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RAR/RXR
| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| CSN15864 | Vitamin A | 68-26-8 | Vitamin A is an effective antioxidant that displays lipoperoxy radical scavenging activity and fluorescent properties. It's a ligand for both the retinoic acid receptor (RAR) and the retinoid X receptor (RXR). |
| CSN23178 | UVI 3003 | 847239-17-2 | UVI 3003 is a potent and selective RXR antagonist, used as a tool to test the contribution of RXR to transactivation by a given RXR heterodimer. |
| CSN16014 | TTNPB | 71441-28-6 | TTNPB is an agonist of RAR and can inhibit binding of [3H]tRA with RARα (IC50 = 5.1 nM), RARβ (IC50 = 4.5 nM), and RARγ (IC50 = 9.3 nM). |
| CSN21330 | Trifarotene | 895542-09-3 | Trifarotene is a retinoic acid receptor (RAR) agonist with Kdapp of 2, 15 and 500 nM for RARγ, RARβ and RARα, respectively. |
| CSN21850 | Temarotene | 75078-91-0 | Temarotene is a synthetic bioactive retinoid with differentiation inducing and potential antineoplastic activitiesa and activates retinoic acid receptors (RARs). |
| CSN26162 | Tazarotenic acid | 118292-41-4 | Tazarotenic Acid is the principle active metabolite of Tazarotene. It is a potent and selective agonist of RAR. |
| CSN16696 | Tazarotene | 118292-40-3 | Tazarotene selectively binds to retinoic acid receptors RAR-β and RAR-γ, it is the first receptor-selective aromatic retinoid that has effective treatment for psoriasis, hemorrhoids. |
| CSN19418 | Retinoic acid | 302-79-4 | Retinoic acid is a ligand for retinoic acid receptor (RAR) and retinoid X receptor (RXR) that can prime embryonic stem cells to become neurons and induce granulocytic differentiation. |
| CSN28465 | PROTAC RAR Degrader-1 | 1351169-27-1 | PROTAC RAR Degrader-1 comprises a cIAP1 ligand binding group, a linker and a RAR ligand binding group. PROTAC RAR Degrader-1 is an RAR degrader. Maximal RAR degradation at 30 μM concentration in HT1080 cells. Degradation inducers based on cIAP1 are called specific and non-genetic IAP-dependent protein erasers (SNIPERs). |
| CSN18263 | Palovarotene | 410528-02-8 | Palovarotene is a selective retinoic acid receptor gamma (RAR-γ) agonist for the treatment of emphysema. |
| CSN23021 | PA452 | 457657-34-0 | PA 452 is a RXR antagonist with pA2 of 7.11. |
| CSN20408 | LY2955303 | 1433497-19-8 | LY2955303 is a selective antagonist of RAR-gamma with Ki of 1.09 nM that used to treatm osteoarthritis pain. |
| CSN26241 | LG100754 | 180713-37-5 | LG100754 is a RXR dimers modulater. LG100754 acts as a RXR:RXR homodimer antagonist, but functions as a agonist towards RXR:PPARα and RXR:PPARγ heterodimers. |
| CSN22120 | LG-100064 | 153559-46-7 | LG-100064 is an agonist of RXRα, RXRβ and RXRγ with EC50s of 330 nM, 200 nM, and 260 nM, respectively. |
| CSN22885 | Lg 101506 | 331248-11-4 | LG 101506 is a selective RXR modulator with Kis of 3, 9 and 11 nM for RXRα, RXRβ and RXRγ respectively. |
| CSN22884 | LG100268 | 153559-76-3 | LG 100268 is a potent and selective retinoid X receptor (RXR) agonist with EC50 of 4 nM. |
| CSN22883 | LE135 | 155877-83-1 | LE 135 is a selective RARβ antagonist with Ki of 0.22 μM. |
| CSN16741 | Isotretinoin | 4759-48-2 | Isotretinoin, an analogue of retinoic acid, is an agonist of retinoic acid receptors that is used for the treatment of severe acne. |
| CSN22852 | Hx 630 | 188844-52-2 | HX 630 is a RXR agonist. |
| CSN22851 | HX531 | 188844-34-0 | HX 531 is a potent RXR antagonist with IC50 of 18 nM. |
| CSN22819 | Fluorobexarotene | 1190848-23-7 | Fluorobexarotene is a RXR agonist with Ki of 12 nM and EC50 of 43 nM at RXRα receptors. |
| CSN19519 | Fenretinide | 65646-68-6 | Fenretinide, the deriverative of retinoid, can bind to retinoic acid receptors (RAR) and induce cell death. |
| CSN16756 | Etretinate | 54350-48-0 | Etretinate is a second-generation retinoid and an agonist for retinoic acid receptors to treat severe psoriasis. |
| CSN22811 | ER 50891 | 187400-85-7 | ER 50891 is an antagonist of RARα receptors with IC50 of 31.2 nM. |
| CSN20371 | Docosahexaenoic acid | 6217-54-5 | Docosahexaenoic acid, an endogenous omega-3 fatty acid, acts as a selective retinoid X receptor (RXR) agonist that displays no activity at RAR, thyroid hormone receptor or the vitamin D receptor (VDR). |
| CSN22751 | Ch55 | 110368-33-7 | CH-55 is a potent agonist for RAR-α and RAR-β receptors. |
| CSN22142 | CD437 | 125316-60-1 | CD437 is a selective Retinoic Acid Receptor γ (RARγ) agonist. |
| CSN22746 | CD3254 | 196961-43-0 | CD 3254 is a selective RXRα agonist. |
| CSN22745 | CD2314 | 170355-37-0 | CD 2314 is a potent and selective RARβ receptor agonist with Kd of 145 nM. |
| CSN22744 | CD1530 | 107430-66-0 | CD 1530 is a potent and selective RARγ receptor agonist with Ki of 150 nM. |
| CSN26248 | BMS493 | 215030-90-3 | BMS493 is an inverse agonist of pan-retinoic acid receptors (pan-RARs). BMS493 has been shown to increase nuclear corepressor (NCoR) interaction with RARs. BMS493 completely inhibited atRA-induced Sub-G1 fraction, DNA fragmentation, and caspase-3 activation. |
| CSN22719 | BMS961 | 185629-22-5 | BMS 961 is a selective RARγ agonist with EC50 of 30 nM. |
| CSN22717 | BMS-195614 | 182135-66-6 | BMS 195614 is a neutral retinoic acid receptor (RAR) α-selective antagonist with Ki of 2.5 nM. |
| CSN19473 | Bexarotene | 153559-49-0 | Bexarotene is a selective agonist of RXRβ (IC50 = 24 nM), RXRγ (IC50 = 25 nM) and RXRα (IC50 = 33 nM) with antineoplastic activity. |
| CSN22084 | AR7 | 80306-38-3 | AR7 is a retinoic acid receptor α (RARα) antagonist. |
| CSN12870 | AM580 | 102121-60-8 | AM580 is the stable retinobenzoic derivative that acts as an agonist of RARα. |
| CSN24873 | All-trans-retinal | 116-31-4 | All trans-Retinal, a component of the retinoid cycle, is converted to retinoic acid in vivo by the action of retinal dehydrogenase. Retinoic acid is a ligand for both RAR and RXR. All trans-retinal ias a potent photosensitizer. |
| CSN18484 | AGN 205728 | 859498-05-8 | AGN 205728 is a potent and selective RARγ antagonist with Ki/IC95 values of 3 nM/ 0.6 nM showing no inhibiton on RARα and RARβ. |
| CSN17042 | AGN 196996 | 958295-17-5 | AGN 196996 is a potent and selective RARα antagonist with Ki value of 2 nM showing little binding affinity for RARβ (Ki=1087 nM) and RARγ (Ki=8523 nM). |
| CSN13752 | AGN-195183 | 367273-07-2 | AGN 195183 is a potent and selective agonist of RARα (Kd=3 nM) with improved binding selectivity relative to AGN 193836, displaying no activity on RARβ/γ. |
| CSN18141 | AGN 194310 | 229961-45-9 | AGN 194310 is a potent and selective pan-RARs agonist with Kd values of 3/2/5 nM for RARα/β/γ respectively. |
| CSN21338 | AGN 194078 | 321995-62-4 | AGN 194078 is a selective RARα agonist with a Kd and EC50 of 3 and 112 nM, respectively. |
| CSN22670 | AGN 193109 | 171746-21-7 | AGN 193109 is a high affinity pan-retinoic acid receptor (RAR) antagonist with Kds of 2, 2 and 3 nM at RARα, RARβ and RARγ, respectively. |
| CSN18560 | Adapalene sodium salt | 911110-93-5 | Adapalene sodium is a synthetic retinoid which is a Retinoic acid receptor agonist (RAR). |
| CSN18590 | Acitretin sodium | 925701-88-8 | Acitretin sodium is a second-generation, systemic retinoid and an agonist for retinoic acid receptors that has been used in the treatment of psoriasis. |
| CSN12772 | Acitretin | 55079-83-9 | Acitretin is an analog of retinoid that can activate α-secretase ADAM10 gene expression. It has been used in the treatment of severe psoriasis. |
| CSN19699 | AC-55649 | 59662-49-6 | AC55649 is an agonist of the retinoic acid receptor β (RAR-β). |
| CSN12719 | Tarenflurbil | 51543-40-9 | (R)-Flurbiprofen is the R-enantiomer of the racemate NSAID flurbiprofen, inhibiting the binding of [3H]9-cis-RA to RXRαLBD with IC50 of 75 μM. |
| CSN93618 | 9-cis-Retinoic acid | 5300-03-8 |
