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RIP Kinase
| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| CSN17743 | WEHI-345 | 1354825-58-3 | WEHI-345 is a potent and selective inhibitor of RIPK2, with IC50 of 0.13 μM. |
| CSN26751 | RIPK3-IN-1 | 2361139-70-8 | RIPK3-IN-1 is a RIPK3 type II DFG-out inhibitor with an IC50 of 9.1 nM. RIPK3-IN-1 inhibits RIPK1 and RIPK2 with IC50s of 5.5 and >10 μM. RIPK3-IN-1 is also a c-Met kinase inhibitor with an IC50 of 1.1 μM[1]. |
| CSN26118 | RIPA-56 | 1956370-21-0 | RIPA-56 is a RIP1 inhibitor with EC50 value of 28nM. It efficiently reduced TNFα-induced mortality and multi-organ damage. |
| CSN19068 | RIP2 kinase inhibitor 2 | 1581270-11-2 | RIP2 kinase inhibitor 2 is a receptor interacting protein-2 (RIP2) kinase inhibitor. |
| CSN19069 | GSK2983559 active metabolite | 1423186-80-4 | RIP2 kinase inhibitor 1 is a receptor interacting protein-2 (RIP2) kinase inhibitor. |
| CSN28473 | PROTAC RIPK degrader-6 | 2089205-64-9 | PROTAC RIPK degrader-6 (example 1) is a PROTAC targeting RIP Kinase degradation wherein the RIP2 kinase inhibitor is linked via a linker to a cereblon binder. |
| CSN28460 | PROTAC RIPK degrader-2 | 1801547-16-9 | PROTAC RIPK degrader-2 is a nonpeptidic PROTAC which potently targets serine-threonine kinase RIPK2 and has highly selective for RIPK2 degradation. |
| CSN11637 | Necrostatin-1 | 4311-88-0 | Necrostatin-1 is an inhibitor of RIP1 and can decrease TNF-α-induced necroptosis with EC50 of 490 nM. |
| CSN33247 | Necrostatin-34 | 375835-43-1 | Nec-34 can synergize with Nec-1s to inhibit RIPK1 in vitro and in vivo. |
| CSN23683 | HS-1371 | 2158197-70-5 | HS1371 is an ATP-competitive and novel kinase inhibitor of RIP3-mediated necroptosis which can directly bind to RIP3. |
| CSN17724 | GSK583 | 1346547-00-9 | GSK583 is a selective inhibitor of RIP2 Kinase and IC50 value is 5 nM. |
| CSN25567 | GSK3145095 | 1622849-43-7 | GSK3145095 is a potent and orally active RIPK1 inhibitor with IC50 of 5 nM and potential antineoplastic and immunomodulatory activities. |
| CSN25270 | GSK2983559 free acid | 1579965-12-0 | GSK2983559 free acid is a small-molecule inhibitor of RIP2 kinase. GSK2983559 free acid potently binds to RIP2 kinase with good kinase specificity and has excellent activity in blocking many proinflammatory cytokine responses in vivo . |
| CSN19682 | GSK2982772 | 1622848-92-3 | GSK2982772 is an inhibitor of receptor interacting protein 1 (RIP1) with IC50 of 16 nM and it is used for the treatment of inflammatory diseases. |
| CSN23895 | GSK547 | 2226735-55-1 | GSK'547 is a highly selective and potent RIP1 inhibitor with improved oral bioavailability. |
| CSN33246 | nec-34i | 2212541-00-7 | |
| CSN43646 | GSK2593074A | 1337531-06-2 |
