States, 07936 Collapse << |
NCT00138554 | Diabetes Mellitus, Type 2 | Phase 3 | Completed | - | United States, New Jersey ... more >> Novartis Pharmaceuticals East Hanover, New Jersey, United States, 07936 Collapse << |
NCT00818571 | Renal Impairment ... more >> Diabetes Collapse << | Phase 1 Phase 2 | Completed | - | Russian Federation ... more >> Novartis Investigator Site Moscow, Russian Federation Collapse << |
NCT02343926 | Type 2 Diabetes Mellitus | Phase 3 | Completed | - | Russian Federation ... more >> Investigational Site 03 Vladimir, Vladimirskaya Oblast, Russian Federation, 600023 Collapse << |
NCT01357252 | Type 2 Diabetes Mellitus | Phase 3 | Completed | - | China, Beijing ... more >> Novartis Investigative Site Beijing, Beijing, China, 100088 China, Hebei Novartis Investigative Site Shijiazhuang, Hebei, China, 050051 China, Hubei Novartis Investigative Site Wuhan, Hubei, China, 430070 China, Hunan Novartis Investigative Site Changsha, Hunan, China, 410003 China, Jiangsu Novartis Investigative Site Nanjing, Jiangsu, China, 210006 Novartis Investigative Site Nanjing, Jiangsu, China, 210008 Novartis Investigative Site Nanjing, Jiangsu, China, 210029 Novartis Investigative Site Zhenjiang, Jiangsu, China, 212001 China, Liaoning Novartis Investigative Site ShenYang, Liaoning, China, 110003 China, Shanghai Novartis Investigative Site Shanghai, Shanghai, China China, Tianjin Novartis Investigative Site Tianjin, Tianjin, China, 300211 China Novartis Investigative Site Beijing, China, 100029 Novartis Investigative Site Beijing, China, 100034 Novartis Investigative Site Beijing, China, 100730 Novartis Investigative Site Beijing, China Novartis Investigative Site Guang zhou, China, 510080 Novartis Investigative Site Shanghai, China, 200040 Novartis Investigative Site Shanghai, China, 200233 Collapse << |
NCT01159249 | Type 2 Diabetes | Phase 3 | Completed | - | Japan ... more >> Novartis Investigative Site Hunabashi, Chiba, Japan, 274-0805 Novartis Investigative Site Chikushino, Fukuoka, Japan, 818-0036 Novartis Investigative Site Itoshima-shi, Fukuoka, Japan, 819-1102 Novartis Investigative Site Koriyama, Fukushima, Japan, 963-8851 Novartis Investigative Site Kobe, Hyogo, Japan, 658-0064 Novartis Investigative Site Kawasaki, Kanagawa, Japan, 210-0852 Novartis Investigative Site Kawasaki, Kanagawa, Japan, 212-0024 Novartis Investigative Site Yokohama-city, Kanagawa, Japan, 221-0077 Novartis Investigative Site Yokohama, Kanagawa, Japan, 221-0065 Novartis Investigative Site Izumisano, Osaka, Japan, 598-0048 Novartis Investigative Site Hannou, Saitama, Japan, 357-0024 Novartis Investigative Site Hiki-Gun, Saitama, Japan, 355-0328 Novartis Investigative Site Kawaguchi, Saitama, Japan, 332-0012 Novartis Investigative Site Koshigaya city, Saitama, Japan, 343-0826 Novartis Investigative Site Tokorozawa, Saitama, Japan, 359-1161 Novartis Investigative Site Edogawa-ku, Tokyo, Japan, 134-0084 Novartis Investigative Site Hachioji, Tokyo, Japan, 192-0046 Novartis Investigative Site Katsushika-ku, Tokyo, Japan, 125-0041 Novartis Investigative Site Minato-ku, Tokyo, Japan, 108-0075 Novartis Investigative Site Shinagawa-ku, Tokyo, Japan, 141-0032 Novartis Investigative Site Toshima-ku, Tokyo, Japan, 171-0021 Novartis Investigative Site Fukuoka, Japan, 807-0857 Novartis Investigative Site Fukuoka, Japan, 816-0094 Novartis Investigative Site Fukuoka, Japan, 819-0168 Collapse << |
NCT01679899 | Type 2 Diabetes Mellitus ... more >> Menopause Osteoporosis Osteopenia Collapse << | Phase 4 | Completed | - | Brazil ... more >> Centro de Diabetes Curitiba Curitiba, Parana, Brazil, 80810040 Collapse << |
NCT01703637 | Type 2 Diabetes Mellitus | Not Applicable | Unknown | - | China, Shandong ... more >> YuCheng people's hospital Recruiting Dezhou, Shandong, China, 253000 Contact: Pengfei Li lpf9669@163.com Hospital of SINOTRUK Recruiting Jinan, Shandong, China, 250010 Contact: Xiling Fu fxl1936@163.com Jinan central hospital Recruiting Jinan, Shandong, China, 250010 Contact: Shuguang Pang shuguangpang@163.com The jinan military region general hospital Recruiting Jinan, Shandong, China, 250010 Contact: Zhaoshun Jiang zhaoshunjiang@sohu.com Qianfoshan Hospital Recruiting Jinan, Shandong, China, 250012 Contact: Lin Liao, MD 8615168888260 liaolin@medmail.com.cn People's Hospital of Qingdao Chengyang Recruiting Qingdao, Shandong, China, 266100 Contact: Xiaopang Rao 123raoxiaopang@163.com Zibo central hospital Recruiting Zibo, Shandong, China, 255000 Contact: Xiaodong Zhao 19xiaodong@163.com Zibo eighth people's hospital Recruiting Zibo, Shandong, China, 255000 Contact: Ling Dai +86 13853388549 Collapse << |
NCT01404676 | Type 2 Diabetes Mellitus | Phase 4 | Completed | - | Korea, Republic of ... more >> Division of Endocrinology and Metabolism, Department of Internal Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine Seoul, Korea, Republic of, 135-710 Collapse << |
NCT01000688 | Type 2 Diabetes ... more >> Endothelial Dysfunction Collapse << | Phase 3 | Completed | - | Netherlands ... more >> Radboud University Nijmegen Medical Centre Nijmegen, Netherlands, 6500 HB Collapse << |
NCT01196546 | Type 2 Diabetes Mellitus | Phase 4 | Completed | - | Thailand ... more >> BMA Medical College and Vajira Hospital Bangkok, Thailand King Chulalongkorn Memorial Hospital Bangkok, Thailand Phamongkutklao Hospital Bangkok, Thailand Police General Hospital Bangkok, Thailand Siriraj Hospital Bangkok, Thailand Khon Kaen Hospital Khon Kaen, Thailand Fort Suranaree Hospital Nakhon Ratchasima, Thailand Maharat Nakhon Ratchasima Hospital Nakhon Ratchasima, Thailand Collapse << |
NCT01262586 | Type II Diabetes Mellitus | Phase 3 | Completed | - | Germany ... more >> Novartis Investigative Site Mainz, Germany Collapse << |
NCT00380445 | Diabetes Mellitus, Type 2 | Phase 3 | Completed | - | United States, New Jersey ... more >> Novartis Pharmaceuticals East Hanover, New Jersey, United States, 07936 Germany Novartis Investigative Site Investigative Centers, Germany Collapse << |
NCT01871558 | Type 2 Diabetes Mellitus (T2DM... more >>) Collapse << | Phase 3 | Completed | - | France ... more >> Novartis Investigative Site Antibes, France, 06600 Novartis Investigative Site Auxerre, France, 89000 Novartis Investigative Site Bar le Duc, France, 55012 Novartis Investigative Site Bondy, France, 93143 Novartis Investigative Site Brest, France, 29200 Novartis Investigative Site Caen, France, 14000 Novartis Investigative Site Corbeil Essonnes, France, 91100 Novartis Investigative Site Fleury sur Orne, France, 14123 Novartis Investigative Site Maisons Laffitte, France, 78600 Novartis Investigative Site Menton, France, 06500 Novartis Investigative Site Montpellier, France, 34090 Novartis Investigative Site Paris, France, 75010 Novartis Investigative Site Rennes, France, 35203 Novartis Investigative Site Saint Nazaire, France, 44600 Novartis Investigative Site Sanary Sur Mer, France, 83110 Novartis Investigative Site Strsbourg, France, 67000 Novartis Investigative Site Toulouse, France, 31300 Novartis Investigative Site Valence, France, 26000 Novartis Investigative Site Valenciennes, France, 59300 Collapse << |
NCT03563794 | T2DM | Phase 4 | Recruiting | December 10, 2019 | China, Fujian ... more >> The first afilliated hospital of Xiamen university Recruiting Xiamen, Fujian, China, 361003 Contact: Xue-jun Li, MD,PHD 13860451316 lixuejue99@yahoo.com.cn Principal Investigator: Xue-jun Li, MD,PhD Collapse << |
NCT03693560 | Coronary Artery Disease ... more >> Diabetes Mellitus, Type 2 Collapse << | Phase 4 | Active, not recruiting | February 2019 | Egypt ... more >> Faculty of Pharmacy - Damanhour University. Damanhūr, Egypt Collapse << |
NCT00894868 | Congestive Heart Failure ... more >> Type II Diabetes Mellitus Collapse << | Phase 4 | Completed | - | - |
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NCT00936234 | SDF-1 is an Important Cytokine... more >> for Neovascularization. Cleavage of SDF-1 is Reduced by DPPIV Inhibitors Collapse << | Phase 2 Phase 3 | Unknown | November 2012 | Germany ... more >> Department of Cardiology Recruiting Frankfurt, Germany, 60590 Contact: Florian H Seeger, MD 0049 69 6301 7343 Sub-Investigator: Florian H Seeger, MD Collapse << |
NCT02849899 | Disorder Related to Renal Tran... more >>splantation Diabetes Collapse << | Phase 3 | Not yet recruiting | January 2020 | - |
NCT01766778 | - | - | Completed | - | - |
NCT01758380 | Type 2 Diabetes Mellitus | Phase 4 | Completed | - | - |
NCT01766778 | Type-2 Diabetes Mellitus | Phase 4 | Completed | - | Hong Kong ... more >> Novartis Investigative Site Hong Kong SAR, Hong Kong Novartis Investigative Site HongKong, Hong Kong Novartis Investigative Site Tuen Mun, Hong Kong Collapse << |
NCT01528254 | Type 2 Diabetes Mellitus | Phase 4 | Active, not recruiting | April 18, 2019 | - |
NCT01559025 | Type 1 Diabetes ... more >> Insulin Dependent Diabetes Juvenile Onset Diabetes Mellitus Autoimmune Diabetes Collapse << | Phase 3 | Unknown | March 2017 | Brazil ... more >> Federal University of São Paulo Recruiting São Paulo, Brazil, 04022-001 Contact: Tatiana Valente 55119614616 valentetati@yahoo.com.br Contact: Sergio Dib 551197397776 sergio.dib@unifesp.br Sub-Investigator: Monica Gabbay Collapse << |
NCT00980356 | Diabetes Mellitus | Phase 2 | Completed | - | Austria ... more >> Medical University of Vienna Vienna, Austria, 1090 Collapse << |
NCT03500900 | Healthy | Not Applicable | Completed | - | - |
NCT01822548 | Type 2 Diabetes | Phase 3 | Completed | - | Italy ... more >> Azienda Opedaliera-Universitaria Parma, Italy, 43126 Azienda Ospedaliera-Universitaria Parma, Italy, 43126 Collapse << |
NCT01257451 | Type 2 Diabetes Mellitus | Phase 3 | Completed | - | - |
NCT01822548 | - | - | Completed | - | - |
NCT02853630 | TYpe 2 Diabetes Mellitus | Phase 4 | Active, not recruiting | December 2018 | India ... more >> Jnana Sanjeevini Medical Centre Bangalore, Karnataka, India, 560 078 Vikas Pai Research Foundation Pune, Maharashtra, India, 411 005 Singhvi Health Centre Chennai, Tamil Nadu, India, 600 019 Dr V.Seshiah Diabetes research Institute, Dr V.Balaji Diabetes care centre Chennai, Tamil Nadu, India, 600029 Arthur Asirvatham Hospital Madurai, Tamil Nadu, India, 625 020 Ramana Maharishi Rangammal Hospital Tiruvannamalai, Tamil Nadu, India, 606 603 Collapse << |
NCT01147276 | Diabetes Hypo... more >>glycemia Collapse << | Phase 4 | Completed | - | Sweden ... more >> Department of Clinical Sciences Lund, Lund University Lund, Sweden, 221 84 Collapse << |
NCT01398592 | Diabetes Mellitus Type 2 | Phase 4 | Completed | - | Germany ... more >> Novartis Investigative Site Bad Oeynhausen, Germany, 32549 Novartis Investigative Site Berlin, Germany, 12347 Novartis Investigative Site Berlin, Germany, 13597 Novartis Investigative Site Berlin, Germany, 14089 Novartis Investigative Site Celle, Germany, 29221 Novartis Investigative Site Hannover, Germany, 30165 Novartis Investigative Site Hannover, Germany, 30167 Novartis Investigative Site Kassel, Germany, 34117 Novartis Investigative Site Kirchhain, Germany, 35274 Novartis Investigative Site Lehrte, Germany, 31275 Novartis Investigative Site Mülheim, Germany, 45468 Novartis Investigative Site Oberhausen, Germany, 46049 Novartis Investigative Site Osnabrück, Germany, 49080 Novartis Investigative Site Potsdam, Germany, 14469 Novartis Investigative Site Stuttgart, Germany, 70378 Collapse << |
NCT01219400 | Diabetes | Phase 4 | Completed | - | Sweden ... more >> Lund University Lund, Sweden, 22184 Collapse << |
NCT02816970 | Healthy | Phase 1 | Completed | - | Egypt ... more >> Genuine Research Center GRC Cairo, Egypt, 11757 Collapse << |
NCT01582230 | Type 2 Diabetes Mellitus | Phase 3 | Completed | - | China, Beijing ... more >> Novartis Investigative Site Beijing, Beijing, China, 100730 China, Hunan Novartis Investigative Site Changsha City, Hunan, China, 410011 Novartis Investigative Site Changsha, Hunan, China, 410003 China, Jiangsu Novartis Investigative Site Nanjing, Jiangsu, China, 210006 Novartis Investigative Site Wu Xi, Jiangsu, China, 214023 China, Jiangxi Novartis Investigative Site Nanchang, Jiangxi, China, 330006 China, Liaoning Novartis Investigative Site Shenyang, Liaoning, China, 110003 China, Shandong Novartis Investigative Site Jinan, Shandong, China, 250031 China, Shanxi Novartis Investigative Site Xi'an, Shanxi, China, 710032 China, Sichuan Novartis Investigative Site Chengdu, Sichuan, China, 610072 China Novartis Investigative Site Beijing, China Novartis Investigative Site Shanghai, China, 200025 Novartis Investigative Site Tianjin, China, 300052 Philippines Novartis Investigative Site Metro Manila, Philippines, 1500 Novartis Investigative Site Pasay City, Philippines, 1300 Novartis Investigative Site Quezon City, Philippines, 1102 Singapore Novartis Investigative Site Singapore, Singapore, 169608 Novartis Investigative Site Singapore, Singapore, 768825 Thailand Novartis Investigative Site Bangkok, Thailand, 10330 Novartis Investigative Site Bangkok, Thailand, 10400 Novartis Investigative Site Khon Kaen, Thailand, 40002 Collapse << |
NCT02475070 | Type 2 Diabetes | Phase 4 | Completed | - | Sweden ... more >> Lund University Lund, Sweden, 22184 Collapse << |
NCT02145611 | Type 2 Diabetes Mellitus ... more >> Hypertension Endothelial Dysfunction Collapse << | Phase 4 | Completed | - | Brazil ... more >> Fundação Faculdade Regional de Medicina de São José do Rio Preto São José do Rio Preto, São Paulo, Brazil, 15090-000 Collapse << |
NCT01827280 | 1- Microvascular Function ... more >> 2-oxidative Stress 3-inflammation Collapse << | Phase 4 | Completed | - | Brazil ... more >> Laboratory for Clinical and Experimental Research on Vascular Biology Rio de Janeiro, Brazil, 20550-900 Collapse << |
NCT01426802 | Type 2 Diabetes Mellitus | Phase 4 | Completed | - | Egypt ... more >> Investigative site Cairo, Egypt Collapse << |
NCT01582243 | Diabetes Mellitus, Type 2 | Phase 4 | Completed | - | Taiwan ... more >> Novartis Investigative Site Changhua, Taiwan, 500 Collapse << |
NCT01497522 | Diabetes Mellitus, Type 2 | Phase 3 | Completed | - | Japan ... more >> Novartis Investigative Site Kitakyushu, Fukuoka, Japan, 800-0296 Novartis Investigative Site Kurume, Fukuoka, Japan, 830-8543 Novartis Investigative Site Ohkawa-city, Fukuoka, Japan, 831-0016 Novartis Investigative Site Kawasaki-city, Kanagawa, Japan, 210-0014 Novartis Investigative Site Yokohama, Kanagawa, Japan, 221-0802 Novartis Investigative Site Kyoto-city, Kyoto, Japan, 615-0035 Novartis Investigative Site Takatsuki, Osaka, Japan, 569-1096 Novartis Investigative Site Ageo-city, Saitama, Japan, 362-8588 Novartis Investigative Site Bunkyo-ku, Tokyo, Japan, 113-0031 Novartis Investigative Site Edogawa-ku, Tokyo, Japan, 134-0084 Novartis Investigative Site Hachioji, Tokyo, Japan, 192-0046 Novartis Investigative Site Kiyose, Tokyo, Japan, 204-0021 Novartis Investigative Site Minato-ku, Tokyo, Japan, 105-7390 Novartis Investigative Site Minato-ku, Tokyo, Japan, 108-0075 Novartis Investigative Site Nerima-ku, Tokyo, Japan, 177-0051 Novartis Investigative Site Shinagawa-ku, Tokyo, Japan, 141-0032 Novartis Investigative Site Toshima-ku, Tokyo, Japan, 171-0021 Novartis Investigative Site Fukuoka, Japan, 810-0001 Novartis Investigative Site Fukuoka, Japan, 819-0168 Novartis Investigative Site Kyoto, Japan, 607-8062 Collapse << |
NCT01541956 | Type 2 Diabetes | Phase 4 | Completed | - | China ... more >> Novartis Investigative Site Beijing, China, 100028 Collapse << |
NCT01686932 | - | - | Completed | - | - |
NCT01686932 | Diabetes Mellitus Type 2 | Phase 4 | Completed | - | Germany ... more >> Novartis Investigative Site Berlin, Germany, 10115 Novartis Investigative Site Berlin, Germany, 13055 Novartis Investigative Site Dortmund, Germany, 44137 Novartis Investigative Site Dresden, Germany, 01307 Novartis Investigative Site Elsterwerda, Germany, 04910 Novartis Investigative Site Falkensee, Germany, 14612 Novartis Investigative Site Magdeburg, Germany, 39112 Novartis Investigative Site Neuss, Germany, 41460 Novartis Investigative Site Potsdam, Germany, 14469 Novartis Investigative Site Sulzbach-Rosenberg, Germany, 92237 Novartis Investigative Site Wallerfing, Germany, 94574 Collapse << |
NCT03577184 | - | - | Not yet recruiting | March 2019 | - |
NCT01882907 | Type 2 Diabetes | Phase 4 | Completed | - | Korea, Republic of ... more >> Busan Saint Mary's Medical Center Busan, Korea, Republic of Dong-AUniversity Medical Center Busan, Korea, Republic of Inje University Baik Hospital Busan, Korea, Republic of Kosin University Hospital Busan, Korea, Republic of Pusan National University Hospital Busan, Korea, Republic of Changwon Fatima Hospital Changwon, Korea, Republic of Daegu Catholic University Medical Center Daegu, Korea, Republic of Keimyung University Dongsan Medical Center Daegu, Korea, Republic of Kyungbuk National Universtiy Hospital Daegu, Korea, Republic of Chonnam National University Hospital Gwangju, Korea, Republic of Chosun University Hospital Gwangju, Korea, Republic of Chonbuk National University Hospital Jeonju, Korea, Republic of Gyeongsang National University Hospital Jinju, Korea, Republic of Masan Samsung Medical Center Masan, Korea, Republic of Ulsan University Hospital Ulsan, Korea, Republic of Collapse << |
NCT01882907 | - | - | Completed | - | - |
NCT01582243 | - | - | Completed | - | - |
靶点 | Description | IC50 |
---|---|---|
DPP4 | IC50:2.3nM |
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