|(5S,8S,11S)-11-(2-氟乙酰)-5-异丙基-8-甲基-3,6,9-三氧代-1-苯基-2-氧杂-4,7,10-三氮杂十三烷酸甲酯|CsnPharm

CAS No.: 187389-52-2

Z-VAD(OMe)-FMK Catalog No. CSN15936

Synonyms: Z-Val-Ala-Asp(OMe)-FMK;Z-VAD-FMK;Z-Val-Ala-Asp-(OMe)-Fluoromethyl Ketone

Z-VAD(OMe)-FMK is a cell-permeable, irreversible broad-spectrum caspase inhibitor, blocks all features of apoptosis.

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靶点选择性

生物活性

实验方案

技术信息

生物活性

描述ICE (Interleukin-1βconverting enzyme)-like proteases, play a key role in the Fas-induced apoptosis in thymocytes. Z-VAD(OMe)-FMK, also called as Z-VAD-FMK, is ICE-like protease (Caspase-1, Caspase-3, Caspase-4, Caspase-5, Caspase-2, Caspase-6 and Caspase-7) inhibitor. Treatment with Z-VAD(OMe)-FMK at concentration of 10μM for 4h caused inhibition of caspase-3 cleavage at both these junctions to yield the p17 subunit in THP.1 cells exposed to an apoptotic stimulus TLCK. This cleavage could be also observed in Jurkat cells induced to undergo apoptosis by Fas antibody. These indicated that Z-VAD(OMe)-FMK could block the processing of CPP32. However, Z-VAD(OMe)-FMK did not inhibit the proteolysis of PARP, an early biochemical marker of apoptosis and also the substrate of ICE-like proteases, in cell lysates. These suggested that Z-VAD(OMe)-FMK did not inhibit CPP32 activity directly, but may block apoptosis by inhibiting the processing of CPP32^[1]. Subcutaneous administration of Z-VAD(OMe)-FMK at dose of 10mg/kg caused total lung neutrophil count increase due to inhibiting neutrophil apoptosis by Z-VAD(OMe)-FMK, as well as increase of lung cytokine response in PVM (pneumovirus pneumonia virus)-infected mice without decreasing lung caspase-3 activity directly^[2].
作用机制Z-VAD(OMe)-FMK can inhibit Fas-induced apoptosis by preventing the activation of proCPP32 (pro-Caspase-3) into its active form, rather than by blocking the proteolytic action of CPP32 (Caspase-3) directly.^[1]
细胞研究

Cell Data

Cell Lines	Concentration	Assay Type	Time	Activity Description	Data Sources
3T9 MEFs	-	Function Assay	16h	increases cytochrome c release after etoposide-treatment	22613767
3T9 MEFs	-	Function Assay	18h	upregulates initiator caspase-9 but downregulates effector caspases after etoposide treatment	22613767
4T1	2.5-10μM	Cell Viability Assay	4h	rescues the cytotoxicity of 4T1 cells induced by SPDT in a concentration dependent manner	24206161

更多
动物研究
剂量
Rat: 3 mg/kg^[3] (i.v.) Mice: 2 mg/kg - 10 mg/kg^[2] (intranasal instillation)

给药途径
i.v., intranasal instillation
参考文献

动物研究
剂量	Rat: 3 mg/kg^[3] (i.v.) Mice: 2 mg/kg - 10 mg/kg^[2] (intranasal instillation)
给药途径	i.v., intranasal instillation

[1] Slee EA, Zhu H, et al. Benzyloxycarbonyl-Val-Ala-Asp (OMe) fluoromethylketone (Z-VAD.FMK) inhibits apoptosis by blocking the processing of CPP32. Biochem J. 1996 Apr 1;315 ( Pt 1):21-4.
[2] van den Berg E, Bal SM, et al. The caspase inhibitor zVAD increases lung inflammation in pneumovirus infection in mice. Physiol Rep. 2015 Mar;3(3). pii: e12332.

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.1391 mL
- 10.6954 mL
- 21.3908 mL
- 5 mM
- 0.4278 mL
- 2.1391 mL
- 4.2782 mL
- 10 mM
- 0.2139 mL
- 1.0695 mL
- 2.1391 mL

技术信息

CAS号

187389-52-2

储存条件

粉末: Inert atmosphere,Store in freezer, under -20°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C22H30FN3O7

运输

蓝冰

分子量

467.49

别名

Z-Val-Ala-Asp(OMe)-FMK;Z-VAD-FMK;Z-Val-Ala-Asp-(OMe)-Fluoromethyl Ketone

溶解度

DMSO	500.0 mg/mL (1069.5 mM) warming
Water	insoluble

动物实验配方

IP	2% DMSO+2% Tween80+40% PEG300+water	10 mg/mL	clear
PO	0.5% CMC-Na	25 mg/mL	suspension

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Cell Lines	Concentration	Assay Type	Time	Activity Description	Data Sources

3T9 MEFs	-	Function Assay	16h	increases cytochrome c release after etoposide-treatment	22613767
3T9 MEFs	-	Function Assay	18h	upregulates initiator caspase-9 but downregulates effector caspases after etoposide treatment	22613767
4T1	2.5-10μM	Cell Viability Assay	4h	rescues the cytotoxicity of 4T1 cells induced by SPDT in a concentration dependent manner	24206161
5637	20μM	Apoptosis Assay	1h	reverses CM-induced cell death	24282433
769-P	40μM	Apoptosis Assay	48h	reduces the number of Annexin V-positive cells	25279191
A2750	20μM	Apoptosis Assay	2h	blocks caspase cleavage during helenalin treatment and reduces autophagic cell death	22784363
A375	30μM	Apoptosis Assay	2h	prevents the drug-induced PARP cleavage	25376115
A375	20μM	Apoptosis Assay	24h	reverses dicitrinone B-induced apoptosis	24699111
A431	40μM	Kinase Assay	2h	blocks fisetin-induced cleavage of caspases and PARP	23800058
A549	20 μM	Apoptosis Assay	24h	reduces cell death caused by HFCP treatment	25794149
A549	10 μM	Apoptosis Assay	24h	promotes HBC-treated A549 cell survival & attenuates the cleaved PARP expression	25683568
A549	10μM	Apoptosis Assay	24h	blocks DMAS-induced cleavage of caspase-3 and PARP and apoptotic cell death	25434989
A549	50μM	Apoptosis Assay	24h	reverses ribosome biogenesis and apoptosis caused by Chijongdan	25349781
A549	2.5-25μM	Apoptosis Assay	1h	decreases the population of apoptotic cells depend on concentrations	25342427
A549	10μM	Apoptosis Assay	3h	reduces cell apoptosis caused by PQQ	25161699
A549	50µM	Apoptosis Assay	2h	prevents the hypodiploid DNA content phase induced by cephalochromin	24588135
A549	5μM	Apoptosis Assay	24h	suppresses 6e (BK10040)-induced apoptosis	24529871
A549	100μM	Apoptosis Assay	48h	suppresses the apoptosis caused by piperine	24272201
A549	2.5μM	Apoptosis Assay	24h	decreases oridonin-induced autophagy as well and Loss of Δψm also occurred during autophagic process	24102522
A549	50μM	Apoptosis Assay	1h	blocks the BAI-induced apoptosis	22887215
A549	50μM	Apoptosis Assay	2h	partially decreases sodium selenite-induced apoptosis	22721804
A549	50μM	Apoptosis Assay	1h	prevents apoptosis induced by Baohuoside I	22687635
A549/V16	50μM	Apoptosis Assay	1h	represses TG/TM-induced apoptosis	25946033
ACH-2	0-200μM	Apoptosis Assay	2h	reduces drug-induced apoptosis and subsequent HIV-1 replication in a dose-dependent manner	25980942
ADF	40μM	Apoptosis Assay	6h	inhibits apoptosis induced by chemotherapy plus ZnCl2	24228232
AGS	10μM	Apoptosis Assay	1h	prevents curcumin-induced cleavage of caspase-3, -8, and -9 proteins	25492214
AGS	50μM	Apoptosis Assay	24h	abolishs β-lapachone-induced cell death and inhibited growth	25009698
AGS	20μM	Apoptosis Assay	12h	reduces the induction of apoptosis in response to the EtOAc fraction in a dose-dependent manner	24789703
AGS	20μM	Apoptosis Assay	12h	inhibits the activation of pro-caspase-3 in response to the EtOAc fraction	22687398
astrocytes cell	40μM	Apoptosis Assay	6h	reduces early apoptosis induced by staurosporine	23411778
BCC	50μM	Apoptosis Assay	1h	inhibits DATS-mediated growth inhibition	22519436
BEL-7402	20μM	Apoptosis Assay	1h	attenuated the apoptotic induction of III-10	26164795
Bel-7402	50μM	Caspase Activation Assay	2h	inhibits PCE-induced anoikis	23008742
Bel-7402	50μM	Apoptosis Assay	2h	inhibits PCE-induced anoikis	23008742
BGC-823	10 μM	Apoptosis Assay	24h	reduces tetrandrine-induced apoptosis	24098511
BGC-823	100μM	Apoptosis Assay	1h	partially rescues cells against damage of daidzein	22926545
BV-2	20μM	Apoptosis Assay	2h	suppresses UV-induced chromatin extrusion and dilation of the nuclear envelope	24558118
C6	50μM	Apoptosis Assay	48h	prevents the loss of cell viability caused by pregnenolone	25013479
C6	10μM	Apoptosis Assay	24h	blocks the suppressive effect of the peptide on viability	22588980
C666-1	50μM	Apoptosis Assay	24h	suppresses the cleavage of PARP and caspase-3, -7, and -9 induced by bortezomib/SAHA	23475956
Caco-2	40 μM	Apoptosis Assay	4h	prevents ST-7-induced ZO-1 changes and TER drop	24822183
Caki-1	40μM	Apoptosis Assay	48h	reduces the number of Annexin V-positive cells	25279191
Caki-1	20μM	Apoptosis Assay	1h	inhibits SCP-induced apoptosis	24504681
CAL27	10 μM	Apoptosis Assay	2h	suppresses Cur-NPs-reduced viability by up to 90%	23917396
CEF	0,33,67,100μM	Kinase Assay	15min	down-regulates PR enzyme activity to 40％ at 100μM	26102339
CL-1	20μM	Apoptosis Assay	1h	blocks OP449 induced cell death	23131782
CLL	25μM	Apoptosis Assay	1h	partially blocks MLN2238-induced cell apoptosis	24467634
CNE1	20μM	Apoptosis Assay	48h	blocks LK-A-induced apoptosis	23985029
CNE-1	20μM	Apoptosis Assay	24h	inhibits RAD001-induced cell death	23426850
CNE2	20μM	Apoptosis Assay	48h	blocks LK-A-induced apoptosis	23985029
COS7	10μM	Kinase Assay	24h	increases caspase 3/7 activities	25384025
COS7	10μM	Apoptosis Assay	48h	partially prevented FC101-induced cell death	25384025
COS-7	50µM	Function Assay	24h	affects the processing of ATN1s with polyQ tracts	23933208
Cytotoxicity Assay	20μM	Cell Viability Assay	48h	prevent MHMD-induced cell death	25392116
DLD1	20 μM	Apoptosis Assay	1h	partly reverses cell apoptosis caused by WSP1	25524246
DM6	100μM	Apoptosis Assay	72h	blocks both E2F-1 and E2Ftr-mediated cytotoxicity	22825328
DTK-SME	50μM	Apoptosis Assay	2h	partially inhibits the apoptosis induced by bupivacaine	25843897
EA.hy926	10μM	Apoptosis Assay	2h	inhibits apoptosis and facilitates autophagy in DENV2-infected EA.hy926	25138703
Ebs	10-100μM	Apoptosis Assay	24h	MMTS generation rate decreased as the concentration of z-VAD.fmk increased	25134817
EBV-transformed B cells	20μM	Apoptosis Assay	2h	blocks anti-CD80 and anti-CD86 antibody-induced apoptosis	24008628
Ec109	10μM	Apoptosis Assay	6h	blocks apoptotic combination of Tat-SmacN7 and radiation	23338568
Ec-109	10 μM	Apoptosis Assay	48h	represses PE-mediated Ec-109 cell apoptosis	23782641
Eca-109	25μM	Apoptosis Assay	30min	inhibits BJ-B11-induced cell death	23076967
EMT-6	100μM	Cytotoxicity Assay	1h	partially blocked cell death induced by siramesine	22251921
eosinophil	90μM	Apoptosis Assay	24h	inhibits apoptosis induced by Fas antibody	22079334
fetal rat lung fibroblasts	80μM	Kinase Assay	1h	inhibits Caspase-3 activity	24314135
G292	40μM	Apoptosis Assay	24h	blocks the increased cleavage of caspase-3 and PARP induced by BBMD3	24025361
GC1a	50μM	Apoptosis Assay	24h	indicates a protective effect against etoposide	26169075
H460	10μM	Apoptosis Assay	6h	blocks apoptotic combination of Tat-SmacN7 and radiation	23338568
H929	100μM	Apoptosis Assay	1h	partially blocks cell death caused by necrostatin-1	25037851
H9c2	50μM	Apoptosis Assay	1h	inhibits DOX-induced caspase 3 activation but not the loss of cells	25283819
HA	50μM	Apoptosis Assay	24h	suppresses the cleavage of PARP and caspase-3, -7, and -9 induced by bortezomib/SAHA	23475956
HaCaT	100μM	Apoptosis Assay	1h	blunts UVB-induced apoptosis in HaCaT cells	24356997
HBx	25μM	Apoptosis Assay	48h	reduced cell death induced by 3-MA	22020078
HCC	20 μM	Apoptosis Assay	2h	attenuates the DHA induced activation of PARP	22342732
HCC38	100μM	Apoptosis Assay	1h	abrogates the induction of cell death by WEE1 inhibition, TRAIL treatment, and the combination	22112940
HCEC	50μM	Function Assay	72h	restores of the normal HCEC phenotype	23742011
hCMEC/D3	25μM	Apoptosis Assay	72h	reduces LtxA induced apoptosis	23665198
HCT116	50μM	Apoptosis Assay	2h	inhibits the cell death induced by DDVP	25868818
HCT116	20μM	Apoptosis Assay	24h	abrogates of TQ-induced apoptosi	24890449
HCT116	20μM	Apoptosis Assay	24h	inhibits the cell apoptotic induced by YLT205	24713812
HCT116	100μM	Apoptosis Assay	1.5h	inhibits Os-induced cell death	23744353
HCT116	50 μM	Apoptosis Assay	2h	reverses synergistic apoptosis effects of celecoxib and NPC-16	22159752
HCT116	50 μM	Apoptosis Assay	24h	abrogates curcumin-induced cell death	22101335
HDPC	50µM	Apoptosis Assay	24h	inhibits NO-induced apoptosis	24634593
HEC-1B	20μM	Apoptosis Assay	1h	reduces TP-induced apoptosis caspase-3 and caspase-9	24213358
HeLa	10μM	Apoptosis Assay	48h	declines the rate of apoptosis dramatically	25772545
HeLa	40μM	Apoptosis Assay	24h	inhibits the increased apoptosis induced by siRNF121	24928685
HeLa	50μM	Apoptosis Assay	72h	prevents apoptosis induced by compounds 1–5	24754786
HeLa	100μM	Apoptosis Assay	24h	suppresses rate of cell death induced by overexpression of G59S or G71R p150glued	24722468
HeLa	10/20μM	Apoptosis Assay	24h	inhibits the activity of the majority of the members of the caspase-family	24137266
HeLa	20μM	Apoptosis Assay	2h	inhibits DMMP induced apoptosis	23863966
HeLa	100μM	Apoptosis Assay	2h	blocks JRS-15 Induces Apoptotic Cell Death	23344045
HeLa	50μM	Apoptosis Assay	1.5h	abrogates Chlamydia-induced apoptosis	23303804
HeLa	50 μM	Apoptosis Assay	4/8h	inhibits STS-induced late-phase apoptotic events	22460504
HeLa	50 μM	Apoptosis Assay	1h	suppresses the FRAP-induced accumulation of annexin V positive cells	22449440
HeLa	30μM	Apoptosis Assay	4h	increases the general cell viability 48 h after photodynamic treatment	22394248
HeLa	10μM	Apoptosis Assay	0.5h	inhibits apoptosis induced by the combined treatment with gomisin N and TRAIL	22179661
Hep-2	20μM	Apoptosis Assay	24h	alleviates the decrease of cell viability induced by silibinin	23580032
Hep3B	50μM	Apoptosis Assay	1h	blocks apoptosis induced by HEGCs	22923154
Hepa1-6	50μM	Apoptosis Assay	2h	inhibits curcumin and resveratrol-induced apoptosis	23446753
HepG2	20μM	Apoptosis Assay	1h	attenuated the apoptotic induction of III-10	26164795
HepG2	10μM	Apoptosis Assay	24h	reduces vimentin cleavage caused by LPS	24325816
HepG2	20μM	Apoptosis Assay	30min	inhibits the enhanced cell death by combined treatment of apigenin and TRAIL	23224239
HGL5	50μM	Apoptosis Assay	24h	indicates a protective effect against etoposide	26169075
HL60	40μM	Apoptosis Assay	40min	blocks BNDC compounds induce exposure of phosphatidylserine and DNA fragmentation	21983296
HL-60	50μM	Apoptosis Assay	48h	reduces cell death caused by SKI-II treatment	25824043
HL-60	100μM	Cytotoxicity Assay	1h	improves viability of TCNAs-treated cells	25502932
HL-60	50µM	Apoptosis Assay	1h	inhibits apoptosis induced by BA145	23948751
HL-60	100μM	Apoptosis Assay	24h	inhibits apoptosis induced by abietane diterpenes	23865778
HL-60	50µM	Apoptosis Assay	4h	blocks the cleavage of caspase-3, -9, and PARP induced by 6s	23804706
HL-60	20μM	Cytotoxicity Assay	24h	reduces the cytotoxic effect of Ery5	23494480
HL-60	100μM	Apoptosis Assay	24h	inhibits the cell apoptosis selected (+)-menthyl β-(1→6)-diglucopyranoside 5	22546669
HL-60	10-80μM	Apoptosis Assay	4h	inhibits TGHQ-induced cell apoptosis	22523229
HM7	20μM	Apoptosis Assay	1h	blocks apicularen A acetate-induced caspase-3 activation and PARP cleavage	23583412
hMSC12	100μM	Apoptosis Assay	4d	inhibits osteogenic culture-induced cell death and calcification	23657822
HONE-1	20μM	Apoptosis Assay	24h	inhibits RAD001-induced cell death	23426850
HSC-2	25/50μM	Apoptosis Assay	1h	inhibits SN-38-induced cytotoxicity	23155248
HSC-4	25/50μM	Apoptosis Assay	1h	inhibits SN-38-induced cytotoxicity	23155248
HSCs	50μM	Apoptosis Assay	24h	inhibits nilotinib-induced DNA damage indicated by PARP cleavage	23499874
HT1080	50μM	Growth Inhibition Assay	7d	inhibits the cell growth inhibition caused by combined treatment of DCA and OMP	22740984
HT-29	50μM	Apoptosis Assay	48h	blocks the apoptosis induced by kaempferol	24549175
HUVEC-2c	50μM	Apoptosis Assay	6h	decreased the ox-LDL-induced autophagy	26021729
HUVECs	10μM	Apoptosis Assay	2h	inhibits apoptosis and facilitates autophagy in DENV2-infected HUVECs	25138703
IEC-6	10μM	Apoptosis Assay	24h	prevents TcdA-induced caspase-3 cleavage and β-catenin degradation	24711571
IM-9 B	20μM	Apoptosis Assay	2h	blocks anti-CD80 and anti-CD86 antibody-induced apoptosis	24008628
IMR-32	40 μM	Apoptosis Assay	2h	decrease in apoptotic cells compared to T-2 toxin	25084755
INS-1	50μM	Apoptosis Assay	6h	decreases the proportion of early apoptotic cells	25430897
Ishikawa	25μM	Apoptosis Assay	24h	reduces cell death and apoptosis induced by Baf A1	22088918
Jurkat	20μM	Apoptosis Assay	24h	partially inhibit cell death of Jurkat cells induced by 10058-F4 combined with VPA	25120723
Jurkat	2μM	Cell Viability Assay	4h	reverses growth inhibition and β-catenin decrease by HS-ASA	23896061
Jurkat	25-100μM	Cell Viability Assay	6h	inhibits z-FA-CMK-induced cell death	23933532
Jurkat	100-200μM	Cell Viability Assay	24h	inhibits HaA4 induces apoptosis dependent of concentration	23732481
Jurkat	12.5-50μM	Apoptosis Assay	1h	dose dependently suppresses SPH-induced Par-4 cleavage, PARP cleavage, DNA fragmentation, and loss of viability	23442976
Jurkat	40μM	Apoptosis Assay	1h	abolishes FasL-induced caspase activation and cell death	22942738
Jurkat T	30μM	Apoptosis Assay	0.5h	blocks the ziram-induced apoptosis	22159898
k1735	20 μm	Apoptosis Assay	4h	inhibits Salmonella-induced apoptosis	24451116
K562	50μM	Apoptosis Assay	4h	inhibits Jac-A-induced cell apoptosis	25241619
K562	0.1-1μM	Apoptosis Assay	1h	inhibits cleavage of HSP90 in a dose-dependent manner	25119188
K562	20μM	Apoptosis Assay	48h	inhibits apoptosis induced by 4-MU	23876826
K562	100μM	Apoptosis Assay	1h	blocks Abnobaviscum F-induced apoptosis	22972372
K562	25μM	Apoptosis Assay	2h	prevents apoptosis induced by co-treatment with amurensin G and TRAIL	22483777
K562	20 μM	Apoptosis Assay	48h	blocks lapatinib-induced inhibition of viability and apoptosis induction	22216158
KB	50μM	Apoptosis Assay	24h	inhibits Lico-A-induced caspase-3 and PARP activation	24337492
KHOS	40μM	Apoptosis Assay	24h	blocks the increased cleavage of caspase-3 and PARP induced by BBMD3	24025361
KNS42	50μM	Apoptosis Assay	1h	reduces cell death and completely abolished caspase 3/7 activity in response to ABT-263/2DG/metformin combination	23691145
L02	20μM	Apoptosis Assay	1h	prevents the cell apoptosis induced by MEHP	24706461
L929	10μM	Apoptosis Assay	6h	induces necroptosis with TNF	25195660
L929	1.25–5 μM	Apoptosis Assay	24h	augments TNFα-induced necroptosis and autophagy	23941769
L929	2.5μM	Function Assay	1h	increases RIP1 expression and exacerbated TNFα-induced mitochondrial dysfunction and ROS production	23000518
L929	2.5μM	Growth Inhibition Assay	24h	inhibits the expression of p-p38 and NF-κB to augment TNFα-induced necroptosis and autophagy	22027097
L929-A	20 μM	Cytotoxicity Assay	24h	inhibits TNFα-induced cell death	25398540
L929-N	20 μM	Cytotoxicity Assay	24h	enhances death via autocrine TNFα production	25398540
LCC9	100μM	Cell Viability Assay	5d	blocks cell death induced by combination L17 and chloroquine	24785256
LLC-PK1	20μM	Apoptosis Assay	1h	prevents cisplatin-induced degradation of Atg5, beclin-1, and Atg12 proteins	22896037
LNCaP	40μM	Apoptosis Assay	2h	inhibits butein induced cell apoptosis	22114764
LNCaP	50 μM	Apoptosis Assay	24h	abrogates curcumin-induced cell death	22101335
LOVO	10 µM	Apoptosis Assay	1h	restrains cell apoptosis induced by gefitinib plus decitabine	24874286
M-14	25μM	Apoptosis Assay	0.5h	inhibits both the crude extract- and compound-induced apoptosis	21954959
macrophage	0-200μM	Cell Viability Assay	24h	induces TNF- and Rip3-dependent necroptosis in macrophage	24799565
MB231	100μM	Apoptosis Assay	1h	abrogates the induction of cell death by WEE1 inhibition, TRAIL treatment, and the combination	22112940
MB49	20μM	Apoptosis Assay	1h	reverses CM-induced cell death	24282433
MCC-2	20 μM	Apoptosis Assay	6h	blocks induced by staurosporine apoptosis cell death	24262658
MCF7	50 μM	Apoptosis Assay	1h	inhibits PA activated caspase-3, -9, and poly(ADP-ribose) polymerase	22223345
MCF-7	10μM	Apoptosis Assay	2h	inhibits the cell death induced by 3B	25722114
MCF-7	20μM	Apoptosis Assay	2h	decreases KDR-siRNA-induced apoptosis	25182240
MCF-7	20μM	Apoptosis Assay	72h	inhibits equol- and 4-OHT-mediated apoptosis	23675643
MCF-7, MDA-MB-468, Caco-2	50μM	Growth Inhibition Assay	48h	inhibits the cell growth inhibition induced by saponin	22800968
MDA-MB231	50 μM	Apoptosis Assay	24h	abrogates curcumin-induced cell death	22101335
MDA-MB-231	10μM	Cytotoxicity Assay	1h	augments cell death after CHUA treatment	25521501
MDA-MB-231	25μM	Apoptosis Assay	24h	abrogates cytotoxicity and cleavage of caspase-3 and PARP induced by Rg3	25337544
MDA-MB-231	100μM	Apoptosis Assay	1h	inhibits sensitization to TRAIL upon MTDH down-regulation	23408429
MDA-MB-231	20μM	Apoptosis Assay	4d	reduces the cell apoptosis induced by metformin treatment was significantly	22593441
MDA-MB-231	2.5-7.5μM	Apoptosis Assay	2h	inhibits the cell death of MDA-MB-231 cells induced by SDT in a concentration dependent manner	22115526
MDA-MB-468	50 μM	Apoptosis Assay	2h	blocks apoptotic DNA fragmentation induced by combination of SM-164 and radiation	21901386
MEL	20μM	Apoptosis Assay	24h	impaires P2X7-induced MEL cell apoptosis	23014887
MEL	20μM	Apoptosis Assay	1h	impaires P2X7-induced MEL cell apoptosis	23014887
mESCs	2.5μM	Apoptosis Assay	2h	inhibits the NaF-mediated caspase activation	22285274
MG-63	40μM	Apoptosis Assay	24h	blocks the increased cleavage of caspase-3 and PARP induced by BBMD3	24025361
MIA-PaCa-2	-	Apoptosis Assay	24h	blocks cleavage of caspase-3 induced by both A-443654 and paclitaxel	24510992
MKN28	10μM	Apoptosis Assay	30min	inhibits TNF-α plus CHX-induced apoptosis	25513960
MM	50μM	Apoptosis Assay	20min	partly inhibits SHK-induced cell death	25530098
MM.1S	100μM	Apoptosis Assay	1h	efficiently prevents sorafenib-induced cell death combine with necrostatin-1	25037851
Molt-3	50μM	Apoptosis Assay	2h	reduces melatonin-induced apoptosis	23725013
Molt4-hyg	10μM	Apoptosis Assay	0.5h	blocks farnesol-induced caspase-3-like activity	26275811
Nalm-6	20μM	Apoptosis Assay	4h	inhibits caspase-8 and caspase-3 activation and PARP-1 cleavage	24039967
NB2a/d1	100μM	Apoptosis Assay	72h	attenuates staurosporine-induced caspase activity, PARP, and tau cleavage	22988541
NBL-W-S	50μM	Apoptosis Assay	1h	fully rescues cell viability after GANT-61 treatment	25323222
Neocortical Neuron	100μM	Neurotoxicity Assay	1h	antagonizes Hoiamide A-Induced Neurotoxicity	25675001
Neutrophil	20μM	Apoptosis Assay	0.5h	attenuates the pro-apoptotic effect of MaR1	26196844
NLRP3-Tet-on-MC/9	10-40μM	Apoptosis Assay	12h	attenuates the cell death caused by CAPS-associated NLRP3 mutants in the Tet-on system	23703389
OS	20/40μM	Apoptosis Assay	72h	inhibits OS cell viability reduction by C6 ceramide	25152399
OS	20μM	Apoptosis Assay	4h	inhibits the cell death caused by PDT	24204937
P815	100 µM	Apoptosis Assay	12h	inhibits virus-induced apoptosis	24923273
PC3	10μM	Apoptosis Assay	4h	counters flavocoxid-induced caspase-related apoptosis	22471974
PDL fibroblasts	80μM	Kinase Assay	1h	inhibits Caspase-3 activity	24314135
PLC/PRF/5c	50μM	Apoptosis Assay	1h	prevents apoptosis triggered by CIN	23438824
PMNs	40μM	Apoptosis Assay	6h	reversed the amount of cleaved caspase-3 to near vehicle levels	22692577
podocytes	200μM	Apoptosis Assay	6h	inhibits apoptosis induced by 3,4-DGE	24337777
Primary hepatocytes	50μM	Apoptosis Assay	18h	inhibits apoptosis of hepatocytes induced by Act D and TNF-α	25407538
Primary human placental cytotrophoblasts	30μM	Apoptosis Assay	24h	reverses the inhibition of 11β-HSD2 by triclosan	25642592
primary MEFs	-	Function Assay	12h	increases etoposide-induced mitochondrial membrane depolarization	22613767
Primary OPC	1μM	Apoptosis Assay	6h/24h	reduces the percentage of cells in early- and late-apoptosis/necrosis	22707385
Primary rat cerebral cortical neurons	100μM	Apoptosis Assay	1h	prevents Cd-induced apoptosis and cell death	23741317
QGY7701	25μM	Apoptosis Assay	1.5h	inhibits accumulation of sub-G1 phase induced by DOX + quercetin	23240061
RAW 264.7	20μM	Apoptosis Assay	18h	increases LC3-II/β-actin ratio compared to ECTV-MOS treatment only	24116707
RAW 264.7	50/100μM	Apoptosis Assay	1h	concentration-dependent inhibits DON-induced rRNA cleavage	22491426
RAW264.7	10 μM	Apoptosis Assay	24h	decreases the apoptosis induced by GA	23820203
RCC	100μM	Cell Viability Assay	24h	recoveres the viability of cells exposed to 15d-PGJ2	22991494
RKO	10 μM	Cell Viability Assay	24h	inhibits the decrease of cell viability caused by DAB	23758064
RKO-HIPK2i	40μM	Apoptosis Assay	6h	inhibits apoptosis induced by chemotherapy plus ZnCl2	24228232
RPE	100μM	Apoptosis Assay	48h	partially inhibits the calpain-1 and -2 activation as well as the caspase activation	24202052
RPMI 8226	100μM	Apoptosis Assay	1h	almost completely blocks cell death caused by necrostatin-1	25037851
SCCVII	25μM	Apoptosis Assay	1h	inhibits the cell killing after dasatinib	24126464
SGC-7901	20 μM	Apoptosis Assay	1h	inhibits the cell death induced by oxaliplatin	25767076
SGC-7901	10μM	Apoptosis Assay	24h	promotes the CGII-inhibited cell growth in SGC-7901 cells	24454488
SGC-7901	10μM	Apoptosis Assay	24h	inhibits β,β-dimethylacrylshikonin-induced apoptosis	22848597
SGC-7901	20 μM	Apoptosis Assay	2h	attenuates H2O2 or TNF α-induced cell apoptosis as well as caspase-3 activity	22471589
SGN	20mM	Apoptosis Assay	48h	has no influence on AIF, calpain expression or cell apoptosis	25874633
shC9	10μM	Apoptosis Assay	16h	blunts SHH expression in shC9 cells exposed to either PA or LPC	22641094
SH-SY5Y	10μM	Apoptosis Assay	24h	attenuates caspase activation and cell death induced by HNE-2DG	24145463
SK-BR-3	50 μM	Apoptosis Assay	2h	blocks apoptotic DNA fragmentation induced by combination of SM-164 and radiation	21901386
SK-HEP1	100μM	Apoptosis Assay	1h	inhibits CrT1 activated caspase-3, -7, -8, -9, and poly(ADP-ribose) polymerase	23302650
SMMC-7721	50μM	Apoptosis Assay	48h	attenuates oTR-induced apoptosis	22465833
SNU449	20μM	Apoptosis Assay	48h	decreases miR-451-induced apoptotic	24841638
SP2/0	100μM	Apoptosis Assay	1h	blocks the apoptosis of SP2/0 cells	26074732
SW1116	10 µM	Apoptosis Assay	1h	restrains cell apoptosis induced by gefitinib plus decitabine	24874286
T cell	0-100μM	Cell proliferation assay	72h	IC50=70 μM, inhibits anti-CD3-induced T cell proliferation in PBMCs	24768707
T cell	25-100μM	Growth Inhibition Assay	24h	dose-dependently inhibited T cell proliferation mediated through the co-stimulation with anti-CD3 and anti-CD28	22982538
T47D	100μM	Apoptosis Assay	1h	blocks the generation of E-cad/CTF2 by STS	22401168
T98G	1-100μM	Cell Viability Assay	24h	improves cell viability cotreatment with TS	23769275
THP-1	10μM	Apoptosis Assay	1h	reduces apoptosis induced by ALA-SDT	24923653
THP-1	10-50μM	Apoptosis Assay	2h	inhibits apoptosis induced by triptolide	23900299
U1	0-100μM	Apoptosis Assay	2h	reduces drug-induced apoptosis and subsequent HIV-1 replication in a dose-dependent manner	25980942
U1	100μM	Kinase Assay	2h	inhibits caspase-3	25980942
U251	20μM	Apoptosis Assay	24h	inhibits casticin induced G2/M phase arrest and apoptosis	23816816
U266	100μM	Apoptosis Assay	1h	partially blocks cell death caused by necrostatin-1	25037851
U373	40μM	Apoptosis Assay	6h	inhibits apoptosis induced by chemotherapy plus ZnCl2	24228232
U87	50μM	Growth Inhibition Assay	1h	recovers cell growth from TMZ treatment	25681668
U87	25μM	Apoptosis Assay	2h	decreases isoliquiritigenin (ISL)-induced apoptotic cell death, but not necrotic cell death	23229626
U87	20μM	Apoptosis Assay	24h	reduces the apoptosis rate induced by PLAB	22778780
U937	50μM	Apoptosis Assay	48h	reduces cell death caused by SKI-II treatment	25824043
U937	10 μM	necroptosis Assay	30 min	induces necroptosis combine with TNF	24773756
U937	50 μM	Apoptosis Assay	1h	inhibits HF-induced apoptosis	21998731
U-937	10μM	Apoptosis Assay	30min	prevents TNF-induced necroptosis	23410748
UD29a	50μM	Apoptosis Assay	24h	inhibits the cell death caused by NUT3	24190574
UM-SCC-10A	50µM	Apoptosis Assay	2h	reduces apoptosis induced by high-dose isoalantolactone	24098753
YD-8	100μM	Apoptosis Assay	1h	inhibits PLEO-induced apoptosis	22086183
YD-8	100μM	Apoptosis Assay	1h	blocks the GS-HCl-induced apoptosis	22020078

Z-VAD(OMe)-FMK Catalog No. CSN15936

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