|(2,4-二甲氧基苯基)(2-((4-(4-甲基哌嗪-1-基)苯基)氨基)嘧啶-4-基)氨基甲酸-2,6-二甲基苯酯|CsnPharm

CAS No.: 837422-57-8

WH-4-023 Catalog No. CSN16229

Synonyms: Dual LCK/SRC inhibitor;KIN-001112;KIN-112

WH-4-023 is an inhibitor of Lck and Src with IC50 of 2 nM, 6 nM, respectively.

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400-920-2911

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靶点选择性

生物活性

实验方案

技术信息

生物活性

靶点 Lck

IC50:2nM Src

IC50:6nM
描述WH-4-023 is a potent and selective dual Lck/Src inhibitor with IC50 of 2 nM/6 nM for Lck and Src kinase respectively, and shows little inhibition on p38α and KDR.
细胞研究

Cell Data

Cell Lines	Concentration	Assay Type	Time	Activity Description	Data Sources
A498 cell	-	Growth inhibition assay	-	Inhibition of human A498 cell growth in a cell viability assay, IC50=0.18945 μM	SANGER
COLO-829 cell	-	Growth inhibition assay	-	Inhibition of human COLO-829 cell growth in a cell viability assay, IC50=0.31212 μM	SANGER
human A388 cell	-	Growth inhibition assay	-	Inhibition of human A388 cell growth in a cell viability assay, IC50=14.6758 μM	SANGER

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 1.7585 mL
- 8.7925 mL
- 17.5850 mL
- 5 mM
- 0.3517 mL
- 1.7585 mL
- 3.5170 mL
- 10 mM
- 0.1759 mL
- 0.8793 mL
- 1.7585 mL

技术信息

CAS号

837422-57-8

储存条件

粉末: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C32H36N6O4

运输

蓝冰

分子量

568.67

别名

Dual LCK/SRC inhibitor;KIN-001112;KIN-112

溶解度

DMSO	12.0 mg/mL (21.1 mM) warming
Water	Insoluble
Ethanol	6.0 mg/mL (10.6 mM) warming

动物实验配方

5% DMSO+30% PEG 300+5% Tween 80+water

1 mg/mL

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Cell Lines	Concentration	Assay Type	Time	Activity Description	Data Sources

A498 cell	-	Growth inhibition assay	-	Inhibition of human A498 cell growth in a cell viability assay, IC50=0.18945 μM	SANGER
COLO-829 cell	-	Growth inhibition assay	-	Inhibition of human COLO-829 cell growth in a cell viability assay, IC50=0.31212 μM	SANGER
human A388 cell	-	Growth inhibition assay	-	Inhibition of human A388 cell growth in a cell viability assay, IC50=14.6758 μM	SANGER
human A704 cell	-	Growth inhibition assay	-	Inhibition of human A704 cell growth in a cell viability assay, IC50=0.00127 μM	SANGER
human BB30-HNC cell	-	Growth inhibition assay	-	Inhibition of human BB30-HNC cell growth in a cell viability assay, IC50=1.85472 μM	SANGER
human Becker cell	-	Growth inhibition assay	-	Inhibition of human Becker cell growth in a cell viability assay, IC50=0.06381 μM	SANGER
human BL-41 cell	-	Growth inhibition assay	-	Inhibition of human BL-41 cell growth in a cell viability assay, IC50=1.00013 μM	SANGER
human BL-70 cell	-	Growth inhibition assay	-	Inhibition of human BL-70 cell growth in a cell viability assay, IC50=4.72e-05 μM	SANGER
human BOKU cell	-	Growth inhibition assay	-	Inhibition of human BOKU cell growth in a cell viability assay, IC50=1.80527 μM	SANGER
human BV-173 cell	-	Growth inhibition assay	-	Inhibition of human BV-173 cell growth in a cell viability assay, IC50=0.000514 μM	SANGER
human CTV-1 cell	-	Growth inhibition assay	-	Inhibition of human CTV-1 cell growth in a cell viability assay, IC50=3.18e-05 μM	SANGER
human D-263MG cell	-	Growth inhibition assay	-	Inhibition of human D-263MG cell growth in a cell viability assay, IC50=2.28853 μM	SANGER
human D-336MG cell	-	Growth inhibition assay	-	Inhibition of human D-336MG cell growth in a cell viability assay, IC50=0.04681 μM	SANGER
human Daudi cell	-	Growth inhibition assay	-	Inhibition of human Daudi cell growth in a cell viability assay, IC50=0.71411 μM	SANGER
human DMS-114 cell	-	Growth inhibition assay	-	Inhibition of human DMS-114 cell growth in a cell viability assay, IC50=2.79022 μM	SANGER
human DOHH-2 cell	-	Growth inhibition assay	-	Inhibition of human DOHH-2 cell growth in a cell viability assay, IC50=0.000597 μM	SANGER
human EM-2 cell	-	Growth inhibition assay	-	Inhibition of human EM-2 cell growth in a cell viability assay, IC50=3.91e-08 μM	SANGER
human EoL-1-cell cell	-	Growth inhibition assay	-	Inhibition of human EoL-1-cell cell growth in a cell viability assay, IC50=9.51e-06 μM	SANGER
human ES6 cell	-	Growth inhibition assay	-	Inhibition of human ES6 cell growth in a cell viability assay, IC50=2.05401 μM	SANGER
human GB-1 cell	-	Growth inhibition assay	-	Inhibition of human GB-1 cell growth in a cell viability assay, IC50=1.16064 μM	SANGER
human GCIY cell	-	Growth inhibition assay	-	Inhibition of human GCIY cell growth in a cell viability assay, IC50=1.2301 μM	SANGER
human HOP-62 cell	-	Growth inhibition assay	-	Inhibition of human HOP-62 cell growth in a cell viability assay, IC50=0.91599 μM	SANGER
human HT-144 cell	-	Growth inhibition assay	-	Inhibition of human HT-144 cell growth in a cell viability assay, IC50=1.44517 Μm	SANGER
human IST-SL2 cell	-	Growth inhibition assay	-	Inhibition of human IST-SL2 cell growth in a cell viability assay, IC50=1.47421 μM	SANGER
human K-562 cell	-	Growth inhibition assay	-	Inhibition of human K-562 cell growth in a cell viability assay, IC50=0.000162 μM	SANGER
human KGN cell	-	Growth inhibition assay	-	Inhibition of human KGN cell growth in a cell viability assay, IC50=1.0521 μM	SANGER
human KINGS-1 cell	-	Growth inhibition assay	-	Inhibition of human KINGS-1 cell growth in a cell viability assay, IC50=1.96897 μM	SANGER
human KLE cell	-	Growth inhibition assay	-	Inhibition of human KLE cell growth in a cell viability assay, IC50=1.86232 μM	SANGER
human KS-1 cell	-	Growth inhibition assay	-	Inhibition of human KS-1 cell growth in a cell viability assay, IC50=0.07758 μM	SANGER
human LAMA-84 cell	-	Growth inhibition assay	-	Inhibition of human LAMA-84 cell growth in a cell viability assay, IC50=3.78e-06 μM	SANGER
human LB1047-RCC cell	-	Growth inhibition assay	-	Inhibition of human LB1047-RCC cell growth in a cell viability assay, IC50=0.07592 μM	SANGER
human LB2518-MEL cell	-	Growth inhibition assay	-	Inhibition of human LB2518-MEL cell growth in a cell viability assay, IC50=0.04667 μM	SANGER
human LB996-RCC cell	-	Growth inhibition assay	-	Inhibition of human LB996-RCC cell growth in a cell viability assay, IC50=0.05668 μM	SANGER
human LC-2-ad cell	-	Growth inhibition assay	-	Inhibition of human LC-2-ad cell growth in a cell viability assay, IC50=0.02033 μM	SANGER
human LXF-289 cell	-	Growth inhibition assay	-	Inhibition of human LXF-289 cell growth in a cell viability assay, IC50=1.27256 μM	SANGER
human MEG-01 cell	-	Growth inhibition assay	-	Inhibition of human MEG-01 cell growth in a cell viability assay, IC50=1.63e-05 μM	SANGER
human MLMA cell	-	Growth inhibition assay	-	Inhibition of human MLMA cell growth in a cell viability assay, IC50=1.9231 μM	SANGER
human MPP-89 cell	-	Growth inhibition assay	-	Inhibition of human MPP-89 cell growth in a cell viability assay, IC50=0.08229 μM	SANGER
human NB17 cell	-	Growth inhibition assay	-	Inhibition of human NB17 cell growth in a cell viability assay, IC50=2.62875 μM	SANGER
human NB6 cell	-	Growth inhibition assay	-	Inhibition of human NB6 cell growth in a cell viability assay, IC50=1.69698 μM	SANGER
human NCI-H747 cell	-	Growth inhibition assay	-	Inhibition of human NCI-H747 cell growth in a cell viability assay, IC50=5.74159 μM	SANGER
human NCI-SNU-16 cell	-	Growth inhibition assay	-	Inhibition of human NCI-SNU-16 cell growth in a cell viability assay, IC50=0.01572 μM	SANGER
human NOS-1 cell	-	Growth inhibition assay	-	Inhibition of human NOS-1 cell growth in a cell viability assay, IC50=0.95045 μM	SANGER
human RXF393 cell	-	Growth inhibition assay	-	Inhibition of human RXF393 cell growth in a cell viability assay, IC50=0.10633 μM	SANGER
human SF126 cell	-	Growth inhibition assay	-	Inhibition of human SF126 cell growth in a cell viability assay, IC50=1.73178 μM	SANGER
human SF268 cell	-	Growth inhibition assay	-	Inhibition of human SF268 cell growth in a cell viability assay, IC50=2.48682 μM	SANGER
human SH-4 cell	-	Growth inhibition assay	-	Inhibition of human SH-4 cell growth in a cell viability assay, IC50=2.12055 μM	SANGER
human SW962 cell	-	Growth inhibition assay	-	Inhibition of human SW962 cell growth in a cell viability assay, IC50=1.33742 μM	SANGER
human TGBC24TKB cell	-	Growth inhibition assay	-	Inhibition of human TGBC24TKB cell growth in a cell viability assay, IC50=1.03831 μM	SANGER
human TK10 cell	-	Growth inhibition assay	-	Inhibition of human TK10 cell growth in a cell viability assay, IC50=1.08418 μM	SANGER
HUTU-80 cell	-	Growth inhibition assay	-	Inhibition of human HUTU-80 cell growth in a cell viability assay, IC50=0.17529 μM	SANGER
IST-MES1 cell	-	Growth inhibition assay	-	Inhibition of human IST-MES1 cell growth in a cell viability assay, IC50=0.35723 μM	SANGER
LB831-BLC cell	-	Growth inhibition assay	-	Inhibition of human LB831-BLC cell growth in a cell viability assay, IC50=0.12715 μM	SANGER
MC116 cell	-	Growth inhibition assay	-	Inhibition of human MC116 cell growth in a cell viability assay, IC50=2.85704 μM	SANGER
MFH-ino cell	-	Growth inhibition assay	-	Inhibition of human MFH-ino cell growth in a cell viability assay, IC50=0.23925 μM	SANGER
MZ1-PC cell	-	Growth inhibition assay	-	Inhibition of human MZ1-PC cell growth in a cell viability assay, IC50=0.22716 μM	SANGER
NCI-H1648 cell	-	Growth inhibition assay	-	Inhibition of human NCI-H1648 cell growth in a cell viability assay, IC50=0.51582 μM	SANGER
NTERA-S-cl-D1 cell	-	Growth inhibition assay	-	Inhibition of human NTERA-S-cl-D1 cell growth in a cell viability assay, IC50=0.28855 μM	SANGER
OS-RC-2 cell	-	Growth inhibition assay	-	Inhibition of human OS-RC-2 cell growth in a cell viability assay, IC50=0.35011 μM	SANGER
PF-382 cell	-	Growth inhibition assay	-	Inhibition of human PF-382 cell growth in a cell viability assay, IC50=0.70763 μM	SANGER
RCC10RGB cell	-	Growth inhibition assay	-	Inhibition of human RCC10RGB cell growth in a cell viability assay, IC50=0.42631 μM	SANGER
RL95-2 cell	-	Growth inhibition assay	-	Inhibition of human RL95-2 cell growth in a cell viability assay, IC50=1.32436 μM	SANGER
SNB75 cell	-	Growth inhibition assay	-	Inhibition of human SNB75 cell growth in a cell viability assay, IC50=0.35774 μM	SANGER
SW684 cell	-	Growth inhibition assay	-	Inhibition of human SW684 cell growth in a cell viability assay, IC50=0.32588 μM	SANGER
SW872 cell	-	Growth inhibition assay	-	Inhibition of human SW872 cell growth in a cell viability assay, IC50=0.86458 μM	SANGER
SW954 cell	-	Growth inhibition assay	-	Inhibition of human SW954 cell growth in a cell viability assay, IC50=0.37163 μM	SANGER
SW982 cell	-	Growth inhibition assay	-	Inhibition of human SW982 cell growth in a cell viability assay, IC50=0.85819 μM	SANGER
TE-12 cell	-	Growth inhibition assay	-	Inhibition of human TE-12 cell growth in a cell viability assay, IC50=0.88831 μM	SANGER
TE-15 cell	-	Growth inhibition assay	-	Inhibition of human TE-15 cell growth in a cell viability assay, IC50=0.24276 μM	SANGER
TE-8 cell	-	Growth inhibition assay	-	Inhibition of human TE-8 cell growth in a cell viability assay, IC50=0.23924 μM	SANGER
VA-ES-BJ cell	-	Growth inhibition assay	-	Inhibition of human VA-ES-BJ cell growth in a cell viability assay, IC50=0.4626 μM	SANGER

WH-4-023 Catalog No. CSN16229

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