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RAR/RXR

RAR/RXR

货号 产品名 CAS号 信息
CSN15864 (2E,4E,6E,8E)-3,7-Dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)nona-2,4,6,8-tetraen-1-ol 68-26-8 Vitamin A is an effective antioxidant that displays lipoperoxy radical scavenging activity and fluorescent properties. It's a ligand for both the retinoic acid receptor (RAR) and the retinoid X receptor (RXR).
CSN23178 UVI 3003 847239-17-2 UVI 3003 is a potent and selective RXR antagonist, used as a tool to test the contribution of RXR to transactivation by a given RXR heterodimer.
CSN16014 TTNPB (Arotinoid Acid) 71441-28-6 TTNPB is an agonist of RAR and can inhibit binding of [3H]tRA with RARα (IC50 = 5.1 nM), RARβ (IC50 = 4.5 nM), and RARγ (IC50 = 9.3 nM).
CSN21330 Trifarotene 895542-09-3 Trifarotene is a retinoic acid receptor (RAR) agonist with Kdapp of 2, 15 and 500 nM for RARγ, RARβ and RARα, respectively.
CSN21850 Temarotene 75078-91-0 Temarotene is a synthetic bioactive retinoid with differentiation inducing and potential antineoplastic activitiesa and activates retinoic acid receptors (RARs).
CSN26162 Tazarotenic acid 118292-41-4 Tazarotenic Acid is the principle active metabolite of Tazarotene. It is a potent and selective agonist of RAR.
CSN16696 Ethyl 6-((4,4-dimethylthiochroman-6-yl)ethynyl)nicotinate 118292-40-3 Tazarotene selectively binds to retinoic acid receptors RAR-β and RAR-γ, it is the first receptor-selective aromatic retinoid that has effective treatment for psoriasis, hemorrhoids.
CSN19418 (2E,4E,6E,8E)-3,7-Dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)nona-2,4,6,8-tetraenoic acid 302-79-4 Retinoic acid is a ligand for retinoic acid receptor (RAR) and retinoid X receptor (RXR) that can prime embryonic stem cells to become neurons and induce granulocytic differentiation.
CSN28465 PROTAC RAR Degrader-1 1351169-27-1 PROTAC RAR Degrader-1 comprises a cIAP1 ligand binding group, a linker and a RAR ligand binding group. PROTAC RAR Degrader-1 is an RAR degrader. Maximal RAR degradation at 30 μM concentration in HT1080 cells. Degradation inducers based on cIAP1 are called specific and non-genetic IAP-dependent protein erasers (SNIPERs).
CSN18263 Palovarotene 410528-02-8 Palovarotene is a selective retinoic acid receptor gamma (RAR-γ) agonist for the treatment of emphysema.
CSN23021 PA452 457657-34-0 PA 452 is a RXR antagonist with pA2 of 7.11.
CSN20408 LY2955303 1433497-19-8 LY2955303 is a selective antagonist of RAR-gamma with Ki of 1.09 nM that used to treatm osteoarthritis pain.
CSN26241 LG100754 180713-37-5 LG100754 is a RXR dimers modulater. LG100754 acts as a RXR:RXR homodimer antagonist, but functions as a agonist towards RXR:PPARα and RXR:PPARγ heterodimers.
CSN22120 LG-100064 153559-46-7 LG-100064 is an agonist of RXRα, RXRβ and RXRγ with EC50s of 330 nM, 200 nM, and 260 nM, respectively.
CSN22885 LG101506 331248-11-4 LG 101506 is a selective RXR modulator with Kis of 3, 9 and 11 nM for RXRα, RXRβ and RXRγ respectively.
CSN22884 LG100268 153559-76-3 LG 100268 is a potent and selective retinoid X receptor (RXR) agonist with EC50 of 4 nM.
CSN22883 LE135 155877-83-1 LE 135 is a selective RARβ antagonist with Ki of 0.22 μM.
CSN16741 Isotretinoin 4759-48-2 Isotretinoin, an analogue of retinoic acid, is an agonist of retinoic acid receptors that is used for the treatment of severe acne.
CSN22852 HX630 188844-52-2 HX 630 is a RXR agonist.
CSN22851 HX531 188844-34-0 HX 531 is a potent RXR antagonist with IC50 of 18 nM.
CSN22819 Fluorobexarotene 1190848-23-7 Fluorobexarotene is a RXR agonist with Ki of 12 nM and EC50 of 43 nM at RXRα receptors.
CSN19519 all-trans-N-(4-Hydroxyphenyl)retinamide 65646-68-6 Fenretinide, the deriverative of retinoid, can bind to retinoic acid receptors (RAR) and induce cell death.
CSN16756 Etretinate 54350-48-0 Etretinate is a second-generation retinoid and an agonist for retinoic acid receptors to treat severe psoriasis.
CSN22811 ER 50891 187400-85-7 ER 50891 is an antagonist of RARα receptors with IC50 of 31.2 nM.
CSN20371 Docosahexaenoic Acid 6217-54-5 Docosahexaenoic acid, an endogenous omega-3 fatty acid, acts as a selective retinoid X receptor (RXR) agonist that displays no activity at RAR, thyroid hormone receptor or the vitamin D receptor (VDR).
CSN22751 Ch55 110368-33-7 CH-55 is a potent agonist for RAR-α and RAR-β receptors.
CSN22142 CD 437 125316-60-1 CD437 is a selective Retinoic Acid Receptor γ (RARγ) agonist.
CSN22746 CD3254 196961-43-0 CD 3254 is a selective RXRα agonist.
CSN22745 CD2314 170355-37-0 CD 2314 is a potent and selective RARβ receptor agonist with Kd of 145 nM.
CSN22744 CD1530 107430-66-0 CD 1530 is a potent and selective RARγ receptor agonist with Ki of 150 nM.
CSN26248 BMS493 215030-90-3 BMS493 is an inverse agonist of pan-retinoic acid receptors (pan-RARs). BMS493 has been shown to increase nuclear corepressor (NCoR) interaction with RARs. BMS493 completely inhibited atRA-induced Sub-G1 fraction, DNA fragmentation, and caspase-3 activation.
CSN22719 BMS961 185629-22-5 BMS 961 is a selective RARγ agonist with EC50 of 30 nM.
CSN22717 BMS-195614 182135-66-6 BMS 195614 is a neutral retinoic acid receptor (RAR) α-selective antagonist with Ki of 2.5 nM.
CSN19473 4-(1-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)vinyl)benzoic acid   153559-49-0 Bexarotene is a selective agonist of RXRβ (IC50 = 24 nM), RXRγ (IC50 = 25 nM) and RXRα (IC50 = 33 nM) with antineoplastic activity.
CSN22084 AR7 80306-38-3 AR7 is a retinoic acid receptor α (RARα) antagonist.
CSN12870 4-(5,5,8,8-Tetramethyl-5,6,7,8-tetrahydronaphthalene-2-carboxamido)benzoic acid 102121-60-8 AM580 is the stable retinobenzoic derivative that acts as an agonist of RARα.
CSN24873 All-trans-retinal 116-31-4 All trans-Retinal, a component of the retinoid cycle, is converted to retinoic acid in vivo by the action of retinal dehydrogenase. Retinoic acid is a ligand for both RAR and RXR. All trans-retinal ias a potent photosensitizer.
CSN18484 AGN 205728 859498-05-8 AGN 205728 is a potent and selective RARγ antagonist with Ki/IC95 values of 3 nM/ 0.6 nM showing no inhibiton on RARα and RARβ.
CSN17042 AGN 196996 958295-17-5 AGN 196996 is a potent and selective RARα antagonist with Ki value of 2 nM showing little binding affinity for RARβ (Ki=1087 nM) and RARγ (Ki=8523 nM).
CSN13752 AGN-195183 367273-07-2 AGN 195183 is a potent and selective agonist of RARα (Kd=3 nM) with improved binding selectivity relative to AGN 193836, displaying no activity on RARβ/γ.
CSN18141 AGN 194310 229961-45-9 AGN 194310 is a potent and selective pan-RARs agonist with Kd values of 3/2/5 nM for RARα/β/γ respectively.
CSN21338 AGN 194078 321995-62-4 AGN 194078 is a selective RARα agonist with a Kd and EC50 of 3 and 112 nM, respectively.
CSN22670 AGN 193109 171746-21-7 AGN 193109 is a high affinity pan-retinoic acid receptor (RAR) antagonist with Kds of 2, 2 and 3 nM at RARα, RARβ and RARγ, respectively.
CSN18560 Adapalene sodium salt 911110-93-5 Adapalene sodium is a synthetic retinoid which is a Retinoic acid receptor agonist (RAR).
CSN18590 Acitretin sodium 925701-88-8 Acitretin sodium is a second-generation, systemic retinoid and an agonist for retinoic acid receptors that has been used in the treatment of psoriasis.
CSN12772 Acitretin 55079-83-9 Acitretin is an analog of retinoid that can activate α-secretase ADAM10 gene expression. It has been used in the treatment of severe psoriasis.
CSN19699 AC-55649 59662-49-6 AC55649 is an agonist of the retinoic acid receptor β (RAR-β).
CSN12719 Tarenflurbil 51543-40-9 (R)-Flurbiprofen is the R-enantiomer of the racemate NSAID flurbiprofen, inhibiting the binding of [3H]9-cis-RA to RXRαLBD with IC50 of 75 μM.
CSN93618 (2E,4E,6Z,8E)-3,7-Dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)nona-2,4,6,8-tetraenoic acid 5300-03-8
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