|N-[4-[[6-甲氧基-7-[3-(4-吗啉基)丙氧基]-4-喹唑啉基]氨基]苯基]苯甲酰胺|CsnPharm

CAS No.: 331771-20-1

ZM-447439 Catalog No. CSN12727

Synonyms: ZM447439

ZM 447439 is a selective and ATP-competitive inhibitor for Aurora A and Aurora B with IC50 of 110 nM, 130 nM respectively, > 8 fold selectivity than Aurora C, MEK1, Src.

规格	价格	促销价格	库存	数量

400-920-2911

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tech@csnpharm.cn

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纯度 & 质量文件批次:

靶点选择性

生物活性

实验方案

技术信息

生物活性

靶点 Aurora Kinase A

IC50:110nM Aurora Kinase B

IC50:130nM
描述ZM 447439 is a selective and ATP-competitive inhibitor for Aurora A and Aurora B with IC50 of 110 nM, 130 nM respectively, > 8 fold selectivity than Aurora C, MEK1, Src.
细胞研究

Cell Data

Cell Lines	Concentration	Assay Type	Time	Activity Description	Data Sources
human A172 cell	-	Growth inhibition assay	-	Inhibition of human A172 cell growth in a cell viability assay, IC50=0.98411 μM	SANGER
human A498 cell	-	Growth inhibition assay	-	Inhibition of human A498 cell growth in a cell viability assay, IC50=2.3669 μM	SANGER
human ABC-1 cell	-	Growth inhibition assay	-	Inhibition of human ABC-1 cell growth in a cell viability assay, IC50=1.40352 μM	SANGER

更多
动物研究
剂量
Mice: 80 mg/kg^[3] (i.p.)

给药途径
i.p.
参考文献

动物研究
剂量	Mice: 80 mg/kg^[3] (i.p.)
给药途径	i.p.

[1] Georgieva I, Koychev D, et al. ZM447439, a novel promising aurora kinase inhibitor, provokes antiproliferative and proapoptotic effects alone and in combination with bio- and chemotherapeutic agents in gastroenteropancreatic neuroendocrine tumor cell lines. Neuroendocrinology. 2010;91(2):121-30.
[2] Ditchfield C, Johnson VL, et al. Aurora B couples chromosome alignment with anaphase by targeting BubR1, Mad2, and Cenp-E to kinetochores. J Cell Biol. 2003 Apr 28;161(2):267-80.

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 1.9471 mL
- 9.7354 mL
- 19.4709 mL
- 5 mM
- 0.3894 mL
- 1.9471 mL
- 3.8942 mL
- 10 mM
- 0.1947 mL
- 0.9735 mL
- 1.9471 mL

技术信息

CAS号

331771-20-1

储存条件

粉末: Sealed in dry,Store in freezer, under -20°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C29H31N5O4

运输

蓝冰

分子量

513.59

别名

ZM447439

溶解度

DMSO	103.0 mg/mL (200.6 mM)
Water	Insoluble
Ethanol	Insoluble

动物实验配方

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Cell Lines	Concentration	Assay Type	Time	Activity Description	Data Sources

human A172 cell	-	Growth inhibition assay	-	Inhibition of human A172 cell growth in a cell viability assay, IC50=0.98411 μM	SANGER
human A498 cell	-	Growth inhibition assay	-	Inhibition of human A498 cell growth in a cell viability assay, IC50=2.3669 μM	SANGER
human ABC-1 cell	-	Growth inhibition assay	-	Inhibition of human ABC-1 cell growth in a cell viability assay, IC50=1.40352 μM	SANGER
human BE-13 cell	-	Growth inhibition assay	-	Inhibition of human BE-13 cell growth in a cell viability assay, IC50=0.84418 μM	SANGER
human CAL-51 cell	-	Growth inhibition assay	-	Inhibition of human CAL-51 cell growth in a cell viability assay, IC50=1.83845 μM	SANGER
human COLO-800 cell	-	Growth inhibition assay	-	Inhibition of human COLO-800 cell growth in a cell viability assay, IC50=1.70382 μM	SANGER
human CTB-1 cell	-	Growth inhibition assay	-	Inhibition of human CTB-1 cell growth in a cell viability assay, IC50=1.67082 μM	SANGER
human DOHH-2 cell	-	Growth inhibition assay	-	Inhibition of human DOHH-2 cell growth in a cell viability assay, IC50=1.40276 μM	SANGER
human ECC10 cell	-	Growth inhibition assay	-	Inhibition of human ECC10 cell growth in a cell viability assay, IC50=1.63353 μM	SANGER
human EM-2 cell	-	Growth inhibition assay	-	Inhibition of human EM-2 cell growth in a cell viability assay, IC50=1.41721 μM	SANGER
human EoL-1-cell	-	Growth inhibition assay	-	Inhibition of human EoL-1-cell cell growth in a cell viability assay, IC50=0.18678 μM	SANGER
human ES3 cell	-	Growth inhibition assay	-	Inhibition of human ES3 cell growth in a cell viability assay, IC50=0.4732 μM	SANGER
human ES5 cell	-	Growth inhibition assay	-	Inhibition of human ES5 cell growth in a cell viability assay, IC50=1.00248 μM	SANGER
human ES8 cell	-	Growth inhibition assay	-	Inhibition of human ES8 cell growth in a cell viability assay, IC50=0.49806 μM	SANGER
human H4 cell	-	Growth inhibition assay	-	Inhibition of human H4 cell growth in a cell viability assay, IC50=1.81578 μM	SANGER
human H9 cell	-	Growth inhibition assay	-	Inhibition of human H9 cell growth in a cell viability assay, IC50=0.92979 μM	SANGER
human HCT-116 cells	-	Growth inhibition assay	-	Inhibition of human HCT-116 cell growth in a cell viability assay, IC50=1.80908 μM	SANGER
human HN cell	-	Growth inhibition assay	-	Inhibition of human HN cell growth in a cell viability assay, IC50=1.9251 μM	SANGER
human IST-SL1 cell	-	Growth inhibition assay	-	Inhibition of human IST-SL1 cell growth in a cell viability assay, IC50=1.31727 μM	SANGER
human KARPAS-45 cell	-	Growth inhibition assay	-	Inhibition of human KARPAS-45 cell growth in a cell viability assay, IC50=0.38128 μM	SANGER
human KE-37 cell	-	Growth inhibition assay	-	Inhibition of human KE-37 cell growth in a cell viability assay, IC50=1.21388 μM	SANGER
human L-363 cell	-	Growth inhibition assay	-	Inhibition of human L-363 cell growth in a cell viability assay, IC50=1.9512 μM	SANGER
human LAMA-84 cell	-	Growth inhibition assay	-	Inhibition of human LAMA-84 cell growth in a cell viability assay, IC50=1.7552 μM	SANGER
human LK-2 cell	-	Growth inhibition assay	-	Inhibition of human LK-2 cell growth in a cell viability assay, IC50=1.64594 μM	SANGER
human LoVo cells	-	Proliferation assay	72 h	Antiproliferative activity against human LoVo cells after 72 hrs by MTT-based WST8 reagent assay, IC50=1.9 μM	25270403
human MOLT-13 cell	-	Growth inhibition assay	-	Inhibition of human MOLT-13 cell growth in a cell viability assay, IC50=1.56706 μM	SANGER
human MOLT-16 cell	-	Growth inhibition assay	-	Inhibition of human MOLT-16 cell growth in a cell viability assay, IC50=0.60961 μM	SANGER
human MOLT-4 cell	-	Growth inhibition assay	-	Inhibition of human MOLT-4 cell growth in a cell viability assay, IC50=0.89978 μM	SANGER
human MV-4-11 cell	-	Growth inhibition assay	-	Inhibition of human MV-4-11 cell growth in a cell viability assay, IC50=0.7963 μM	SANGER
human NB14 cell	-	Growth inhibition assay	-	Inhibition of human NB14 cell growth in a cell viability assay, IC50=1.55621 μM	SANGER
human NB7 cell	-	Growth inhibition assay	-	Inhibition of human NB7 cell growth in a cell viability assay, IC50=1.75297 μM	SANGER
human NBsusSR cell	-	Growth inhibition assay	-	Inhibition of human NBsusSR cell growth in a cell viability assay, IC50=0.91387 μM	SANGER
human NCI-H1581 cell	-	Growth inhibition assay	-	Inhibition of human NCI-H1581 cell growth in a cell viability assay, IC50=1.6755 μM	SANGER
human NCI-H209 cell	-	Growth inhibition assay	-	Inhibition of human NCI-H209 cell growth in a cell viability assay, IC50=1.16602 μM	SANGER
human NCI-H720 cell	-	Growth inhibition assay	-	Inhibition of human NCI-H720 cell growth in a cell viability assay, IC50=1.20627 μM	SANGER
human NCI-H747 cell	-	Growth inhibition assay	-	Inhibition of human NCI-H747 cell growth in a cell viability assay, IC50=2.03353 μM	SANGER
human NKM-1 cell	-	Growth inhibition assay	-	Inhibition of human NKM-1 cell growth in a cell viability assay, IC50=1.16798 μM	SANGER
human NOMO-1 cell	-	Growth inhibition assay	-	Inhibition of human NOMO-1 cell growth in a cell viability assay, IC50=1.36725 μM	SANGER
human P12-ICHIKAWA cell	-	Growth inhibition assay	-	Inhibition of human P12-ICHIKAWA cell growth in a cell viability assay, IC50=0.22441 μM	SANGER
human Ramos-2G6-4C10 cell	-	Growth inhibition assay	-	Inhibition of human Ramos-2G6-4C10 cell growth in a cell viability assay, IC50=1.40605 μM	SANGER
human RKO cell	-	Growth inhibition assay	-	Inhibition of human RKO cell growth in a cell viability assay, IC50=0.70656 μM	SANGER
human RS4-11 cell	-	Growth inhibition assay	-	Inhibition of human RS4-11 cell growth in a cell viability assay, IC50=0.5544 μM	SANGER
human SBC-1 cell	-	Growth inhibition assay	-	Inhibition of human SBC-1 cell growth in a cell viability assay, IC50=1.03928 μM	SANGER
human SK-NEP-1 cell	-	Growth inhibition assay	-	Inhibition of human SK-NEP-1 cell growth in a cell viability assay, IC50=1.36498 μM	SANGER
human SW48 cell	-	Growth inhibition assay	-	Inhibition of human SW48 cell growth in a cell viability assay, IC50=1.23155 μM	SANGER
human SW954 cell	-	Growth inhibition assay	-	Inhibition of human SW954 cell growth in a cell viability assay, IC50=0.83635 μM	SANGER
human TE-11 cell	-	Growth inhibition assay	-	Inhibition of human TE-11 cell growth in a cell viability assay, IC50=0.53703 μM	SANGER
MCF7 cell	-	Proliferation assay	-	Antiproliferative activity against MCF7 cell line, IC50=0.198 μM	16337122
SK-UT-1 cell	-	Growth inhibition assay	-	Inhibition of human SK-UT-1 cell growth in a cell viability assay, IC50=1.8153 μM	SANGER

靶点	Description	IC50
Aurora Kinase A		IC50:110nM
Aurora Kinase B		IC50:130nM

ZM-447439 Catalog No. CSN12727

靶点选择性

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