Rituximab is a genetically engineered chimeric murine/human monoclonal antibody that targets CD20, a B-cell-specific surface antigen. It was the first monoclonal anti-CD20 antibody to be approved for
medical use in human diseases. It was initially licensed for non-Hodgkin‟s lymphoma and then made available for chronic lymphocytic leukemia, rheumatoid arthritis, granulomatosis with polyangiitis, and microscopic polyangiitis. RTX was also successfully used off-label to treat neuromyelitis optica spectrum disorders, MS, myasthenia gravis, autoimmune encephalitis, autoimmune neuropathies, and myopathies.
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Tian X, Chen C, Ma L, et al. Efficacy and safety of rituximab in relapsing-remitting multiple sclerosis: A systematic review and meta-analysis [published online ahead of print, 2020 Jul 10]. J Neuroimmunol. 2020;347:577317. doi:10.1016/j.jneuroim.2020.577317|https://pubmed.ncbi.nlm.nih.gov/32731048/