CAS No.: 223499-30-7
YM-58483 Catalog No. CSN19018
Synonyms: BTP2
YM-58483 is a selective and potent blocker of store-operated Ca2+ entry (SOCE), which can regulate the activation of non-excitable cells such as lymphocytes.
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纯度 & 质量文件
批次:
靶点选择性
生物活性
- 描述
- 参考文献
- [1] Ohga K, Takezawa R, et al. Characterization of YM-58483/BTP2, a novel store-operated Ca2+ entry blocker, on T cell-mediated immune responses in vivo. Int Immunopharmacol. 2008 Dec 20;8(13-14):1787-92.
- [2] Ishikawa J, Ohga K, et al. A pyrazole derivative, YM-58483, potently inhibits store-operated sustained Ca2+ influx and IL-2 production in T lymphocytes. J Immunol. 2003 May 1;170(9):4441-9.
- [3] Yoshino T, Ishikawa J, Ohga K, Morokata T, Takezawa R, Morio H, Okada Y, Honda K, Yamada T. YM-58483, a selective CRAC channel inhibitor, prevents antigen-induced airway eosinophilia and late phase asthmatic responses via Th2 cytokine inhibition in animal models. Eur J Pharmacol. 2007 Apr 10;560(2-3):225-33
- [4] Qi Z, Wang Y, Zhou H, Liang N, Yang L, Liu L, Zhang W. The Central Analgesic Mechanism of YM-58483 in Attenuating Neuropathic Pain in Rats. Cell Mol Neurobiol. 2016 Oct;36(7):1035-43
- [5] Ohga K, Takezawa R, Arakida Y, Shimizu Y, Ishikawa J. Characterization of YM-58483/BTP2, a novel store-operated Ca2+ entry blocker, on T cell-mediated immune responses in vivo. Int Immunopharmacol. 2008 Dec 20;8(13-14):1787-92
实验方案
- 计算器
- 储存液制备
技术信息
| CAS号 | 223499-30-7 | 储存条件 |
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| 分子式 | C15H9F6N5OS | 运输 | 蓝冰 | |||||||||||
| 分子量 | 421.32 | 别名 | BTP2 | |||||||||||
| 溶解度 |
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动物实验配方 |
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